Adipose-Derived Stem Cells

New Treatment for Wound Healing?

Navid Mohamadpour Toyserkani, Marlene Louise Quaade , Søren Paludan Sheikh, Jens Ahm Sørensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Emerging evidence has shown that adipose tissue is the richest and most accessible source of mesenchymal stem cells. Many different therapies for chronic wounds exist with varying success rates. The capacity of adipose-derived stem cells (ASCs) to promote angiogenesis, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types makes them a potential ideal therapy for chronic wounds. The aim of this article was to review all preclinical trials using ASCs in problem wound models. A systematic search was performed and 12 studies were found where different chronic wound models across different animals were treated with ASCs. Different ASC sources and delivery methods were used in the described studies. Studies demonstrated improved wound healing with utilization of ASC, and this treatment modality has so far shown great potential. However, more preclinical studies and large-scale clinical trials are needed to show if the emerging therapy can satisfy expectations.

OriginalsprogEngelsk
TidsskriftAnnals of Plastic Surgery
Vol/bind75
Udgave nummer1
Sider (fra-til)117-123
ISSN0148-7043
DOI
StatusUdgivet - 2015

Fingeraftryk

Wounds and Injuries
Mesenchymal Stromal Cells
Adipose Tissue
Clinical Trials

Citer dette

Toyserkani, Navid Mohamadpour ; Quaade , Marlene Louise ; Sheikh, Søren Paludan ; Sørensen, Jens Ahm. / Adipose-Derived Stem Cells : New Treatment for Wound Healing?. I: Annals of Plastic Surgery. 2015 ; Bind 75, Nr. 1. s. 117-123.
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Adipose-Derived Stem Cells : New Treatment for Wound Healing? / Toyserkani, Navid Mohamadpour; Quaade , Marlene Louise; Sheikh, Søren Paludan; Sørensen, Jens Ahm.

I: Annals of Plastic Surgery, Bind 75, Nr. 1, 2015, s. 117-123.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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T1 - Adipose-Derived Stem Cells

T2 - New Treatment for Wound Healing?

AU - Toyserkani, Navid Mohamadpour

AU - Quaade , Marlene Louise

AU - Sheikh, Søren Paludan

AU - Sørensen, Jens Ahm

PY - 2015

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AB - Emerging evidence has shown that adipose tissue is the richest and most accessible source of mesenchymal stem cells. Many different therapies for chronic wounds exist with varying success rates. The capacity of adipose-derived stem cells (ASCs) to promote angiogenesis, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types makes them a potential ideal therapy for chronic wounds. The aim of this article was to review all preclinical trials using ASCs in problem wound models. A systematic search was performed and 12 studies were found where different chronic wound models across different animals were treated with ASCs. Different ASC sources and delivery methods were used in the described studies. Studies demonstrated improved wound healing with utilization of ASC, and this treatment modality has so far shown great potential. However, more preclinical studies and large-scale clinical trials are needed to show if the emerging therapy can satisfy expectations.

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