A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography

Helle Precht, Alexander Broersen, Pieter H Kitslaar, Jouke Dijkstra, Oke Gerke, Jesper Thygesen, Kenneth Egstrup, Peter Mygind Leth, Michael Hardt-Madsen, Bjarne Nielsen, Erling Falk, Jess Lambrechtsen

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

PURPOSE: Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology.

RESULTS: In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison. The results from the comparison using the alignment procedure showed overall that the calcified plaques seem to be overestimated by PMCTA and underestimated by OCT.

CONCLUSIONS: The 3D fusion approach, aligning the images of PMCTA, OCT and histopathology as gold standard allowed for a slice-based comparison of the different modalities. The results showed that PMCTA overestimates the calcified plaques while OCT underestimates these, compared to histopathology.

OriginalsprogEngelsk
TidsskriftCardiovascular Pathology
Vol/bind39
Sider (fra-til)25-29
ISSN1054-8807
DOI
StatusUdgivet - mar. 2019

Fingeraftryk

Optical Coherence Tomography
Computed Tomography Angiography

Citer dette

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title = "A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography",
abstract = "PURPOSE: Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology.RESULTS: In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison. The results from the comparison using the alignment procedure showed overall that the calcified plaques seem to be overestimated by PMCTA and underestimated by OCT.CONCLUSIONS: The 3D fusion approach, aligning the images of PMCTA, OCT and histopathology as gold standard allowed for a slice-based comparison of the different modalities. The results showed that PMCTA overestimates the calcified plaques while OCT underestimates these, compared to histopathology.",
keywords = "Alignment, Calcified coronary plaques, Histopathology, Optical coherence tomography, Postmortem-computed tomography angiography",
author = "Helle Precht and Alexander Broersen and Kitslaar, {Pieter H} and Jouke Dijkstra and Oke Gerke and Jesper Thygesen and Kenneth Egstrup and Leth, {Peter Mygind} and Michael Hardt-Madsen and Bjarne Nielsen and Erling Falk and Jess Lambrechtsen",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2019",
month = "3",
doi = "10.1016/j.carpath.2018.11.005",
language = "English",
volume = "39",
pages = "25--29",
journal = "Cardiovascular Pathology",
issn = "1054-8807",
publisher = "Elsevier",

}

A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography. / Precht, Helle; Broersen, Alexander; Kitslaar, Pieter H; Dijkstra, Jouke; Gerke, Oke; Thygesen, Jesper; Egstrup, Kenneth; Leth, Peter Mygind; Hardt-Madsen, Michael; Nielsen, Bjarne; Falk, Erling; Lambrechtsen, Jess.

I: Cardiovascular Pathology, Bind 39, 03.2019, s. 25-29.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography

AU - Precht, Helle

AU - Broersen, Alexander

AU - Kitslaar, Pieter H

AU - Dijkstra, Jouke

AU - Gerke, Oke

AU - Thygesen, Jesper

AU - Egstrup, Kenneth

AU - Leth, Peter Mygind

AU - Hardt-Madsen, Michael

AU - Nielsen, Bjarne

AU - Falk, Erling

AU - Lambrechtsen, Jess

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/3

Y1 - 2019/3

N2 - PURPOSE: Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology.RESULTS: In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison. The results from the comparison using the alignment procedure showed overall that the calcified plaques seem to be overestimated by PMCTA and underestimated by OCT.CONCLUSIONS: The 3D fusion approach, aligning the images of PMCTA, OCT and histopathology as gold standard allowed for a slice-based comparison of the different modalities. The results showed that PMCTA overestimates the calcified plaques while OCT underestimates these, compared to histopathology.

AB - PURPOSE: Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology.RESULTS: In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison. The results from the comparison using the alignment procedure showed overall that the calcified plaques seem to be overestimated by PMCTA and underestimated by OCT.CONCLUSIONS: The 3D fusion approach, aligning the images of PMCTA, OCT and histopathology as gold standard allowed for a slice-based comparison of the different modalities. The results showed that PMCTA overestimates the calcified plaques while OCT underestimates these, compared to histopathology.

KW - Alignment

KW - Calcified coronary plaques

KW - Histopathology

KW - Optical coherence tomography

KW - Postmortem-computed tomography angiography

U2 - 10.1016/j.carpath.2018.11.005

DO - 10.1016/j.carpath.2018.11.005

M3 - Review

VL - 39

SP - 25

EP - 29

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

SN - 1054-8807

ER -