A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
The aim of this study was to determine the association between the renal clearance (CL(renal)) of metformin in healthy Caucasian volunteers and the single-nucleotide polymorphism (SNP) c.808G>T (rs316019) in OCT2 as well as the relevance of the gene-gene interactions between this SNP and (a) the promoter SNP g.-66T>C (rs2252281) in MATE1 and (b) the OCT1 reduced-function diplotypes.
Hougaard Christensen, M. M., Pedersen, R. S., Stage, T. B., Brasch-Andersen, C., Nielsen, F., Damkier, P., Beck-Nielsen, H., & Brøsen, K. (2013). A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin. Pharmacogenetics and Genomics, 23(10), 526-534. https://doi.org/10.1097/FPC.0b013e328364a57d