A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin

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Abstrakt

The aim of this study was to determine the association between the renal clearance (CL(renal)) of metformin in healthy Caucasian volunteers and the single-nucleotide polymorphism (SNP) c.808G>T (rs316019) in OCT2 as well as the relevance of the gene-gene interactions between this SNP and (a) the promoter SNP g.-66T>C (rs2252281) in MATE1 and (b) the OCT1 reduced-function diplotypes.
OriginalsprogEngelsk
TidsskriftPharmacogenetics and Genomics
Vol/bind23
Udgave nummer10
Sider (fra-til)526-534
ISSN1744-6872
DOI
StatusUdgivet - 2013

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