A twin study of the trough plasma steady-state concentration of metformin

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Abstrakt

OBJECTIVE: The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations of metformin in monozygotic and dizygotic twin pairs.

METHODS: We included 16 twin pairs (eight monozygotic and eight dizygotic twin pairs) for this study after contacting 524 twin pairs. They were dosed with metformin to steady state (1 g twice daily) for 6 days and on day 7, the trough concentration of metformin was determined 12 h after the last dose.

RESULTS: There was no strong intrapair similarity in trough steady-state plasma concentrations of metformin in either dizygotic or monozygotic twin pairs.

CONCLUSION: The trough steady-state plasma concentration of metformin does not appear to be tightly genetically regulated. The interpretation of this finding is limited by the small sample size.
OriginalsprogEngelsk
TidsskriftPharmacogenetics and Genomics
Vol/bind25
Udgave nummer5
Sider (fra-til)259-262
ISSN1744-6872
DOI
StatusUdgivet - maj 2015

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