A parametric study of effect of experimental tibialis posterior muscle pain on joint loading and muscle forces—Implications for patients with rheumatoid arthritis?

Morten Bilde Simonsen, Aysun Yurtsever, Ketill Næsborg-Andersen, Peter Derek Christian Leutscher, Kim Hørslev-Petersen, Rogerio Pessoto Hirata, Michael Skipper Andersen*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Foot pain and deformities are commonly encountered in patients with rheumatoid arthritis (RA). Likewise, Posterior tibial tendon dysfunction (PTTD) is commonly involved in development of foot and ankle abnormalities and has been reported with a prevalence in two-thirds of the RA patients. Research question: Redundancy in the physiological function between different muscles provides the central nervous system multiple options to perform the same movement but which muscles compensate for the impairment of the tibialis posterior (TP) muscle? And how does these changes affect ankle joint loading? Methods: Experimental and computational disciplines were applied to investigate changes in muscle forces as result of induced pain in the right TP muscle. Twelve healthy subjects were enrolled in the study. Experimental pain was induced in the TP by a single ultrasound graphically guided injection of 1 mL hypertonic saline (5.0% Sodium Chloride). The participants' gait was assessed by skin marker-based motion capture and force plates. Musculoskeletal models were used to investigate compensation mechanisms systematically in the lower under extremity when TP muscle was recruited less as a consequence of the induced pain. Results: Experimental TP muscle pain and simulated reduced strength caused altered muscle recruitment and made the flexor digitorum longus and flexor hallucis longus muscles compensated for the impairment of the TP muscle. Further, the resultant ankle joint force was increased as the strength of the TP muscle was reduced. Significance: The compensation mechanism observed in the present study indicate that alterations in muscle recruitment and muscle force distribution as a result of the underlying disease inflammation itself may contribute to development of chronic foot pain and deformities in patients with RA. Further studies are required to understand the role of PTTD in occurrence of those late adverse musculoskeletal manifestations aiming at search for early preventive strategies.

OriginalsprogEngelsk
TidsskriftGait and Posture
Vol/bind72
Sider (fra-til)102-108
ISSN0966-6362
DOI
StatusUdgivet - 1. jul. 2019

Fingeraftryk

Myalgia
Joints
Muscles
Foot Deformities
Chronic Pain
Central Nervous System

Citer dette

Simonsen, Morten Bilde ; Yurtsever, Aysun ; Næsborg-Andersen, Ketill ; Leutscher, Peter Derek Christian ; Hørslev-Petersen, Kim ; Hirata, Rogerio Pessoto ; Andersen, Michael Skipper. / A parametric study of effect of experimental tibialis posterior muscle pain on joint loading and muscle forces—Implications for patients with rheumatoid arthritis?. I: Gait and Posture. 2019 ; Bind 72. s. 102-108.
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title = "A parametric study of effect of experimental tibialis posterior muscle pain on joint loading and muscle forces—Implications for patients with rheumatoid arthritis?",
abstract = "Background: Foot pain and deformities are commonly encountered in patients with rheumatoid arthritis (RA). Likewise, Posterior tibial tendon dysfunction (PTTD) is commonly involved in development of foot and ankle abnormalities and has been reported with a prevalence in two-thirds of the RA patients. Research question: Redundancy in the physiological function between different muscles provides the central nervous system multiple options to perform the same movement but which muscles compensate for the impairment of the tibialis posterior (TP) muscle? And how does these changes affect ankle joint loading? Methods: Experimental and computational disciplines were applied to investigate changes in muscle forces as result of induced pain in the right TP muscle. Twelve healthy subjects were enrolled in the study. Experimental pain was induced in the TP by a single ultrasound graphically guided injection of 1 mL hypertonic saline (5.0{\%} Sodium Chloride). The participants' gait was assessed by skin marker-based motion capture and force plates. Musculoskeletal models were used to investigate compensation mechanisms systematically in the lower under extremity when TP muscle was recruited less as a consequence of the induced pain. Results: Experimental TP muscle pain and simulated reduced strength caused altered muscle recruitment and made the flexor digitorum longus and flexor hallucis longus muscles compensated for the impairment of the TP muscle. Further, the resultant ankle joint force was increased as the strength of the TP muscle was reduced. Significance: The compensation mechanism observed in the present study indicate that alterations in muscle recruitment and muscle force distribution as a result of the underlying disease inflammation itself may contribute to development of chronic foot pain and deformities in patients with RA. Further studies are required to understand the role of PTTD in occurrence of those late adverse musculoskeletal manifestations aiming at search for early preventive strategies.",
keywords = "Dysfunction, Muscle compensation, Musculoskeletal modelling, Parametric study, Tibialis posterior",
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day = "1",
doi = "10.1016/j.gaitpost.2019.06.001",
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A parametric study of effect of experimental tibialis posterior muscle pain on joint loading and muscle forces—Implications for patients with rheumatoid arthritis? / Simonsen, Morten Bilde; Yurtsever, Aysun; Næsborg-Andersen, Ketill; Leutscher, Peter Derek Christian; Hørslev-Petersen, Kim; Hirata, Rogerio Pessoto; Andersen, Michael Skipper.

I: Gait and Posture, Bind 72, 01.07.2019, s. 102-108.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A parametric study of effect of experimental tibialis posterior muscle pain on joint loading and muscle forces—Implications for patients with rheumatoid arthritis?

AU - Simonsen, Morten Bilde

AU - Yurtsever, Aysun

AU - Næsborg-Andersen, Ketill

AU - Leutscher, Peter Derek Christian

AU - Hørslev-Petersen, Kim

AU - Hirata, Rogerio Pessoto

AU - Andersen, Michael Skipper

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Foot pain and deformities are commonly encountered in patients with rheumatoid arthritis (RA). Likewise, Posterior tibial tendon dysfunction (PTTD) is commonly involved in development of foot and ankle abnormalities and has been reported with a prevalence in two-thirds of the RA patients. Research question: Redundancy in the physiological function between different muscles provides the central nervous system multiple options to perform the same movement but which muscles compensate for the impairment of the tibialis posterior (TP) muscle? And how does these changes affect ankle joint loading? Methods: Experimental and computational disciplines were applied to investigate changes in muscle forces as result of induced pain in the right TP muscle. Twelve healthy subjects were enrolled in the study. Experimental pain was induced in the TP by a single ultrasound graphically guided injection of 1 mL hypertonic saline (5.0% Sodium Chloride). The participants' gait was assessed by skin marker-based motion capture and force plates. Musculoskeletal models were used to investigate compensation mechanisms systematically in the lower under extremity when TP muscle was recruited less as a consequence of the induced pain. Results: Experimental TP muscle pain and simulated reduced strength caused altered muscle recruitment and made the flexor digitorum longus and flexor hallucis longus muscles compensated for the impairment of the TP muscle. Further, the resultant ankle joint force was increased as the strength of the TP muscle was reduced. Significance: The compensation mechanism observed in the present study indicate that alterations in muscle recruitment and muscle force distribution as a result of the underlying disease inflammation itself may contribute to development of chronic foot pain and deformities in patients with RA. Further studies are required to understand the role of PTTD in occurrence of those late adverse musculoskeletal manifestations aiming at search for early preventive strategies.

AB - Background: Foot pain and deformities are commonly encountered in patients with rheumatoid arthritis (RA). Likewise, Posterior tibial tendon dysfunction (PTTD) is commonly involved in development of foot and ankle abnormalities and has been reported with a prevalence in two-thirds of the RA patients. Research question: Redundancy in the physiological function between different muscles provides the central nervous system multiple options to perform the same movement but which muscles compensate for the impairment of the tibialis posterior (TP) muscle? And how does these changes affect ankle joint loading? Methods: Experimental and computational disciplines were applied to investigate changes in muscle forces as result of induced pain in the right TP muscle. Twelve healthy subjects were enrolled in the study. Experimental pain was induced in the TP by a single ultrasound graphically guided injection of 1 mL hypertonic saline (5.0% Sodium Chloride). The participants' gait was assessed by skin marker-based motion capture and force plates. Musculoskeletal models were used to investigate compensation mechanisms systematically in the lower under extremity when TP muscle was recruited less as a consequence of the induced pain. Results: Experimental TP muscle pain and simulated reduced strength caused altered muscle recruitment and made the flexor digitorum longus and flexor hallucis longus muscles compensated for the impairment of the TP muscle. Further, the resultant ankle joint force was increased as the strength of the TP muscle was reduced. Significance: The compensation mechanism observed in the present study indicate that alterations in muscle recruitment and muscle force distribution as a result of the underlying disease inflammation itself may contribute to development of chronic foot pain and deformities in patients with RA. Further studies are required to understand the role of PTTD in occurrence of those late adverse musculoskeletal manifestations aiming at search for early preventive strategies.

KW - Dysfunction

KW - Muscle compensation

KW - Musculoskeletal modelling

KW - Parametric study

KW - Tibialis posterior

U2 - 10.1016/j.gaitpost.2019.06.001

DO - 10.1016/j.gaitpost.2019.06.001

M3 - Journal article

VL - 72

SP - 102

EP - 108

JO - Gait & Posture

JF - Gait & Posture

SN - 0966-6362

ER -