A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients

Christine Paludan-Müller, Anita Lunde, Helle Johannessen

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingKonferenceabstrakt i proceedingsForskning

Resumé

Purpose

To provide an overview and evaluate the evidence of biologically based CAM-practices for cancer patients.

Methods

Pubmed, Social Science Citation Index, AMED and the Cochrane library were systematically searched for reviews on effects of biologically based CAM-practices, including herbal remedies, vitamins and other dietary supplements, for cancer or cancer related symptoms published 2000-2008. All studies were assessed according to the SIGN hierarchy of evidence.

Results

A total of 78 reviews/meta-analyses were identified. Of these, 32 were evaluated as high-quality, whereas 46 had low levels of evidence and were excluded from further evaluation.

Among the 32 high-quality reviews the most reviewed practices were soy/plant hormones (7), Chinese herbal medicine (7), antioxidants (5) and mistletoe (4). Fifteen of the 32 reviews included data on the efficacy of biologically-based CAM-practices against cancer, but none of the reviews concluded a positive effect on the cancer. Reviews including data on quality of life (10) and/or reduction of side effects (12) showed promising, but yet insufficient evidence for Chinese herbal medicine against pain  and side effects of chemotherapy, and mistletoe for the improvement of quality of life.

Breast cancer was the most common single type of cancer reviewed (8 reviews), all focused on the relief of side effects, primarily by supplements containing soy/plant hormones. The use of these supplements should be discouraged due to a risk for progression of breast cancer or interference with treatment.

Conclusions

Thirty-two reviews provided reliable information on the evidence for biologically based CAM-practices for cancer or cancer related symptoms. None of the reviews concluded a positive effect on the cancer, despite the widespread use of these CAM-practices among cancer patients. There is a need for future studies on specific type of practices in relation to side effects and quality of life parameters.

Research Methods:

-Systematic reviews, meta analysis

Funding:

The research was funded by The Danish Cancer Society and the University of Southern Denmark.

OriginalsprogEngelsk
TitelICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book
Publikationsdato2010
Sider46-47
StatusUdgivet - 2010
BegivenhedICCMR 2010. 5th International Congress on Complementary Medicine Research. - Tromsø, Norge
Varighed: 19. maj 201021. maj 2010

Konference

KonferenceICCMR 2010. 5th International Congress on Complementary Medicine Research.
LandNorge
ByTromsø
Periode19/05/201021/05/2010

Fingeraftryk

Meta-Analysis
Neoplasms
Mistletoe
Plant Growth Regulators
Herbal Medicine
Quality of Life
Denmark
Dietary Supplements
Research
Vitamins
Libraries

Emneord

  • Alternativ behandling
  • kræft
  • biologiske terapier

Citer dette

Paludan-Müller, C., Lunde, A., & Johannessen, H. (2010). A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients. I ICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book (s. 46-47)
Paludan-Müller, Christine ; Lunde, Anita ; Johannessen, Helle. / A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients. ICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book. 2010. s. 46-47
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Paludan-Müller, C, Lunde, A & Johannessen, H 2010, A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients. i ICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book. s. 46-47, ICCMR 2010. 5th International Congress on Complementary Medicine Research., Tromsø, Norge, 19/05/2010.

A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients. / Paludan-Müller, Christine; Lunde, Anita; Johannessen, Helle.

ICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book. 2010. s. 46-47.

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingKonferenceabstrakt i proceedingsForskning

TY - ABST

T1 - A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients

AU - Paludan-Müller, Christine

AU - Lunde, Anita

AU - Johannessen, Helle

PY - 2010

Y1 - 2010

N2 - PurposeTo provide an overview and evaluate the evidence of biologically based CAM-practices for cancer patients. MethodsPubmed, Social Science Citation Index, AMED and the Cochrane library were systematically searched for reviews on effects of biologically based CAM-practices, including herbal remedies, vitamins and other dietary supplements, for cancer or cancer related symptoms published 2000-2008. All studies were assessed according to the SIGN hierarchy of evidence. ResultsA total of 78 reviews/meta-analyses were identified. Of these, 32 were evaluated as high-quality, whereas 46 had low levels of evidence and were excluded from further evaluation. Among the 32 high-quality reviews the most reviewed practices were soy/plant hormones (7), Chinese herbal medicine (7), antioxidants (5) and mistletoe (4). Fifteen of the 32 reviews included data on the efficacy of biologically-based CAM-practices against cancer, but none of the reviews concluded a positive effect on the cancer. Reviews including data on quality of life (10) and/or reduction of side effects (12) showed promising, but yet insufficient evidence for Chinese herbal medicine against pain  and side effects of chemotherapy, and mistletoe for the improvement of quality of life.Breast cancer was the most common single type of cancer reviewed (8 reviews), all focused on the relief of side effects, primarily by supplements containing soy/plant hormones. The use of these supplements should be discouraged due to a risk for progression of breast cancer or interference with treatment. ConclusionsThirty-two reviews provided reliable information on the evidence for biologically based CAM-practices for cancer or cancer related symptoms. None of the reviews concluded a positive effect on the cancer, despite the widespread use of these CAM-practices among cancer patients. There is a need for future studies on specific type of practices in relation to side effects and quality of life parameters.Research Methods: -Systematic reviews, meta analysisFunding: The research was funded by The Danish Cancer Society and the University of Southern Denmark.

AB - PurposeTo provide an overview and evaluate the evidence of biologically based CAM-practices for cancer patients. MethodsPubmed, Social Science Citation Index, AMED and the Cochrane library were systematically searched for reviews on effects of biologically based CAM-practices, including herbal remedies, vitamins and other dietary supplements, for cancer or cancer related symptoms published 2000-2008. All studies were assessed according to the SIGN hierarchy of evidence. ResultsA total of 78 reviews/meta-analyses were identified. Of these, 32 were evaluated as high-quality, whereas 46 had low levels of evidence and were excluded from further evaluation. Among the 32 high-quality reviews the most reviewed practices were soy/plant hormones (7), Chinese herbal medicine (7), antioxidants (5) and mistletoe (4). Fifteen of the 32 reviews included data on the efficacy of biologically-based CAM-practices against cancer, but none of the reviews concluded a positive effect on the cancer. Reviews including data on quality of life (10) and/or reduction of side effects (12) showed promising, but yet insufficient evidence for Chinese herbal medicine against pain  and side effects of chemotherapy, and mistletoe for the improvement of quality of life.Breast cancer was the most common single type of cancer reviewed (8 reviews), all focused on the relief of side effects, primarily by supplements containing soy/plant hormones. The use of these supplements should be discouraged due to a risk for progression of breast cancer or interference with treatment. ConclusionsThirty-two reviews provided reliable information on the evidence for biologically based CAM-practices for cancer or cancer related symptoms. None of the reviews concluded a positive effect on the cancer, despite the widespread use of these CAM-practices among cancer patients. There is a need for future studies on specific type of practices in relation to side effects and quality of life parameters.Research Methods: -Systematic reviews, meta analysisFunding: The research was funded by The Danish Cancer Society and the University of Southern Denmark.

KW - Alternativ behandling

KW - kræft

KW - biologiske terapier

KW - Complementary Therapies

KW - cancer

KW - Biologically based therapies

M3 - Conference abstract in proceedings

SP - 46

EP - 47

BT - ICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book

ER -

Paludan-Müller C, Lunde A, Johannessen H. A systematic literature review on reviews and meta-analyses of biologically based CAM-practices for cancer patients. I ICCMR 2010. 5th International Congress on Complementary Medicine Research. Abstract book. 2010. s. 46-47