A general measles vaccination campaign in urban Guinea-Bissau: Comparing child mortality among participants and non-participants

S. Byberg*, Sanne Marie Thysen, A Rodrigues, C Martins, C. Cabral, M. Careme, P Aaby, C. S. Benn, A. B. Fisker

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background Measles vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of measles vaccine. We compared mortality one year after the December 2012 measles vaccination campaign in Bissau city for children who received campaign measles vaccine with children who did not receive campaign measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project's study area who received measles vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign measles vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving measles vaccine during the 2012 campaign, especially for girls and children with previous routine measles vaccination. Measles vaccination campaigns may be an effective way of improving child survival.

OriginalsprogEngelsk
TidsskriftVaccine
Vol/bind35
Udgave nummer1
Sider (fra-til)33-39
ISSN0264-410X
DOI
StatusUdgivet - 2017

Fingeraftryk

Guinea-Bissau
Immunization Programs
Child Mortality
Measles
vaccination
vaccines
Health
Proportional Hazards Models
Health Personnel

Citer dette

@article{ad5af911ddc149fa9e7d659a656c442f,
title = "A general measles vaccination campaign in urban Guinea-Bissau: Comparing child mortality among participants and non-participants",
abstract = "Background Measles vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of measles vaccine. We compared mortality one year after the December 2012 measles vaccination campaign in Bissau city for children who received campaign measles vaccine with children who did not receive campaign measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project's study area who received measles vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85{\%}) received campaign measles vaccination and 1006 (15{\%}) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing measles vaccinated versus unvaccinated was 0.28 (95{\%} CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving measles vaccine during the 2012 campaign, especially for girls and children with previous routine measles vaccination. Measles vaccination campaigns may be an effective way of improving child survival.",
keywords = "Child survival, Guinea-Bissau, Measles vaccination campaign, Measles vaccine, Non-specific/heterologous effects, Supplementary immunization activities",
author = "S. Byberg and Thysen, {Sanne Marie} and A Rodrigues and C Martins and C. Cabral and M. Careme and P Aaby and Benn, {C. S.} and Fisker, {A. B.}",
year = "2017",
doi = "10.1016/j.vaccine.2016.11.049",
language = "English",
volume = "35",
pages = "33--39",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "1",

}

A general measles vaccination campaign in urban Guinea-Bissau : Comparing child mortality among participants and non-participants. / Byberg, S.; Thysen, Sanne Marie; Rodrigues, A; Martins, C; Cabral, C.; Careme, M.; Aaby, P; Benn, C. S.; Fisker, A. B.

I: Vaccine, Bind 35, Nr. 1, 2017, s. 33-39.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A general measles vaccination campaign in urban Guinea-Bissau

T2 - Comparing child mortality among participants and non-participants

AU - Byberg, S.

AU - Thysen, Sanne Marie

AU - Rodrigues, A

AU - Martins, C

AU - Cabral, C.

AU - Careme, M.

AU - Aaby, P

AU - Benn, C. S.

AU - Fisker, A. B.

PY - 2017

Y1 - 2017

N2 - Background Measles vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of measles vaccine. We compared mortality one year after the December 2012 measles vaccination campaign in Bissau city for children who received campaign measles vaccine with children who did not receive campaign measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project's study area who received measles vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign measles vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving measles vaccine during the 2012 campaign, especially for girls and children with previous routine measles vaccination. Measles vaccination campaigns may be an effective way of improving child survival.

AB - Background Measles vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of measles vaccine. We compared mortality one year after the December 2012 measles vaccination campaign in Bissau city for children who received campaign measles vaccine with children who did not receive campaign measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project's study area who received measles vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign measles vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving measles vaccine during the 2012 campaign, especially for girls and children with previous routine measles vaccination. Measles vaccination campaigns may be an effective way of improving child survival.

KW - Child survival

KW - Guinea-Bissau

KW - Measles vaccination campaign

KW - Measles vaccine

KW - Non-specific/heterologous effects

KW - Supplementary immunization activities

U2 - 10.1016/j.vaccine.2016.11.049

DO - 10.1016/j.vaccine.2016.11.049

M3 - Journal article

C2 - 27890397

AN - SCOPUS:84999791275

VL - 35

SP - 33

EP - 39

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 1

ER -