A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans

Benoit Vanhollebeke, Géraldine De Muylder, Marianne J Nielsen, Annette Pays, Patricia Tebabi, Marc Dieu, Martine Raes, Soren K Moestrup, Etienne Pays

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Abstract

    The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein. We report that this process is mediated by a parasite glycoprotein receptor, which binds the haptoglobin-hemoglobin complex with high affinity for the uptake and incorporation of heme into intracellular hemoproteins. In mice, this receptor was required for optimal parasite growth and the resistance of parasites to the oxidative burst by host macrophages. In humans, the trypanosome receptor also recognized the complex between hemoglobin and haptoglobin-related protein, which explains its ability to capture trypanolytic HDLs. Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite.

    OriginalsprogEngelsk
    TidsskriftScience
    Vol/bind320
    Udgave nummer5876
    Sider (fra-til)677-81
    Antal sider5
    ISSN0036-8075
    DOI
    StatusUdgivet - 2008

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans'. Sammen danner de et unikt fingeraftryk.

    Citationsformater