Aging in Escherichia coli: stochasticity, individual heterogeneity and mortality plateaus

Publikation: Konferencebidrag uden forlag/tidsskriftPosterFormidling

Resumé

Senescence is the decline of function with age that results from damage accumulation over the lifespan. It evolves because selective forces decrease with age. Despite substantial interest in senescence, evidence for even such general aging mechanisms is ambiguous. Many mechanisms and factors are suggested to be involved in aging and senescence, but no mechanism or factor has been unambiguously identified.
Here, we report on surprising patterns of aging and senescence from isogenic individual Escherichia coli bacteria grown under identical environmental conditions in a microfluidic device. Such simple organisms are expected to show senescence because of asymmetric division of accumulated damage among mother and daughter cells, accumulation of late acting deleterious mutations, or antagonistic pleiotropic effects.
OriginalsprogEngelsk
Publikationsdatonov. 2014
StatusUdgivet - nov. 2014

Fingeraftryk

Lab-On-A-Chip Devices
Mutation

Citer dette

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title = "Aging in Escherichia coli: stochasticity, individual heterogeneity and mortality plateaus",
abstract = "Senescence is the decline of function with age that results from damage accumulation over the lifespan. It evolves because selective forces decrease with age. Despite substantial interest in senescence, evidence for even such general aging mechanisms is ambiguous. Many mechanisms and factors are suggested to be involved in aging and senescence, but no mechanism or factor has been unambiguously identified. Here, we report on surprising patterns of aging and senescence from isogenic individual Escherichia coli bacteria grown under identical environmental conditions in a microfluidic device. Such simple organisms are expected to show senescence because of asymmetric division of accumulated damage among mother and daughter cells, accumulation of late acting deleterious mutations, or antagonistic pleiotropic effects.",
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Aging in Escherichia coli: stochasticity, individual heterogeneity and mortality plateaus. / Steiner, Uli.

2014.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterFormidling

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AU - Steiner, Uli

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N2 - Senescence is the decline of function with age that results from damage accumulation over the lifespan. It evolves because selective forces decrease with age. Despite substantial interest in senescence, evidence for even such general aging mechanisms is ambiguous. Many mechanisms and factors are suggested to be involved in aging and senescence, but no mechanism or factor has been unambiguously identified. Here, we report on surprising patterns of aging and senescence from isogenic individual Escherichia coli bacteria grown under identical environmental conditions in a microfluidic device. Such simple organisms are expected to show senescence because of asymmetric division of accumulated damage among mother and daughter cells, accumulation of late acting deleterious mutations, or antagonistic pleiotropic effects.

AB - Senescence is the decline of function with age that results from damage accumulation over the lifespan. It evolves because selective forces decrease with age. Despite substantial interest in senescence, evidence for even such general aging mechanisms is ambiguous. Many mechanisms and factors are suggested to be involved in aging and senescence, but no mechanism or factor has been unambiguously identified. Here, we report on surprising patterns of aging and senescence from isogenic individual Escherichia coli bacteria grown under identical environmental conditions in a microfluidic device. Such simple organisms are expected to show senescence because of asymmetric division of accumulated damage among mother and daughter cells, accumulation of late acting deleterious mutations, or antagonistic pleiotropic effects.

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