A Danish Twin Study of Schizophrenia Liability: Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons

Ulla Kläning, Susan L Trumbetta, Irving I Gottesman, Axel Skytthe, Kirsten O Kyvik, Aksel Bertelsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region.
OriginalsprogEngelsk
TidsskriftBehavior Genetics
Vol/bind46
Udgave nummer2
Sider (fra-til)193-204
ISSN0001-8244
DOI
StatusUdgivet - 2016

Fingeraftryk

Psychotic Affective Disorders
Twin Studies
liability
environmental factor
biometry
environmental factors
interviews
public health
Interviews
behavior disorders
Prenatal Care
International Classification of Diseases
comparison
schizophrenia
Public Health

Emneord

  • Affective psychoses
  • Denmark
  • Endophenotype
  • Genetics
  • ICD-10
  • Schizophrenia
  • Twins

Citer dette

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abstract = "We studied schizophrenia liability in a Danish population-based sample of 44 twin pairs (13 MZ, 31 DZ, SS plus OS) in order to replicate previous twin study findings using contemporary diagnostic criteria, to examine genetic liability shared between schizophrenia and other disorders, and to explore whether variance in schizophrenia liability attributable to environmental factors may have decreased with successive cohorts exposed to improvements in public health. ICD-10 diagnoses were determined by clinical interview. Although the best-fitting, most parsimonious biometric model of schizophrenia liability specified variance attributable to additive genetic and non-shared environmental factors, this model did not differ significantly from a model that also included non-additive genetic factors, consistent with recent interview-based twin studies. Schizophrenia showed strong genetic links to other psychotic disorders but much less so for the broader category of psychiatric disorders in general. We also observed a marginally significant decline in schizophrenia variance attributable to environmental factors over successive Western European cohorts, consistent perhaps with improvements in diagnosis and in prenatal and perinatal care and with a secular decline in the prevalence of schizophrenia in that region.",
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A Danish Twin Study of Schizophrenia Liability : Investigation from Interviewed Twins for Genetic Links to Affective Psychoses and for Cross-Cohort Comparisons. / Kläning, Ulla; Trumbetta, Susan L; Gottesman, Irving I; Skytthe, Axel; Kyvik, Kirsten O; Bertelsen, Aksel.

I: Behavior Genetics, Bind 46, Nr. 2, 2016, s. 193-204.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Bertelsen, Aksel

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