ABO-incompatible kidney transplantation

Karoline Schousboe, Kjell Titlestad, Francois Baudier, Lars Ulrich Hansen, Claus Bistrup

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

INTRODUCTION: Kidney transplantation is the optimal treatment for many patients with end-stage renal disease (ESRD). Due to shortage of donor kidneys in Denmark, there is a need to expand the possibilities for donation. At the Odense University Hospital (OUH), we have introduced ABO-incompatible kidney transplantation. We used antigenspecific immunoadsorptions to remove blood group antibodies and anti-CD20 antibody (rituximab) to inhibit the antibody production. The aim of introducing the ABO-incompatible kidney transplantation at the OUH was to increase the rate of living donor kidney transplantation without increasing rejection or mortality rates. MATERIAL AND METHODS: Retrospective evaluation. Eleven patients received ABO-incompatible kidney transplantation. The patients were followed for 3-26 months. RESULTS: One patient had an antibody-mediated rejection, one patient suffered T-cell-mediated rejection, and one patient died of myocardial infarction with a functioning graft on the third post-operative day. Both rejections were treated effectively. Among the patients, the average serum creatinine level was 128 micromol/l. CONCLUSION: The rejection and mortality rates for ABO-incompatible kidney transplantation at the OUH are similar to the results from ABO-compatible kidney transplantations performed at the OUH and at other hospitals.
OriginalsprogEngelsk
TidsskriftDanish Medical Bulletin (Online)
Vol/bind57
Udgave nummer10
Sider (fra-til)A4197
ISSN1603-9629
StatusUdgivet - 1. okt. 2010

Fingeraftryk

Kidney Transplantation
Living Donors
Denmark
Creatinine
Kidney
Serum

Citer dette

Schousboe, K., Titlestad, K., Baudier, F., Hansen, L. U., & Bistrup, C. (2010). ABO-incompatible kidney transplantation. Danish Medical Bulletin (Online), 57(10), A4197.
Schousboe, Karoline ; Titlestad, Kjell ; Baudier, Francois ; Hansen, Lars Ulrich ; Bistrup, Claus. / ABO-incompatible kidney transplantation. I: Danish Medical Bulletin (Online). 2010 ; Bind 57, Nr. 10. s. A4197.
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Schousboe, K, Titlestad, K, Baudier, F, Hansen, LU & Bistrup, C 2010, 'ABO-incompatible kidney transplantation', Danish Medical Bulletin (Online), bind 57, nr. 10, s. A4197.

ABO-incompatible kidney transplantation. / Schousboe, Karoline; Titlestad, Kjell; Baudier, Francois; Hansen, Lars Ulrich; Bistrup, Claus.

I: Danish Medical Bulletin (Online), Bind 57, Nr. 10, 01.10.2010, s. A4197.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

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AU - Schousboe, Karoline

AU - Titlestad, Kjell

AU - Baudier, Francois

AU - Hansen, Lars Ulrich

AU - Bistrup, Claus

PY - 2010/10/1

Y1 - 2010/10/1

N2 - INTRODUCTION: Kidney transplantation is the optimal treatment for many patients with end-stage renal disease (ESRD). Due to shortage of donor kidneys in Denmark, there is a need to expand the possibilities for donation. At the Odense University Hospital (OUH), we have introduced ABO-incompatible kidney transplantation. We used antigenspecific immunoadsorptions to remove blood group antibodies and anti-CD20 antibody (rituximab) to inhibit the antibody production. The aim of introducing the ABO-incompatible kidney transplantation at the OUH was to increase the rate of living donor kidney transplantation without increasing rejection or mortality rates. MATERIAL AND METHODS: Retrospective evaluation. Eleven patients received ABO-incompatible kidney transplantation. The patients were followed for 3-26 months. RESULTS: One patient had an antibody-mediated rejection, one patient suffered T-cell-mediated rejection, and one patient died of myocardial infarction with a functioning graft on the third post-operative day. Both rejections were treated effectively. Among the patients, the average serum creatinine level was 128 micromol/l. CONCLUSION: The rejection and mortality rates for ABO-incompatible kidney transplantation at the OUH are similar to the results from ABO-compatible kidney transplantations performed at the OUH and at other hospitals.

AB - INTRODUCTION: Kidney transplantation is the optimal treatment for many patients with end-stage renal disease (ESRD). Due to shortage of donor kidneys in Denmark, there is a need to expand the possibilities for donation. At the Odense University Hospital (OUH), we have introduced ABO-incompatible kidney transplantation. We used antigenspecific immunoadsorptions to remove blood group antibodies and anti-CD20 antibody (rituximab) to inhibit the antibody production. The aim of introducing the ABO-incompatible kidney transplantation at the OUH was to increase the rate of living donor kidney transplantation without increasing rejection or mortality rates. MATERIAL AND METHODS: Retrospective evaluation. Eleven patients received ABO-incompatible kidney transplantation. The patients were followed for 3-26 months. RESULTS: One patient had an antibody-mediated rejection, one patient suffered T-cell-mediated rejection, and one patient died of myocardial infarction with a functioning graft on the third post-operative day. Both rejections were treated effectively. Among the patients, the average serum creatinine level was 128 micromol/l. CONCLUSION: The rejection and mortality rates for ABO-incompatible kidney transplantation at the OUH are similar to the results from ABO-compatible kidney transplantations performed at the OUH and at other hospitals.

M3 - Journal article

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JO - Danish Medical Journal

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SN - 1603-9629

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