Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

Janne S Tolstrup, Jane L Hansen, Morten Grønbaek, Ulla Vogel, Anne Tjønneland, Albert Marni Joensen, Kim Overvad

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH). We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993-1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Public Health
Vol/bind38
Udgave nummer5
Sider (fra-til)489-494
Antal sider6
ISSN1403-4948
DOI
StatusUdgivet - 1. jul. 2010

Fingeraftryk

Alcohol Dehydrogenase
Acute Coronary Syndrome
Alcohol Drinking
Habits
Alcohols
Drinking
Cohort Studies
Diet
Health
Neoplasms

Citer dette

Tolstrup, Janne S ; Hansen, Jane L ; Grønbaek, Morten ; Vogel, Ulla ; Tjønneland, Anne ; Joensen, Albert Marni ; Overvad, Kim. / Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. I: Scandinavian Journal of Public Health. 2010 ; Bind 38, Nr. 5. s. 489-494.
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abstract = "Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH). We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993-1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.",
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Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. / Tolstrup, Janne S; Hansen, Jane L; Grønbaek, Morten; Vogel, Ulla; Tjønneland, Anne; Joensen, Albert Marni; Overvad, Kim.

I: Scandinavian Journal of Public Health, Bind 38, Nr. 5, 01.07.2010, s. 489-494.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome

AU - Tolstrup, Janne S

AU - Hansen, Jane L

AU - Grønbaek, Morten

AU - Vogel, Ulla

AU - Tjønneland, Anne

AU - Joensen, Albert Marni

AU - Overvad, Kim

N1 - First published on May 21, 2010

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH). We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993-1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

AB - Aims: The risk of myocardial infarction is lower among light-to-moderate drinkers compared with abstainers. Results from some previous studies, but not all, suggest that this association is modified by variations in genes coding for alcohol dehydrogenase (ADH). We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking. Methods: we conducted a nested case-cohort study within the Danish Diet, Cancer and Health study, including 1,645 men (770 incident cases of acute coronary syndrome from 1993-1997 through 2004 and 875 randomly selected controls). Results: Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes. Conclusions: The importance of functional variation in alcohol dehydrogenase for the association between alcohol drinking habits and the risk of developing acute coronary syndrome, if any, is very limited.

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KW - Male

KW - Middle Aged

KW - Questionnaires

KW - Risk Factors

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