Adaptive Response of T and B Cells in Atherosclerosis

Daniel F J Ketelhuth, Göran K Hansson

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in the artery wall. In the arterial intima, lipoprotein components that are generated through oxidative, lipolytic, and proteolytic activities lead to the formation of several danger-associated molecular patterns, which can activate innate immune cells as well as vascular cells. Moreover, self- and non-self-antigens, such as apolipoprotein B-100 and heat shock proteins, can contribute to vascular inflammation by triggering the response of T and B cells locally. This process can influence the initiation, progression, and stability of plaques. Substantial clinical and experimental data support that the modulation of adaptive immune system may be used for treating and preventing atherosclerosis. This may lead to the development of more selective and less harmful interventions, while keeping host defense mechanisms against infections and tumors intact. Approaches such as vaccination might become a realistic option for cardiovascular disease, especially if they can elicit regulatory T and B cells and the secretion of atheroprotective antibodies. Nevertheless, difficulties in translating certain experimental data into new clinical therapies remain a challenge. In this review, we discuss important studies on the function of T- and B-cell immunity in atherosclerosis and their manipulation to develop novel therapeutic strategies against cardiovascular disease.

OriginalsprogEngelsk
TidsskriftCirculation Research
Vol/bind118
Udgave nummer4
Sider (fra-til)668-78
Antal sider11
ISSN0009-7330
DOI
StatusUdgivet - 19. feb. 2016

Fingeraftryk

Regulatory B-Lymphocytes
Apolipoprotein B-100
Heat-Shock Proteins
LDL Lipoproteins
Lipoproteins
Immune System
Neoplasms
lipoprotein cholesterol

Citer dette

Ketelhuth, Daniel F J ; Hansson, Göran K. / Adaptive Response of T and B Cells in Atherosclerosis. I: Circulation Research. 2016 ; Bind 118, Nr. 4. s. 668-78.
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Adaptive Response of T and B Cells in Atherosclerosis. / Ketelhuth, Daniel F J; Hansson, Göran K.

I: Circulation Research, Bind 118, Nr. 4, 19.02.2016, s. 668-78.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Adaptive Response of T and B Cells in Atherosclerosis

AU - Ketelhuth, Daniel F J

AU - Hansson, Göran K

N1 - © 2016 American Heart Association, Inc.

PY - 2016/2/19

Y1 - 2016/2/19

N2 - Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in the artery wall. In the arterial intima, lipoprotein components that are generated through oxidative, lipolytic, and proteolytic activities lead to the formation of several danger-associated molecular patterns, which can activate innate immune cells as well as vascular cells. Moreover, self- and non-self-antigens, such as apolipoprotein B-100 and heat shock proteins, can contribute to vascular inflammation by triggering the response of T and B cells locally. This process can influence the initiation, progression, and stability of plaques. Substantial clinical and experimental data support that the modulation of adaptive immune system may be used for treating and preventing atherosclerosis. This may lead to the development of more selective and less harmful interventions, while keeping host defense mechanisms against infections and tumors intact. Approaches such as vaccination might become a realistic option for cardiovascular disease, especially if they can elicit regulatory T and B cells and the secretion of atheroprotective antibodies. Nevertheless, difficulties in translating certain experimental data into new clinical therapies remain a challenge. In this review, we discuss important studies on the function of T- and B-cell immunity in atherosclerosis and their manipulation to develop novel therapeutic strategies against cardiovascular disease.

AB - Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and accumulation of cholesterol-containing lipoproteins, particularly low-density lipoprotein, in the artery wall. In the arterial intima, lipoprotein components that are generated through oxidative, lipolytic, and proteolytic activities lead to the formation of several danger-associated molecular patterns, which can activate innate immune cells as well as vascular cells. Moreover, self- and non-self-antigens, such as apolipoprotein B-100 and heat shock proteins, can contribute to vascular inflammation by triggering the response of T and B cells locally. This process can influence the initiation, progression, and stability of plaques. Substantial clinical and experimental data support that the modulation of adaptive immune system may be used for treating and preventing atherosclerosis. This may lead to the development of more selective and less harmful interventions, while keeping host defense mechanisms against infections and tumors intact. Approaches such as vaccination might become a realistic option for cardiovascular disease, especially if they can elicit regulatory T and B cells and the secretion of atheroprotective antibodies. Nevertheless, difficulties in translating certain experimental data into new clinical therapies remain a challenge. In this review, we discuss important studies on the function of T- and B-cell immunity in atherosclerosis and their manipulation to develop novel therapeutic strategies against cardiovascular disease.

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KW - Animals

KW - Arteries/immunology

KW - Atherosclerosis/immunology

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KW - Humans

KW - Immunotherapy/methods

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KW - Plaque, Atherosclerotic

KW - T-Lymphocyte Subsets/immunology

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