A strategy to validate a selection of human effect biomarkers using adverse outcome pathways

Proof of concept for phthalates and reproductive effects

Kirsten A. Baken*, Nathalie Lambrechts, Sylvie Remy, Vicente Mustieles, Andrea Rodríguez-Carrillo, Christiana M. Neophytou, Nicolas Olea, Greet Schoeters

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

42 Downloads (Pure)

Resumé

Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.

OriginalsprogEngelsk
TidsskriftEnvironmental Research
Vol/bind175
Sider (fra-til)235-256
ISSN0013-9351
DOI
StatusUdgivet - 2019

Fingeraftryk

phthalate
Biomarkers
biomarker
Peroxisome Proliferator-Activated Receptors
Health
Epidemiology
Consumer products
Environmental Monitoring
Body fluids
Metabolites
body fluid
Toxicity
toxicology
biomonitoring
Chemical activation
epidemiology
phthalic acid
effect
Tissue
Weights and Measures

Citer dette

Baken, Kirsten A. ; Lambrechts, Nathalie ; Remy, Sylvie ; Mustieles, Vicente ; Rodríguez-Carrillo, Andrea ; Neophytou, Christiana M. ; Olea, Nicolas ; Schoeters, Greet. / A strategy to validate a selection of human effect biomarkers using adverse outcome pathways : Proof of concept for phthalates and reproductive effects. I: Environmental Research. 2019 ; Bind 175. s. 235-256.
@article{c847a88fd0d14a2fb7e648eadcc73121,
title = "A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects",
abstract = "Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.",
keywords = "Adverse outcome pathway, Effect biomarkers, Human biomonitoring, Phthalates, Reproductive toxicity",
author = "Baken, {Kirsten A.} and Nathalie Lambrechts and Sylvie Remy and Vicente Mustieles and Andrea Rodr{\'i}guez-Carrillo and Neophytou, {Christiana M.} and Nicolas Olea and Greet Schoeters",
year = "2019",
doi = "10.1016/j.envres.2019.05.013",
language = "English",
volume = "175",
pages = "235--256",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Heinemann",

}

A strategy to validate a selection of human effect biomarkers using adverse outcome pathways : Proof of concept for phthalates and reproductive effects. / Baken, Kirsten A.; Lambrechts, Nathalie; Remy, Sylvie; Mustieles, Vicente; Rodríguez-Carrillo, Andrea; Neophytou, Christiana M.; Olea, Nicolas; Schoeters, Greet.

I: Environmental Research, Bind 175, 2019, s. 235-256.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A strategy to validate a selection of human effect biomarkers using adverse outcome pathways

T2 - Proof of concept for phthalates and reproductive effects

AU - Baken, Kirsten A.

AU - Lambrechts, Nathalie

AU - Remy, Sylvie

AU - Mustieles, Vicente

AU - Rodríguez-Carrillo, Andrea

AU - Neophytou, Christiana M.

AU - Olea, Nicolas

AU - Schoeters, Greet

PY - 2019

Y1 - 2019

N2 - Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.

AB - Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.

KW - Adverse outcome pathway

KW - Effect biomarkers

KW - Human biomonitoring

KW - Phthalates

KW - Reproductive toxicity

U2 - 10.1016/j.envres.2019.05.013

DO - 10.1016/j.envres.2019.05.013

M3 - Journal article

VL - 175

SP - 235

EP - 256

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -