A protein-centric view of in vitro biological model systems for schizophrenia

Abinaya Chandrasekaran, Pia Jensen, Fadumo A. Mohamed, Madeline Lancaster, Michael E. Benros, Martin R. Larsen, Kristine K. Freude*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Schizophrenia (SCZ) is a severe brain disorder, characterized by psychotic, negative, and cognitive symptoms, affecting 1% of the population worldwide. The precise etiology of SCZ is still unknown; however, SCZ has a high heritability, and is associated with genetic, environmental, and social risk factors. Even though the genetic contribution is indisputable, the discrepancies between transcriptomics and proteomics in brain tissues are consistently challenging the field to decipher the disease pathology. Here we provide an overview of the state of the art of neuronal two-dimensional and three-dimensional model systems that can be combined with proteomics analyses to decipher specific brain pathology and detection of alternative entry points for drug development.

OriginalsprogEngelsk
TidsskriftStem Cells
ISSN1066-5099
DOI
StatusE-pub ahead of print - 25. aug. 2021

Bibliografisk note

Funding Information:
This work was supported by awards from: Innovation Fund Denmark (BrainStem: 4108‐00008B & NeuroStem) (K.K.F.) and Lundbeckfonden (Developnoid: R336‐2020‐1113) (M.R.L.). All figures were designed using Biorender.

Publisher Copyright:
©2021 The Authors. Stem Cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2021

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