Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

Michiel Vellema*, Mariana Diales Rocha, Sabrina Bascones, Sándor Zsebők, Jes Dreier, Stefan Leitner, Annemie Van der Linden, Jonathan Brewer, Manfred Gahr

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Resumé

Complex motor skills take considerable time and practice to learn. Without continued practice the level of skill performance quickly degrades, posing a problem for the timely utilization of skilled motor behaviors. Here we quantified the recurring development of vocal motor skills and the accompanying changes in synaptic connectivity in the brain of a songbird, while manipulating skill performance by consecutively administrating and withdrawing testosterone. We demonstrate that a songbird with prior singing experience can significantly accelerate the re-acquisition of vocal performance. We further demonstrate that an increase in vocal performance is accompanied by a pronounced synaptic pruning in the forebrain vocal motor area HVC, a reduction that is not reversed when birds stop singing. These results provide evidence that lasting synaptic changes in the motor circuitry are associated with the savings of motor skills, enabling a rapid recovery of motor performance under environmental time constraints.

OriginalsprogEngelsk
Artikelnummere43194
TidsskrifteLife
Vol/bind8
Antal sider26
ISSN2050-084X
DOI
StatusUdgivet - 17. maj 2019

Fingeraftryk

Motor Skills
Music
Motor Cortex
Birds
Testosterone
Brain
Recovery

Citer dette

Vellema, M., Diales Rocha, M., Bascones, S., Zsebők, S., Dreier, J., Leitner, S., ... Gahr, M. (2019). Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry. eLife, 8, [e43194]. https://doi.org/10.7554/eLife.43194
Vellema, Michiel ; Diales Rocha, Mariana ; Bascones, Sabrina ; Zsebők, Sándor ; Dreier, Jes ; Leitner, Stefan ; Van der Linden, Annemie ; Brewer, Jonathan ; Gahr, Manfred. / Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry. I: eLife. 2019 ; Bind 8.
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abstract = "Complex motor skills take considerable time and practice to learn. Without continued practice the level of skill performance quickly degrades, posing a problem for the timely utilization of skilled motor behaviors. Here we quantified the recurring development of vocal motor skills and the accompanying changes in synaptic connectivity in the brain of a songbird, while manipulating skill performance by consecutively administrating and withdrawing testosterone. We demonstrate that a songbird with prior singing experience can significantly accelerate the re-acquisition of vocal performance. We further demonstrate that an increase in vocal performance is accompanied by a pronounced synaptic pruning in the forebrain vocal motor area HVC, a reduction that is not reversed when birds stop singing. These results provide evidence that lasting synaptic changes in the motor circuitry are associated with the savings of motor skills, enabling a rapid recovery of motor performance under environmental time constraints.",
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Vellema, M, Diales Rocha, M, Bascones, S, Zsebők, S, Dreier, J, Leitner, S, Van der Linden, A, Brewer, J & Gahr, M 2019, 'Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry', eLife, bind 8, e43194. https://doi.org/10.7554/eLife.43194

Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry. / Vellema, Michiel; Diales Rocha, Mariana; Bascones, Sabrina; Zsebők, Sándor; Dreier, Jes; Leitner, Stefan; Van der Linden, Annemie; Brewer, Jonathan; Gahr, Manfred.

I: eLife, Bind 8, e43194, 17.05.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

AU - Vellema, Michiel

AU - Diales Rocha, Mariana

AU - Bascones, Sabrina

AU - Zsebők, Sándor

AU - Dreier, Jes

AU - Leitner, Stefan

AU - Van der Linden, Annemie

AU - Brewer, Jonathan

AU - Gahr, Manfred

PY - 2019/5/17

Y1 - 2019/5/17

N2 - Complex motor skills take considerable time and practice to learn. Without continued practice the level of skill performance quickly degrades, posing a problem for the timely utilization of skilled motor behaviors. Here we quantified the recurring development of vocal motor skills and the accompanying changes in synaptic connectivity in the brain of a songbird, while manipulating skill performance by consecutively administrating and withdrawing testosterone. We demonstrate that a songbird with prior singing experience can significantly accelerate the re-acquisition of vocal performance. We further demonstrate that an increase in vocal performance is accompanied by a pronounced synaptic pruning in the forebrain vocal motor area HVC, a reduction that is not reversed when birds stop singing. These results provide evidence that lasting synaptic changes in the motor circuitry are associated with the savings of motor skills, enabling a rapid recovery of motor performance under environmental time constraints.

AB - Complex motor skills take considerable time and practice to learn. Without continued practice the level of skill performance quickly degrades, posing a problem for the timely utilization of skilled motor behaviors. Here we quantified the recurring development of vocal motor skills and the accompanying changes in synaptic connectivity in the brain of a songbird, while manipulating skill performance by consecutively administrating and withdrawing testosterone. We demonstrate that a songbird with prior singing experience can significantly accelerate the re-acquisition of vocal performance. We further demonstrate that an increase in vocal performance is accompanied by a pronounced synaptic pruning in the forebrain vocal motor area HVC, a reduction that is not reversed when birds stop singing. These results provide evidence that lasting synaptic changes in the motor circuitry are associated with the savings of motor skills, enabling a rapid recovery of motor performance under environmental time constraints.

KW - birdsong

KW - brain development

KW - canary

KW - dendritic spines

KW - neuroscience

KW - savings

KW - skill re-acquisition

U2 - 10.7554/eLife.43194

DO - 10.7554/eLife.43194

M3 - Journal article

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JO - eLife

JF - eLife

SN - 2050-084X

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Vellema M, Diales Rocha M, Bascones S, Zsebők S, Dreier J, Leitner S et al. Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry. eLife. 2019 maj 17;8. e43194. https://doi.org/10.7554/eLife.43194