Affinity of drugs for cytochrome P-450 determined by inhibition of p-nitrophenetole O-deethylation by rat liver microsomes

Medicin og biovidenskab

• 4-nitrophenetol 100%
• 4-nitrophenol 64%
• Liver Microsomes 49%
• Cytochrome P-450 Enzyme System 42%
• Proadifen 21%
• Cytochromes b5 20%
• Oxygen 20%
• Disulfiram 20%
• Pharmaceutical Preparations 17%
• Isoniazid 16%
• Phenytoin 16%
• Chloramphenicol 16%
• NADP 15%
• Carbon Monoxide 14%
• Drug Interactions 14%

Kemiske forbindelser

• Cytochrome 37%
• Disulfiram 33%
• Cytochrome B5 29%
• Phenytoin 29%
• Km 27%
• Chloramphenicol 26%
• Drug 22%
• Dioxygen 21%