Adipose tissue at single-cell resolution

Babukrishna Maniyadath, Qianbin Zhang, Rana K. Gupta*, Susanne Mandrup


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Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological conditions. The emergence of single-cell transcriptomics has rapidly transformed our understanding of the diverse array of cell types and cell states residing in adipose tissues and has provided insight into how transcriptional changes in individual cell types contribute to tissue plasticity. Here, we present a comprehensive overview of the cellular atlas of adipose tissues focusing on the biological insight gained from single-cell and single-nuclei transcriptomics of murine and human adipose tissues. We also offer our perspective on the exciting opportunities for mapping cellular transitions and crosstalk, which have been made possible by single-cell technologies.

TidsskriftCell Metabolism
Udgave nummer3
Sider (fra-til)386-413
StatusUdgivet - 7. mar. 2023

Bibliografisk note

Funding Information:
B.M. and S.M. are supported by grants from the Danish National Research Foundation (DNRF grant no. 141 to the Center for Functional Genomics and Tissue Plasticity [ATLAS]) and grants from the Novo Nordisk Foundation ( NNF18OC0033444 Challenge Grant to the Center for Adipocyte Signaling [ADIPOSIGN]). Furthermore, B.M. is supported by the EMBO post-doctoral fellowship ( ALTF 146-2021 ). Q.Z. and R.K.G. are supported by National Institutes of Health NIDDK awards R01 DK104789 , RC2 DK118620 , and R01 DK119163 to R.K.G. B.M. and S.M. would like to acknowledge Elvira Laila van Hauwaert as well as other members of Mandrup Group for the discussions and input.

Publisher Copyright:
© 2023 Elsevier Inc.


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