Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes – Results from the EPICOM study

Zuzana Lohse, Birgitte Bytoft, Sine Knorr*, Tine D. Clausen, Rikke Beck Jensen, Henning Beck-Nielsen, Anne Pernille Hermann, Peter S. Oturai, Jan Frystyk, Peter Damm, Claus H. Gravholt, Kurt Højlund, Dorte M. Jensen

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Resumé

Aims/Hypothesis To investigate long-term consequences of diabetes during pregnancy, we determined adiponectin and leptin levels in adolescents born by women with type 1 diabetic (T1D) or non-diabetic mothers, and determined associations between adiponectin and leptin levels in adolescence and the magnitude of intrauterine hyperglycemia. Research design and methods We measured serum adiponectin and leptin and calculated leptin to adiponectin ratio (LAR) in 271 offspring of T1D women (index offspring) (13–20 years), and 297 matched control offspring. Anthropometry included total body fat (TBF) by dual-energy X-ray absorptiometry and an oral glucose tolerance test. Results Adiponectin levels were lower in index females (− 8.0% (95% CI; − 13.9, − 1.6)), but not in index males (0.4% (95% CI; − 7.3, 8.6)). Leptin levels were approximately 30% higher in index than control offspring, irrespective of gender. In males, this was seen despite similar TBF in index and control offspring. LAR was increased in index offspring (both males and females) compared with control offspring. There were no association between offspring adiponectin and maternal HbA1c levels in pregnancy. Leptin and LAR seemed to be associated with third trimester HbA1c levels in females in unadjusted, but not adjusted analyses. Conclusion Male and female offspring of women with T1D demonstrated increased serum leptin and LAR, whereas serum adiponectin was reduced in females only. These results suggest that abnormal regulation of adipokines is a consequence of being born to mothers with T1D. No direct association between maternal glycemic control and adiponectin and leptin levels or LAR in the adolescence was found. Clinical Trial Registration number: NCT01559181

OriginalsprogEngelsk
TidsskriftMetabolism
Vol/bind72
Sider (fra-til)47-56
ISSN0026-0495
DOI
StatusUdgivet - 2017

Fingeraftryk

Adiponectin
Leptin
Mothers
Adipose Tissue
Serum
Photon Absorptiometry
Third Pregnancy Trimester
Glucose Tolerance Test
Hyperglycemia
Research Design
Clinical Trials

Citer dette

Lohse, Zuzana ; Bytoft, Birgitte ; Knorr, Sine ; Clausen, Tine D. ; Beck Jensen, Rikke ; Beck-Nielsen, Henning ; Hermann, Anne Pernille ; Oturai, Peter S. ; Frystyk, Jan ; Damm, Peter ; Gravholt, Claus H. ; Højlund, Kurt ; Jensen, Dorte M. / Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes – Results from the EPICOM study. I: Metabolism. 2017 ; Bind 72. s. 47-56.
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abstract = "Aims/Hypothesis To investigate long-term consequences of diabetes during pregnancy, we determined adiponectin and leptin levels in adolescents born by women with type 1 diabetic (T1D) or non-diabetic mothers, and determined associations between adiponectin and leptin levels in adolescence and the magnitude of intrauterine hyperglycemia. Research design and methods We measured serum adiponectin and leptin and calculated leptin to adiponectin ratio (LAR) in 271 offspring of T1D women (index offspring) (13–20 years), and 297 matched control offspring. Anthropometry included total body fat (TBF) by dual-energy X-ray absorptiometry and an oral glucose tolerance test. Results Adiponectin levels were lower in index females (− 8.0{\%} (95{\%} CI; − 13.9, − 1.6)), but not in index males (0.4{\%} (95{\%} CI; − 7.3, 8.6)). Leptin levels were approximately 30{\%} higher in index than control offspring, irrespective of gender. In males, this was seen despite similar TBF in index and control offspring. LAR was increased in index offspring (both males and females) compared with control offspring. There were no association between offspring adiponectin and maternal HbA1c levels in pregnancy. Leptin and LAR seemed to be associated with third trimester HbA1c levels in females in unadjusted, but not adjusted analyses. Conclusion Male and female offspring of women with T1D demonstrated increased serum leptin and LAR, whereas serum adiponectin was reduced in females only. These results suggest that abnormal regulation of adipokines is a consequence of being born to mothers with T1D. No direct association between maternal glycemic control and adiponectin and leptin levels or LAR in the adolescence was found. Clinical Trial Registration number: NCT01559181",
keywords = "Adiponectin, Fetal programming, Leptin, Leptin to adiponectin ratio, Obesity",
author = "Zuzana Lohse and Birgitte Bytoft and Sine Knorr and Clausen, {Tine D.} and {Beck Jensen}, Rikke and Henning Beck-Nielsen and Hermann, {Anne Pernille} and Oturai, {Peter S.} and Jan Frystyk and Peter Damm and Gravholt, {Claus H.} and Kurt H{\o}jlund and Jensen, {Dorte M.}",
year = "2017",
doi = "10.1016/j.metabol.2017.04.002",
language = "English",
volume = "72",
pages = "47--56",
journal = "Metabolism",
issn = "0026-0495",
publisher = "Heinemann",

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Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes – Results from the EPICOM study. / Lohse, Zuzana; Bytoft, Birgitte; Knorr, Sine; Clausen, Tine D.; Beck Jensen, Rikke; Beck-Nielsen, Henning; Hermann, Anne Pernille; Oturai, Peter S.; Frystyk, Jan; Damm, Peter; Gravholt, Claus H.; Højlund, Kurt; Jensen, Dorte M.

I: Metabolism, Bind 72, 2017, s. 47-56.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes – Results from the EPICOM study

AU - Lohse, Zuzana

AU - Bytoft, Birgitte

AU - Knorr, Sine

AU - Clausen, Tine D.

AU - Beck Jensen, Rikke

AU - Beck-Nielsen, Henning

AU - Hermann, Anne Pernille

AU - Oturai, Peter S.

AU - Frystyk, Jan

AU - Damm, Peter

AU - Gravholt, Claus H.

AU - Højlund, Kurt

AU - Jensen, Dorte M.

PY - 2017

Y1 - 2017

N2 - Aims/Hypothesis To investigate long-term consequences of diabetes during pregnancy, we determined adiponectin and leptin levels in adolescents born by women with type 1 diabetic (T1D) or non-diabetic mothers, and determined associations between adiponectin and leptin levels in adolescence and the magnitude of intrauterine hyperglycemia. Research design and methods We measured serum adiponectin and leptin and calculated leptin to adiponectin ratio (LAR) in 271 offspring of T1D women (index offspring) (13–20 years), and 297 matched control offspring. Anthropometry included total body fat (TBF) by dual-energy X-ray absorptiometry and an oral glucose tolerance test. Results Adiponectin levels were lower in index females (− 8.0% (95% CI; − 13.9, − 1.6)), but not in index males (0.4% (95% CI; − 7.3, 8.6)). Leptin levels were approximately 30% higher in index than control offspring, irrespective of gender. In males, this was seen despite similar TBF in index and control offspring. LAR was increased in index offspring (both males and females) compared with control offspring. There were no association between offspring adiponectin and maternal HbA1c levels in pregnancy. Leptin and LAR seemed to be associated with third trimester HbA1c levels in females in unadjusted, but not adjusted analyses. Conclusion Male and female offspring of women with T1D demonstrated increased serum leptin and LAR, whereas serum adiponectin was reduced in females only. These results suggest that abnormal regulation of adipokines is a consequence of being born to mothers with T1D. No direct association between maternal glycemic control and adiponectin and leptin levels or LAR in the adolescence was found. Clinical Trial Registration number: NCT01559181

AB - Aims/Hypothesis To investigate long-term consequences of diabetes during pregnancy, we determined adiponectin and leptin levels in adolescents born by women with type 1 diabetic (T1D) or non-diabetic mothers, and determined associations between adiponectin and leptin levels in adolescence and the magnitude of intrauterine hyperglycemia. Research design and methods We measured serum adiponectin and leptin and calculated leptin to adiponectin ratio (LAR) in 271 offspring of T1D women (index offspring) (13–20 years), and 297 matched control offspring. Anthropometry included total body fat (TBF) by dual-energy X-ray absorptiometry and an oral glucose tolerance test. Results Adiponectin levels were lower in index females (− 8.0% (95% CI; − 13.9, − 1.6)), but not in index males (0.4% (95% CI; − 7.3, 8.6)). Leptin levels were approximately 30% higher in index than control offspring, irrespective of gender. In males, this was seen despite similar TBF in index and control offspring. LAR was increased in index offspring (both males and females) compared with control offspring. There were no association between offspring adiponectin and maternal HbA1c levels in pregnancy. Leptin and LAR seemed to be associated with third trimester HbA1c levels in females in unadjusted, but not adjusted analyses. Conclusion Male and female offspring of women with T1D demonstrated increased serum leptin and LAR, whereas serum adiponectin was reduced in females only. These results suggest that abnormal regulation of adipokines is a consequence of being born to mothers with T1D. No direct association between maternal glycemic control and adiponectin and leptin levels or LAR in the adolescence was found. Clinical Trial Registration number: NCT01559181

KW - Adiponectin

KW - Fetal programming

KW - Leptin

KW - Leptin to adiponectin ratio

KW - Obesity

U2 - 10.1016/j.metabol.2017.04.002

DO - 10.1016/j.metabol.2017.04.002

M3 - Journal article

C2 - 28641783

AN - SCOPUS:85018308891

VL - 72

SP - 47

EP - 56

JO - Metabolism

JF - Metabolism

SN - 0026-0495

ER -