A role for collagen type IV in cardiovascular disease?

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Resumé

Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen (COL)4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α 1-and α 2-chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology: Heart and Circulatory Physiology
Vol/bind315
Udgave nummer3
Sider (fra-til)H610–H625
ISSN0363-6135
DOI
StatusUdgivet - 1. sep. 2018

Fingeraftryk

Collagen Type IV
Coronary Artery Disease
Single Nucleotide Polymorphism

Citer dette

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title = "A role for collagen type IV in cardiovascular disease?",
abstract = "Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen (COL)4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α 1-and α 2-chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.",
keywords = "Atherosclerosis, Basement membrane, Cardiovascular disease, Collagen type IV",
author = "Steffensen, {Lasse Bach} and Rasmussen, {Lars M}",
year = "2018",
month = "9",
day = "1",
doi = "10.1152/ajpheart.00070.2018",
language = "English",
volume = "315",
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A role for collagen type IV in cardiovascular disease? / Steffensen, Lasse Bach; Rasmussen, Lars M.

I: American Journal of Physiology: Heart and Circulatory Physiology, Bind 315, Nr. 3, 01.09.2018, s. H610–H625.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - A role for collagen type IV in cardiovascular disease?

AU - Steffensen, Lasse Bach

AU - Rasmussen, Lars M

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen (COL)4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α 1-and α 2-chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.

AB - Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen (COL)4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α 1-and α 2-chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.

KW - Atherosclerosis

KW - Basement membrane

KW - Cardiovascular disease

KW - Collagen type IV

U2 - 10.1152/ajpheart.00070.2018

DO - 10.1152/ajpheart.00070.2018

M3 - Review

C2 - 29677463

VL - 315

SP - H610–H625

JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

SN - 0363-6135

IS - 3

ER -