Advanced Glycation End Product (AGE) Accumulation in the Skin is Associated with Depression: The Maastricht Study

Fleur E P van Dooren, Frans Pouwer, Casper G Schalkwijk, Simone J S Sep, Coen D A Stehouwer, Ronald M A Henry, Pieter C Dagnelie, Nicolaas C Schaper, Carla J H van der Kallen, Annemarie Koster, Johan Denollet, Frans R J Verhey, Miranda T Schram

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Abstrakt

BACKGROUND: Depression is a highly prevalent disease with a high morbidity and mortality risk. Its pathophysiology is not entirely clear. However, type 2 diabetes is an important risk factor for depression. One mechanism that may explain this association may include the formation of advanced glycation end products (AGEs). We therefore investigated the association of AGEs with depressive symptoms and depressive disorder. In addition, we examined whether the potential association was present for somatic and/or cognitive symptoms of depression.

METHODS: Cross-sectional data were used from the Maastricht Study (N = 862, mean age 59.8 ± 8.5 years, 55% men). AGE accumulation was measured with skin autofluorescence (SAF) by use of the AGE Reader. Plasma levels of protein-bound pentosidine were measured with high-performance liquid chromatography and fluorescence detection. Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) were measured with ultraperformance liquid chromatography and tandem mass spectrometry. Depressive symptoms and depressive disorder were assessed by the nine-item Patient Health Questionnaire and the Mini-International Neuropsychiatric Interview.

RESULTS: Higher SAF was associated with depressive symptoms (β = 0.42, 95% CI 0.12-0.73, P = .007) and depressive disorder (OR = 1.42, 95% CI 1.04-1.95, P = .028) after adjustment for age, sex, type 2 diabetes, smoking, BMI, and kidney function. Plasma pentosidine, CML, and CEL were not independently associated with depressive symptoms and depressive disorder.

CONCLUSIONS: This study shows that AGE accumulation in the skin is independently associated with higher levels of depressive symptoms and depressive disorder. This association is present for both somatic and cognitive symptoms of depression. This might suggest that AGEs are involved in the development of depression.

OriginalsprogEngelsk
TidsskriftDepression and Anxiety
Vol/bind34
Udgave nummer1
Sider (fra-til)59-67
Antal sider9
ISSN1091-4269
DOI
StatusUdgivet - jan. 2017
Udgivet eksterntJa

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Volume 34, FOCUS ON MECHANISMS

Citationsformater

van Dooren, F. E. P., Pouwer, F., Schalkwijk, C. G., Sep, S. J. S., Stehouwer, C. D. A., Henry, R. M. A., Dagnelie, P. C., Schaper, N. C., van der Kallen, C. J. H., Koster, A., Denollet, J., Verhey, F. R. J., & Schram, M. T. (2017). Advanced Glycation End Product (AGE) Accumulation in the Skin is Associated with Depression: The Maastricht Study. Depression and Anxiety, 34(1), 59-67. https://doi.org/10.1002/da.22527