A Wnt oscillator model for somitogenesis

Peter Bjødstrup Jensen, Lykke Pedersen, Sandeep Krishna, Mogens H Jensen, Peter Bjødstrup Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often spiky, where low concentration values of beta-catenin are interrupted by sharp peaks. Necessary for the oscillations is the saturated degradation of Axin2. Somite formation in chick and mouse embryos is controlled by a spatial Wnt gradient which we introduce in the model through a time-dependent decrease in Wnt3a ligand level. We find that the oscillations disappear as the ligand concentration decreases, in agreement with observations on embryos.

TidsskriftBiophysical Journal
Udgave nummer6
Sider (fra-til)943-50
Antal sider8
StatusUdgivet - 17. mar. 2010


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