Accuracy of automatic deformable structure propagation for high-field MRI guided prostate radiotherapy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation for MR linac (MRL) treatment, which is an important element to minimize re-planning time and reduce the risk of misrepresenting the target due to this time pressure.

METHODS: For 12 high-risk prostate cancer patients treated to the prostate and pelvic lymph nodes, target structures and organs at risk were delineated on both planning MR and CT scans and propagated using deformable registration to three T2 weighted MR scans acquired during the treatment course. Generated structures were evaluated against manual delineations on the repeated scans using intra-observer variation obtained on the planning MR as ground truth.

RESULTS: MR-to-MR propagated structures had significant less median surface distance and larger Dice similarity index compared to CT-MR propagation. The MR-MR propagation uncertainty was similar in magnitude to the intra-observer variation. Visual inspection of the deformed structures revealed that small anatomical differences between organs in source and destination image sets were generally well accounted for while large differences were not.

CONCLUSION: Both CT and MR based propagations require manual editing, but the current results show that MR-to-MR propagated structures require fewer corrections for high risk prostate cancer patients treated at a high-field MRL.

OriginalsprogEngelsk
TidsskriftSeminars in Radiation Oncology
Vol/bind15
Udgave nummer1
Sider (fra-til)32
ISSN1053-4296
DOI
StatusUdgivet - 7. feb. 2020

Fingeraftryk

Prostate
Observer Variation
Prostatic Neoplasms
Uncertainty
Lymph Nodes

Citer dette

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title = "Accuracy of automatic deformable structure propagation for high-field MRI guided prostate radiotherapy",
abstract = "BACKGROUND: In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation for MR linac (MRL) treatment, which is an important element to minimize re-planning time and reduce the risk of misrepresenting the target due to this time pressure.METHODS: For 12 high-risk prostate cancer patients treated to the prostate and pelvic lymph nodes, target structures and organs at risk were delineated on both planning MR and CT scans and propagated using deformable registration to three T2 weighted MR scans acquired during the treatment course. Generated structures were evaluated against manual delineations on the repeated scans using intra-observer variation obtained on the planning MR as ground truth.RESULTS: MR-to-MR propagated structures had significant less median surface distance and larger Dice similarity index compared to CT-MR propagation. The MR-MR propagation uncertainty was similar in magnitude to the intra-observer variation. Visual inspection of the deformed structures revealed that small anatomical differences between organs in source and destination image sets were generally well accounted for while large differences were not.CONCLUSION: Both CT and MR based propagations require manual editing, but the current results show that MR-to-MR propagated structures require fewer corrections for high risk prostate cancer patients treated at a high-field MRL.",
author = "Christiansen, {Rasmus L{\"u}beck} and Lars Dysager and Bertelsen, {Anders Smedegaard} and Olfred Hansen and Carsten Brink and Uffe Bernchou",
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Accuracy of automatic deformable structure propagation for high-field MRI guided prostate radiotherapy. / Christiansen, Rasmus Lübeck; Dysager, Lars; Bertelsen, Anders Smedegaard; Hansen, Olfred; Brink, Carsten; Bernchou, Uffe.

I: Seminars in Radiation Oncology, Bind 15, Nr. 1, 07.02.2020, s. 32.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Accuracy of automatic deformable structure propagation for high-field MRI guided prostate radiotherapy

AU - Christiansen, Rasmus Lübeck

AU - Dysager, Lars

AU - Bertelsen, Anders Smedegaard

AU - Hansen, Olfred

AU - Brink, Carsten

AU - Bernchou, Uffe

PY - 2020/2/7

Y1 - 2020/2/7

N2 - BACKGROUND: In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation for MR linac (MRL) treatment, which is an important element to minimize re-planning time and reduce the risk of misrepresenting the target due to this time pressure.METHODS: For 12 high-risk prostate cancer patients treated to the prostate and pelvic lymph nodes, target structures and organs at risk were delineated on both planning MR and CT scans and propagated using deformable registration to three T2 weighted MR scans acquired during the treatment course. Generated structures were evaluated against manual delineations on the repeated scans using intra-observer variation obtained on the planning MR as ground truth.RESULTS: MR-to-MR propagated structures had significant less median surface distance and larger Dice similarity index compared to CT-MR propagation. The MR-MR propagation uncertainty was similar in magnitude to the intra-observer variation. Visual inspection of the deformed structures revealed that small anatomical differences between organs in source and destination image sets were generally well accounted for while large differences were not.CONCLUSION: Both CT and MR based propagations require manual editing, but the current results show that MR-to-MR propagated structures require fewer corrections for high risk prostate cancer patients treated at a high-field MRL.

AB - BACKGROUND: In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation for MR linac (MRL) treatment, which is an important element to minimize re-planning time and reduce the risk of misrepresenting the target due to this time pressure.METHODS: For 12 high-risk prostate cancer patients treated to the prostate and pelvic lymph nodes, target structures and organs at risk were delineated on both planning MR and CT scans and propagated using deformable registration to three T2 weighted MR scans acquired during the treatment course. Generated structures were evaluated against manual delineations on the repeated scans using intra-observer variation obtained on the planning MR as ground truth.RESULTS: MR-to-MR propagated structures had significant less median surface distance and larger Dice similarity index compared to CT-MR propagation. The MR-MR propagation uncertainty was similar in magnitude to the intra-observer variation. Visual inspection of the deformed structures revealed that small anatomical differences between organs in source and destination image sets were generally well accounted for while large differences were not.CONCLUSION: Both CT and MR based propagations require manual editing, but the current results show that MR-to-MR propagated structures require fewer corrections for high risk prostate cancer patients treated at a high-field MRL.

U2 - 10.1186/s13014-020-1482-y

DO - 10.1186/s13014-020-1482-y

M3 - Journal article

C2 - 32033574

VL - 15

SP - 32

JO - Seminars in Radiation Oncology

JF - Seminars in Radiation Oncology

SN - 1053-4296

IS - 1

ER -