A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels

Marco Medici, Wendy M van der Deure, Michael Verbiest, Sita H Vermeulen, Pia S Hansen, Lambertus A Kiemeney, Ad R M M Hermus, Monique M Breteler, Albert Hofman, Laszlo Hegedüs, Kirsten Ohm Kyvik, Martin den Heijer, André G Uitterlinden, Theo J Visser, Robin P Peeters

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Abstrakt

Minor variation in serum thyroid hormone (TH) levels can have important effects on various clinical endpoints. Although 45-65% of the inter-individual variation in serum TH levels is due to genetic factors, the causative genes are not well established. We therefore studied the effects of genetic variation in 68 TH pathway genes on serum TSH and free thyroxine (FT(4)) levels.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind164
Udgave nummer5
Sider (fra-til)781-8
Antal sider8
ISSN0804-4643
DOI
StatusUdgivet - 2011

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