Addressing harms of screening – A review of outcomes in Cochrane reviews and suggestions for next steps

Minna Johansson*, Franciszek Borys, Hanna Peterson, Giulia Bilamour, Matteo Bruschettini, Karsten Juhl Jørgensen

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

23 Downloads (Pure)

Abstract

Objective: To investigate if Cochrane reviews that assess screening interventions address their major harms. Study design and setting: A systematic search for Cochrane reviews that assess screening interventions was performed. Two authors independently screened abstracts, assessed full-texts, and extracted data from included reviews. For each review, two authors judged whether each predefined harm was relevant. When the harm was judged as of questionable relevance, the review was excluded from the denominator in our calculations. Results: Forty-seven reviews were included. Overdiagnosis was addressed in 6 of 39 (15%), overtreatment in 7 of 43 (16%), and psychosocial consequences in 30 of 47 (64%) of reviews where this was judged relevant. When data on harms were included, they were generally not treated with the same methodological rigor as the benefits, with no assessment of the risk of bias or certainty of the evidence. About half of the Abstracts, Plain Language Summaries, and Summary of Findings tables did not include any harms. Conclusion: The underreporting of harms of screening in Cochrane reviews likely reflects primary research and is problematic. We call for broad collaboration to develop reporting guidelines and core outcome sets for studies of screening interventions.

OriginalsprogEngelsk
TidsskriftJournal of Clinical Epidemiology
Vol/bind129
Sider (fra-til)68-73
ISSN0895-4356
DOI
StatusUdgivet - jan. 2021
Udgivet eksterntJa

Bibliografisk note

Funding Information:
Role of funding source: This study was funded by Cochrane Sweden and the Nordic Cochrane Center. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; the decision to submit the manuscript for publication.

Fingeraftryk

Dyk ned i forskningsemnerne om 'Addressing harms of screening – A review of outcomes in Cochrane reviews and suggestions for next steps'. Sammen danner de et unikt fingeraftryk.

Citationsformater