Adverse reactions to food additives in children with atopic symptoms

G Fuglsang, G Madsen, S Halken, S Jørgensen, O Osterballe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

In a multicenter study conducted at four Danish hospital pediatric departments, the parents of 472 consecutive children were informed of this project to determine the incidence of intolerance of food additives among children referred to an allergy clinic with symptoms of asthma, atopic dermatitis, rhinitis, or urticaria. After a 2-week period on an additive-free diet, the children were challenged with the eliminated additives. The food additives investigated were coloring agents, preservatives, citric acid, and flavoring agents. Carbonated "lemonade" containing the dissolved additives was used for the open challenge. Two doses were used: a low dose and a 10-fold higher dose. Gelatin capsules were used for a double-blind challenge. The children were 4-15 years old, and they were attending an outpatient pediatric clinic for the first time. Of the 379 patients who entered the study, 44 were excluded and 335 were subjected to open challenge. A total of 23 children developed positive reactions after the open challenge. Sixteen of these patients accepted the double-blind challenge, and six showed a positive reaction to preservatives (atopic dermatitis, asthma, rhinitis), coloring agents (atopic dermatitis, asthma, urticaria, gastrointestinal symptoms), and citric acid (atopic dermatitis, gastrointestinal symptoms). The incidence of intolerance of food additives was 2% (6/335), as based on the double-blind challenge, and 7% (23/335), as based on the open challenge with lemonade. Children with atopic skin symptoms had a statistically increased risk of a positive reaction. This may have consequences for the future clinical investigation of children with atopic cutaneous symptoms.

OriginalsprogEngelsk
TidsskriftAllergy
Vol/bind49
Udgave nummer1
Sider (fra-til)31-7
Antal sider7
ISSN0105-4538
StatusUdgivet - jan. 1994

Fingeraftryk

Food Additives
Atopic Dermatitis
Urticaria
Coloring Agents
Flavoring Agents
Skin
Hospital Departments
Incidence
Gelatin
Ambulatory Care Facilities
Multicenter Studies
Hypersensitivity
Parents
Pediatrics
Diet

Citer dette

Fuglsang, G ; Madsen, G ; Halken, S ; Jørgensen, S ; Osterballe, O. / Adverse reactions to food additives in children with atopic symptoms. I: Allergy. 1994 ; Bind 49, Nr. 1. s. 31-7.
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Fuglsang, G, Madsen, G, Halken, S, Jørgensen, S & Osterballe, O 1994, 'Adverse reactions to food additives in children with atopic symptoms', Allergy, bind 49, nr. 1, s. 31-7.

Adverse reactions to food additives in children with atopic symptoms. / Fuglsang, G; Madsen, G; Halken, S; Jørgensen, S; Osterballe, O.

I: Allergy, Bind 49, Nr. 1, 01.1994, s. 31-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Adverse reactions to food additives in children with atopic symptoms

AU - Fuglsang, G

AU - Madsen, G

AU - Halken, S

AU - Jørgensen, S

AU - Osterballe, O

PY - 1994/1

Y1 - 1994/1

N2 - In a multicenter study conducted at four Danish hospital pediatric departments, the parents of 472 consecutive children were informed of this project to determine the incidence of intolerance of food additives among children referred to an allergy clinic with symptoms of asthma, atopic dermatitis, rhinitis, or urticaria. After a 2-week period on an additive-free diet, the children were challenged with the eliminated additives. The food additives investigated were coloring agents, preservatives, citric acid, and flavoring agents. Carbonated "lemonade" containing the dissolved additives was used for the open challenge. Two doses were used: a low dose and a 10-fold higher dose. Gelatin capsules were used for a double-blind challenge. The children were 4-15 years old, and they were attending an outpatient pediatric clinic for the first time. Of the 379 patients who entered the study, 44 were excluded and 335 were subjected to open challenge. A total of 23 children developed positive reactions after the open challenge. Sixteen of these patients accepted the double-blind challenge, and six showed a positive reaction to preservatives (atopic dermatitis, asthma, rhinitis), coloring agents (atopic dermatitis, asthma, urticaria, gastrointestinal symptoms), and citric acid (atopic dermatitis, gastrointestinal symptoms). The incidence of intolerance of food additives was 2% (6/335), as based on the double-blind challenge, and 7% (23/335), as based on the open challenge with lemonade. Children with atopic skin symptoms had a statistically increased risk of a positive reaction. This may have consequences for the future clinical investigation of children with atopic cutaneous symptoms.

AB - In a multicenter study conducted at four Danish hospital pediatric departments, the parents of 472 consecutive children were informed of this project to determine the incidence of intolerance of food additives among children referred to an allergy clinic with symptoms of asthma, atopic dermatitis, rhinitis, or urticaria. After a 2-week period on an additive-free diet, the children were challenged with the eliminated additives. The food additives investigated were coloring agents, preservatives, citric acid, and flavoring agents. Carbonated "lemonade" containing the dissolved additives was used for the open challenge. Two doses were used: a low dose and a 10-fold higher dose. Gelatin capsules were used for a double-blind challenge. The children were 4-15 years old, and they were attending an outpatient pediatric clinic for the first time. Of the 379 patients who entered the study, 44 were excluded and 335 were subjected to open challenge. A total of 23 children developed positive reactions after the open challenge. Sixteen of these patients accepted the double-blind challenge, and six showed a positive reaction to preservatives (atopic dermatitis, asthma, rhinitis), coloring agents (atopic dermatitis, asthma, urticaria, gastrointestinal symptoms), and citric acid (atopic dermatitis, gastrointestinal symptoms). The incidence of intolerance of food additives was 2% (6/335), as based on the double-blind challenge, and 7% (23/335), as based on the open challenge with lemonade. Children with atopic skin symptoms had a statistically increased risk of a positive reaction. This may have consequences for the future clinical investigation of children with atopic cutaneous symptoms.

KW - Adolescent

KW - Asthma

KW - Child

KW - Child, Preschool

KW - Denmark

KW - Dermatitis, Atopic

KW - Double-Blind Method

KW - Female

KW - Food Additives

KW - Food Hypersensitivity

KW - Humans

KW - Incidence

KW - Male

KW - Rhinitis

KW - Urticaria

M3 - Journal article

C2 - 8198237

VL - 49

SP - 31

EP - 37

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 1

ER -