A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate

S Heydorn, Klaus Ejner Andersen, Jeanne Duus Johansen, T Menné

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2003-Sep
OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind49
Udgave nummer3
Sider (fra-til)133-9
Antal sider6
ISSN0105-1873
StatusUdgivet - 1. sep. 2003

Fingeraftryk

Patch Tests
Irritants
Allergens
Forearm
Reading

Citer dette

@article{c4446380d04511dd9908000ea68e967b,
title = "A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate",
abstract = "Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch test elicitation reaction than patch testing with the allergen (hydroxycitronellal) alone, in patients previously patch tested positive to hydroxycitronellal. A stronger patch test elicitation reaction was defined as at least 1 day of patch test reading showing more positive patch tests (+, ++ or +++) on the forearm patch tested with 6 concentrations of SLS plus hydroxycitronellal than on the forearm tested with 6 concentrations of hydroxycitronellal alone and no day of patch test readings showing more positive tests on the hydroxycitronellal forearm. 15/20 (75{\%}) had at least 1 day of patch test reading with more positive patch tests on the forearm patch tested with SLS plus hydroxycitronellal and no day of patch test readings with more positive patch tests on the forearm tested with hydroxycitronellal (P = 0.0253). Estimation of the blood flow with laser Doppler supported these findings.",
keywords = "Adult, Aged, Allergens, Dermatitis, Allergic Contact, Double-Blind Method, Female, Humans, Irritants, Laser-Doppler Flowmetry, Male, Middle Aged, Patch Tests, Questionnaires, Severity of Illness Index, Skin, Sodium Dodecyl Sulfate, Terpenes",
author = "S Heydorn and Andersen, {Klaus Ejner} and Johansen, {Jeanne Duus} and T Menn{\'e}",
year = "2003",
month = "9",
day = "1",
language = "English",
volume = "49",
pages = "133--9",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "3",

}

A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate. / Heydorn, S; Andersen, Klaus Ejner; Johansen, Jeanne Duus; Menné, T.

I: Contact Dermatitis, Bind 49, Nr. 3, 01.09.2003, s. 133-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate

AU - Heydorn, S

AU - Andersen, Klaus Ejner

AU - Johansen, Jeanne Duus

AU - Menné, T

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch test elicitation reaction than patch testing with the allergen (hydroxycitronellal) alone, in patients previously patch tested positive to hydroxycitronellal. A stronger patch test elicitation reaction was defined as at least 1 day of patch test reading showing more positive patch tests (+, ++ or +++) on the forearm patch tested with 6 concentrations of SLS plus hydroxycitronellal than on the forearm tested with 6 concentrations of hydroxycitronellal alone and no day of patch test readings showing more positive tests on the hydroxycitronellal forearm. 15/20 (75%) had at least 1 day of patch test reading with more positive patch tests on the forearm patch tested with SLS plus hydroxycitronellal and no day of patch test readings with more positive patch tests on the forearm tested with hydroxycitronellal (P = 0.0253). Estimation of the blood flow with laser Doppler supported these findings.

AB - Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch test elicitation reaction than patch testing with the allergen (hydroxycitronellal) alone, in patients previously patch tested positive to hydroxycitronellal. A stronger patch test elicitation reaction was defined as at least 1 day of patch test reading showing more positive patch tests (+, ++ or +++) on the forearm patch tested with 6 concentrations of SLS plus hydroxycitronellal than on the forearm tested with 6 concentrations of hydroxycitronellal alone and no day of patch test readings showing more positive tests on the hydroxycitronellal forearm. 15/20 (75%) had at least 1 day of patch test reading with more positive patch tests on the forearm patch tested with SLS plus hydroxycitronellal and no day of patch test readings with more positive patch tests on the forearm tested with hydroxycitronellal (P = 0.0253). Estimation of the blood flow with laser Doppler supported these findings.

KW - Adult

KW - Aged

KW - Allergens

KW - Dermatitis, Allergic Contact

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Irritants

KW - Laser-Doppler Flowmetry

KW - Male

KW - Middle Aged

KW - Patch Tests

KW - Questionnaires

KW - Severity of Illness Index

KW - Skin

KW - Sodium Dodecyl Sulfate

KW - Terpenes

M3 - Journal article

VL - 49

SP - 133

EP - 139

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 3

ER -