A systematic review of fatigue in patients with traumatic brain injury: The course, predictors and consequences

T. Mollayeva, T. Kendzerska, S. Mollayeva, C. M. Shapiro, A. Colantonio, J. D. Cassidy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Background: Fatigue is common after traumatic brain injury (TBI). Its risk factors, natural history and consequences are uncertain. Best-evidence synthesis was used to address the gaps. Methods: Five databases were searched for relevant peer-reviewed studies. Of the 33 articles appraised, 22 longitudinal studies were selected. Results were reported separately based on their timing of baseline assessment. Results: All studies document changes in fatigue frequency and severity with time, irrespective of setting or TBI severity. There is limited evidence for certain clinical and psychosocial variables as predictors of fatigue severity at follow-up. Early fatigue severity predicted persistent post-concussive symptoms and Glasgow outcome score at follow-up. Conclusions: Fatigue is present before and immediately following injury, and can persist long term. The variation in findings supports the idea of fatigue in TBI as a nonhomogeneous entity, with different factors influencing the course of new onset or chronic fatigue. To decrease the heterogeneity, we emphasize the need for agreement on a core set of relevant fatigue predictors, definitions and outcome criteria. (C) 2014 The Authors. Published by Elsevier Ltd.
TidsskriftNeuroscience and Behavioral Physiology
Sider (fra-til)684-716
StatusUdgivet - 2014

Bibliografisk note

ISI Document Delivery No.: AY3QY Times Cited: 0 Cited Reference Count: 99 Mollayeva, Tatyana Kendzerska, Tetyana Mollayeva, Shirin Shapiro, Colin M. Colantonio, Angela Cassidy, J. David Toronto Rehabilitation Institute Scholarship; Ontario Graduate Scholarship Our study had no external funding source. The first author was supported by 2012/2013 Toronto Rehabilitation Institute Scholarship, the Ontario Graduate Scholarship 2012/2013 and the 2013/2015 Frederick Banting and Charles Best Doctoral Research Award from the Canadian Institutes of Health Research. We recognize the support of the Toronto Rehabilitation Institute Foundation and a grant to the Ministry of Health and Long Term Care to the Toronto Rehabilitation Institute. Support was also provided through the Ontario Work Study Program. We gratefully acknowledge the involvement of Ms. Jessica Babineau, information specialist at the Toronto Rehabilitation Institute for her help with the literature search. The authors have no conflict of interest to declare pertaining to this review. 0 PERGAMON-ELSEVIER SCIENCE LTD OXFORD NEUROSCI BIOBEHAV R