Acyl-CoA binding protein is an essential protein in mammalian cell lines

Nils J. Færgeman, Jens Knudsen

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Abstrakt

In the present work, small interference RNA was used to knock-down acyl-CoA binding protein (ACBP) in HeLa, HepG2 and Chang cells. Transfection with ACBP-specific siRNA stopped growth, detached cells from the growth surface and blocked thymidine and acetate incorporation. The results show that depletion of ACBP in mammalian cells results in lethality, suggesting that ACBP is an essential protein.
OriginalsprogEngelsk
TidsskriftBiochemical Journal
Vol/bind368
Udgave nummerPt 3
Sider (fra-til)679-682
ISSN0264-6021
DOI
StatusUdgivet - 15. dec. 2002

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