Adolescent idiopathic scoliosis in twins: a population-based survey

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
Udgivelsesdato: 2007-Apr-15
OriginalsprogEngelsk
TidsskriftSpine
Vol/bind32
Udgave nummer8
Sider (fra-til)927-30
Antal sider3
ISSN0362-2436
DOI
StatusUdgivet - 15. apr. 2007

Fingeraftryk

Scoliosis
Population
Dizygotic Twins
Surveys and Questionnaires
Monozygotic Twins
Registries

Citer dette

@article{07666c40dbc711dc860c000ea68e967b,
title = "Adolescent idiopathic scoliosis in twins: a population-based survey",
abstract = "STUDY DESIGN: A questionnaire-based identification of adolescent idiopathic scoliosis (AIS) patients in a twin cohort. OBJECTIVE: The purpose of this study was to establish a scoliosis twin cohort to provide data on the heritability of AIS. SUMMARY OF BACKGROUND DATA: The etiology of AIS is still unclear, and the true mode of inheritance has yet to be established. Concordance rates in monozygotic twins have been reported to be between 0.73 and 0.92, and in dizygotic twins between 0.36 and 0.63. Studies on concordance in twin pairs provide a basis for analyzing the influence of genetic versus environmental factors. METHODS: All 46,418 twins registered in the Danish Twin Registry born from 1931 to 1982 were sent a questionnaire, which included questions about scoliosis. A total of 34,944 (75.3{\%}) representing 23,204 pairs returned the questionnaire. RESULTS: A subgroup of 220 subjects considered to have AIS was identified, thus giving a prevalence of 1.05{\%}. The concordant twin pairs were all monozygotic. Pairwise, the concordance rate was 0.13 for monozygotic and zero for dizygotic twin pairs; proband-wise concordance was 0.25 for monozygotic and zero for dizygotic pairs. The concordance of monozygotic and dizygotic pairs was significantly different (P < 0.05). CONCLUSION: We have found evidence for a genetic etiology in AIS, but the risk of developing scoliosis in 1 twin whose other twin has scoliosis is smaller than believed up until now.",
keywords = "Adolescent, Adult, Aged, Cohort Studies, Data Collection, Denmark, Environment, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Models, Statistical, Prevalence, Questionnaires, Registries, Risk Factors, Scoliosis, Twins, Dizygotic, Twins, Monozygotic",
author = "Andersen, {Mikkel O} and Karsten Thomsen and Kyvik, {Kirsten O}",
year = "2007",
month = "4",
day = "15",
doi = "10.1097/01.brs.0000259865.08984.00",
language = "English",
volume = "32",
pages = "927--30",
journal = "Spine",
issn = "0362-2436",
publisher = "Lippincott Williams & Wilkins",
number = "8",

}

Adolescent idiopathic scoliosis in twins: a population-based survey. / Andersen, Mikkel O; Thomsen, Karsten; Kyvik, Kirsten O.

I: Spine, Bind 32, Nr. 8, 15.04.2007, s. 927-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Adolescent idiopathic scoliosis in twins: a population-based survey

AU - Andersen, Mikkel O

AU - Thomsen, Karsten

AU - Kyvik, Kirsten O

PY - 2007/4/15

Y1 - 2007/4/15

N2 - STUDY DESIGN: A questionnaire-based identification of adolescent idiopathic scoliosis (AIS) patients in a twin cohort. OBJECTIVE: The purpose of this study was to establish a scoliosis twin cohort to provide data on the heritability of AIS. SUMMARY OF BACKGROUND DATA: The etiology of AIS is still unclear, and the true mode of inheritance has yet to be established. Concordance rates in monozygotic twins have been reported to be between 0.73 and 0.92, and in dizygotic twins between 0.36 and 0.63. Studies on concordance in twin pairs provide a basis for analyzing the influence of genetic versus environmental factors. METHODS: All 46,418 twins registered in the Danish Twin Registry born from 1931 to 1982 were sent a questionnaire, which included questions about scoliosis. A total of 34,944 (75.3%) representing 23,204 pairs returned the questionnaire. RESULTS: A subgroup of 220 subjects considered to have AIS was identified, thus giving a prevalence of 1.05%. The concordant twin pairs were all monozygotic. Pairwise, the concordance rate was 0.13 for monozygotic and zero for dizygotic twin pairs; proband-wise concordance was 0.25 for monozygotic and zero for dizygotic pairs. The concordance of monozygotic and dizygotic pairs was significantly different (P < 0.05). CONCLUSION: We have found evidence for a genetic etiology in AIS, but the risk of developing scoliosis in 1 twin whose other twin has scoliosis is smaller than believed up until now.

AB - STUDY DESIGN: A questionnaire-based identification of adolescent idiopathic scoliosis (AIS) patients in a twin cohort. OBJECTIVE: The purpose of this study was to establish a scoliosis twin cohort to provide data on the heritability of AIS. SUMMARY OF BACKGROUND DATA: The etiology of AIS is still unclear, and the true mode of inheritance has yet to be established. Concordance rates in monozygotic twins have been reported to be between 0.73 and 0.92, and in dizygotic twins between 0.36 and 0.63. Studies on concordance in twin pairs provide a basis for analyzing the influence of genetic versus environmental factors. METHODS: All 46,418 twins registered in the Danish Twin Registry born from 1931 to 1982 were sent a questionnaire, which included questions about scoliosis. A total of 34,944 (75.3%) representing 23,204 pairs returned the questionnaire. RESULTS: A subgroup of 220 subjects considered to have AIS was identified, thus giving a prevalence of 1.05%. The concordant twin pairs were all monozygotic. Pairwise, the concordance rate was 0.13 for monozygotic and zero for dizygotic twin pairs; proband-wise concordance was 0.25 for monozygotic and zero for dizygotic pairs. The concordance of monozygotic and dizygotic pairs was significantly different (P < 0.05). CONCLUSION: We have found evidence for a genetic etiology in AIS, but the risk of developing scoliosis in 1 twin whose other twin has scoliosis is smaller than believed up until now.

KW - Adolescent

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Data Collection

KW - Denmark

KW - Environment

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Middle Aged

KW - Models, Statistical

KW - Prevalence

KW - Questionnaires

KW - Registries

KW - Risk Factors

KW - Scoliosis

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1097/01.brs.0000259865.08984.00

DO - 10.1097/01.brs.0000259865.08984.00

M3 - Journal article

C2 - 17426641

VL - 32

SP - 927

EP - 930

JO - Spine

JF - Spine

SN - 0362-2436

IS - 8

ER -