Alcohol and cirrhosis: dose--response or threshold effect?

Mads Kamper-Jørgensen, Morten Grønbaek, Janne Tolstrup, Ulrik Becker

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2004-Jul
OriginalsprogEngelsk
TidsskriftJournal of Hepatology
Vol/bind41
Udgave nummer1
Sider (fra-til)25-30
Antal sider5
ISSN0168-8278
DOI
StatusUdgivet - 1. jul. 2004

Fingeraftryk

Alcoholic Liver Cirrhosis
Alcohols
Proportional Hazards Models
Population
Drinking
Cohort Studies
Prospective Studies

Citer dette

@article{e1261090e0ba11dd9909000ea68e967b,
title = "Alcohol and cirrhosis: dose--response or threshold effect?",
abstract = "BACKGROUND/AIMS: General population studies have shown a strong association between alcohol intake and death from alcoholic cirrhosis, but whether this is a dose-response or a threshold effect remains unknown, and the relation among alcohol misusers has not been studied. METHODS: A cohort of 6152 alcohol misusing men and women aged 15-83 were interviewed about drinking pattern and social issues and followed for 84,257 person-years. Outcome was alcoholic cirrhosis mortality. Data was analyzed by means of Cox-regression models. RESULTS: In this large prospective cohort study of alcohol misusers there was a 27 fold increased mortality from alcoholic cirrhosis in men and a 35 fold increased mortality from alcoholic cirrhosis in women compared to the Danish population. Number of drinks per day was not significantly associated with death from alcoholic cirrhosis, since there was no additional risk of death from alcoholic cirrhosis when exceeding an average daily number of five drinks (>60 g/alcohol) in neither men nor women. CONCLUSIONS: The results indicate that alcohol has a threshold effect rather than a dose-response effect on mortality from alcoholic cirrhosis in alcohol misusers.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Alcohol Drinking, Female, Follow-Up Studies, Humans, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Prospective Studies, Risk Factors, Severity of Illness Index",
author = "Mads Kamper-J{\o}rgensen and Morten Gr{\o}nbaek and Janne Tolstrup and Ulrik Becker",
year = "2004",
month = "7",
day = "1",
doi = "10.1016/j.jhep.2004.03.002",
language = "English",
volume = "41",
pages = "25--30",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "1",

}

Alcohol and cirrhosis: dose--response or threshold effect? / Kamper-Jørgensen, Mads; Grønbaek, Morten; Tolstrup, Janne; Becker, Ulrik.

I: Journal of Hepatology, Bind 41, Nr. 1, 01.07.2004, s. 25-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Alcohol and cirrhosis: dose--response or threshold effect?

AU - Kamper-Jørgensen, Mads

AU - Grønbaek, Morten

AU - Tolstrup, Janne

AU - Becker, Ulrik

PY - 2004/7/1

Y1 - 2004/7/1

N2 - BACKGROUND/AIMS: General population studies have shown a strong association between alcohol intake and death from alcoholic cirrhosis, but whether this is a dose-response or a threshold effect remains unknown, and the relation among alcohol misusers has not been studied. METHODS: A cohort of 6152 alcohol misusing men and women aged 15-83 were interviewed about drinking pattern and social issues and followed for 84,257 person-years. Outcome was alcoholic cirrhosis mortality. Data was analyzed by means of Cox-regression models. RESULTS: In this large prospective cohort study of alcohol misusers there was a 27 fold increased mortality from alcoholic cirrhosis in men and a 35 fold increased mortality from alcoholic cirrhosis in women compared to the Danish population. Number of drinks per day was not significantly associated with death from alcoholic cirrhosis, since there was no additional risk of death from alcoholic cirrhosis when exceeding an average daily number of five drinks (>60 g/alcohol) in neither men nor women. CONCLUSIONS: The results indicate that alcohol has a threshold effect rather than a dose-response effect on mortality from alcoholic cirrhosis in alcohol misusers.

AB - BACKGROUND/AIMS: General population studies have shown a strong association between alcohol intake and death from alcoholic cirrhosis, but whether this is a dose-response or a threshold effect remains unknown, and the relation among alcohol misusers has not been studied. METHODS: A cohort of 6152 alcohol misusing men and women aged 15-83 were interviewed about drinking pattern and social issues and followed for 84,257 person-years. Outcome was alcoholic cirrhosis mortality. Data was analyzed by means of Cox-regression models. RESULTS: In this large prospective cohort study of alcohol misusers there was a 27 fold increased mortality from alcoholic cirrhosis in men and a 35 fold increased mortality from alcoholic cirrhosis in women compared to the Danish population. Number of drinks per day was not significantly associated with death from alcoholic cirrhosis, since there was no additional risk of death from alcoholic cirrhosis when exceeding an average daily number of five drinks (>60 g/alcohol) in neither men nor women. CONCLUSIONS: The results indicate that alcohol has a threshold effect rather than a dose-response effect on mortality from alcoholic cirrhosis in alcohol misusers.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alcohol Drinking

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Liver Cirrhosis, Alcoholic

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Risk Factors

KW - Severity of Illness Index

U2 - 10.1016/j.jhep.2004.03.002

DO - 10.1016/j.jhep.2004.03.002

M3 - Journal article

VL - 41

SP - 25

EP - 30

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 1

ER -