Akut eksacerbation af fibrotiske interstitielle lungesygdomme: Acute exacerbation of fibrotic interstitial lung diseases

Nils Hoyer, Elizabeth Bendstrup, Jesper Rømhild Davidsen, Thomas Kromann Lund, Saher Burhan Shaker

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) and other fibrotic interstitial lung diseases (AE-ILD) is defined by significant acute respiratory worsening and new widespread alveolar damage. This review summarises the current knowledge of diagnosis and treatment of these events. The diagnosis of AE-IPF and AE-ILD is based on typical HRCT findings of new and bilateral ground glass opacification and/or consolidation, and exclusion of fluid overload or cardiac failure. Treatment relies, despite low quality of evidence, on glucocorticoid in addition to supportive and palliative treatment. Despite treatment, the prognosis is poor, with a median survival of 2-4 months.

TidsskriftUgeskrift for Laeger
StatusE-pub ahead of print - 14. aug. 2023


  • Glucocorticoids/therapeutic use
  • Heart Failure
  • Humans
  • Idiopathic Pulmonary Fibrosis/diagnostic imaging
  • Lung Diseases, Interstitial/diagnostic imaging
  • Palliative Care