Albumin-corrected Zn and available free Zn-binding capacity as indicators of Zn status: potential for clinical implementation

Louise H. Jørgensen, Mia D. Sørensen, Mette M. Lauridsen, L. M. Rasmussen, Rose M. Alfiler, Vilde N. Iversen, Ove B. Schaffalitzky de Muckadell*

*Kontaktforfatter for dette arbejde

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Abstrakt

We have established and describe two measurement procedures to diagnose possible zinc (Zn) deficiency; albumin-corrected Zn concentration and available free Zn-binding capacity. Reference intervals for both biomarkers were established in healthy adults from the Danish population. The clinical usefulness of the measurement procedures was investigated in patients with cirrhosis and in patients given parenteral nutrition due to short bowel syndrome. The results of both methods indicate that there is a risk of overdiagnosing Zn deficiency based on low plasma Zn concentrations. Needless Zn supplementation may thus be avoided by using the albumin-corrected Zn concentration or available free Zn-binding capacity.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical and Laboratory Investigation
Vol/bind82
Udgave nummer4
Sider (fra-til)261-266
ISSN0036-5513
DOI
StatusUdgivet - 2022

Bibliografisk note

Publisher Copyright:
© 2022 Medisinsk Fysiologisk Forenings Forlag (MFFF).

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