A possible association between the genetic predisposition for dizygotic twinning and schizophrenia

Ulla Kläning, Carsten Bøcker Pedersen, Preben Bo Mortensen, Kirsten Ohm Kyvik, Axel Skytthe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2002-Nov-1
OriginalsprogEngelsk
TidsskriftSchizophrenia Research
Vol/bind58
Udgave nummer1
Sider (fra-til)31-35
Antal sider4
ISSN0920-9964
DOI
StatusUdgivet - 2002

Fingeraftryk

Siblings
Dizygotic Twins
Monozygotic Twins
Population

Bibliografisk note

Copyright 2002 Elsevier Science B.V.

Citer dette

Kläning, Ulla ; Pedersen, Carsten Bøcker ; Mortensen, Preben Bo ; Kyvik, Kirsten Ohm ; Skytthe, Axel. / A possible association between the genetic predisposition for dizygotic twinning and schizophrenia. I: Schizophrenia Research. 2002 ; Bind 58, Nr. 1. s. 31-35.
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title = "A possible association between the genetic predisposition for dizygotic twinning and schizophrenia",
abstract = "BACKGROUND: A previous study demonstrated a 40{\%} higher rate of schizophrenia in dizygotic twins than in the general population. The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated. METHOD: Through record linkage between The Danish Twin Register, The Danish Psychiatric Central Register, and The Danish Civil Registration System, the rate of schizophrenia in singleton siblings of dizygotic and monozygotic twins was compared with the rate in siblings of singletons. RESULTS: The rate of first admission to hospital for schizophrenia in siblings of dizygotic twins was 35{\%} greater than the rate in siblings of singletons. The result was statistically significant (p = 0.04). The rate in siblings of monozygotic twins was not increased. CONCLUSION: The results are in accordance with a theory of a linkage between genes influencing the rate of dizygotic twinning and genes influencing the threshold for developing schizophrenia.",
keywords = "Cross-Sectional Studies, Denmark, Diseases in Twins, Female, Genetic Predisposition to Disease, Humans, Male, Registries, Risk Factors, Schizophrenia, Twins, Dizygotic, Twins, Monozygotic",
author = "Ulla Kl{\"a}ning and Pedersen, {Carsten B{\o}cker} and Mortensen, {Preben Bo} and Kyvik, {Kirsten Ohm} and Axel Skytthe",
note = "Copyright 2002 Elsevier Science B.V.",
year = "2002",
doi = "10.1016/S0920-9964(01)00343-7",
language = "English",
volume = "58",
pages = "31--35",
journal = "Schizophrenia Research",
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A possible association between the genetic predisposition for dizygotic twinning and schizophrenia. / Kläning, Ulla; Pedersen, Carsten Bøcker; Mortensen, Preben Bo; Kyvik, Kirsten Ohm; Skytthe, Axel.

I: Schizophrenia Research, Bind 58, Nr. 1, 2002, s. 31-35.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A possible association between the genetic predisposition for dizygotic twinning and schizophrenia

AU - Kläning, Ulla

AU - Pedersen, Carsten Bøcker

AU - Mortensen, Preben Bo

AU - Kyvik, Kirsten Ohm

AU - Skytthe, Axel

N1 - Copyright 2002 Elsevier Science B.V.

PY - 2002

Y1 - 2002

N2 - BACKGROUND: A previous study demonstrated a 40% higher rate of schizophrenia in dizygotic twins than in the general population. The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated. METHOD: Through record linkage between The Danish Twin Register, The Danish Psychiatric Central Register, and The Danish Civil Registration System, the rate of schizophrenia in singleton siblings of dizygotic and monozygotic twins was compared with the rate in siblings of singletons. RESULTS: The rate of first admission to hospital for schizophrenia in siblings of dizygotic twins was 35% greater than the rate in siblings of singletons. The result was statistically significant (p = 0.04). The rate in siblings of monozygotic twins was not increased. CONCLUSION: The results are in accordance with a theory of a linkage between genes influencing the rate of dizygotic twinning and genes influencing the threshold for developing schizophrenia.

AB - BACKGROUND: A previous study demonstrated a 40% higher rate of schizophrenia in dizygotic twins than in the general population. The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated. METHOD: Through record linkage between The Danish Twin Register, The Danish Psychiatric Central Register, and The Danish Civil Registration System, the rate of schizophrenia in singleton siblings of dizygotic and monozygotic twins was compared with the rate in siblings of singletons. RESULTS: The rate of first admission to hospital for schizophrenia in siblings of dizygotic twins was 35% greater than the rate in siblings of singletons. The result was statistically significant (p = 0.04). The rate in siblings of monozygotic twins was not increased. CONCLUSION: The results are in accordance with a theory of a linkage between genes influencing the rate of dizygotic twinning and genes influencing the threshold for developing schizophrenia.

KW - Cross-Sectional Studies

KW - Denmark

KW - Diseases in Twins

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Registries

KW - Risk Factors

KW - Schizophrenia

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1016/S0920-9964(01)00343-7

DO - 10.1016/S0920-9964(01)00343-7

M3 - Journal article

C2 - 12363387

VL - 58

SP - 31

EP - 35

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1

ER -