A large cohort study of the effects of Lewis, ABO, 13 other blood groups, and secretor status on COVID-19 susceptibility, severity, and long COVID-19

Camous Moslemi*, Susanne Sækmose, Rune Larsen, Thorsten Brodersen, Maria Didriksen, Henrik Hjalgrim, Karina Banasik, Kaspar R. Nielsen, Mie T. Bruun, Joseph Dowsett, Kathrine A. Kasperen, Susan Mikkelsen, Thomas F. Hansen, Henrik Ullum, Christian Erikstrup, Martin L. Olsson, Sisse R. Ostrowski, Ole B. Pedersen


Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

45 Downloads (Pure)


Background: Previous studies have reported Blood type O to confer a lower risk of SARS-CoV-2 infection, while secretor status and other blood groups have been suspected to have a similar effect as well. Study design and methods: To determine whether any other blood groups influence testing positive for SARS-CoV-2, COVID-19 severity, or prolonged COVID-19, we used a large cohort of 650,156 Danish blood donors with varying available data for secretor status and blood groups ABO, Rh, Colton, Duffy, Diego, Dombrock, Kell, Kidd, Knops, Lewis, Lutheran, MNS, P1PK, Vel, and Yt. Of these, 36,068 tested positive for SARS-CoV-2 whereas 614,088 tested negative between 2020-02-17 and 2021-08-04. Associations between infection and blood groups were assessed using logistic regression models with sex and age as covariates. Results: The Lewis blood group antigen Lea displayed strongly reduced SARS-CoV-2 susceptibility OR 0.85 CI[0.79–0.93] p <.001. Compared to blood type O, the blood types B, A, and AB were found more susceptible toward infection with ORs 1.1 CI[1.06–1.14] p <.001, 1.17 CI[1.14–1.2] p <.001, and 1.2 CI[1.14–1.26] p <.001, respectively. No susceptibility associations were found for the other 13 blood groups investigated. There was no association between any blood groups and COVID-19 hospitalization or long COVID-19. No secretor status associations were found. Discussion: This study uncovers a new association to reduced SARS-CoV-2 susceptibility for Lewis type Lea and confirms the previous link to blood group O. The new association to Lea could be explained by a link between mucosal microbiome and SARS-CoV-2.

Udgave nummer1
Sider (fra-til)47-58
StatusUdgivet - jan. 2023

Bibliografisk note

Funding Information:
We thank the Danish Blood Donor Study for making data available for the research done in this publication. The collection of questionnaires was supported by Independent Research Fund Denmark, project number 0214‐00127B.

Publisher Copyright:
© 2022 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.


Dyk ned i forskningsemnerne om 'A large cohort study of the effects of Lewis, ABO, 13 other blood groups, and secretor status on COVID-19 susceptibility, severity, and long COVID-19'. Sammen danner de et unikt fingeraftryk.