A Danish population based twin study on general heath in the elderly

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Resumé

Objectives: To study the relative influence of genetic and environmental factors on self-rated health and hospitalization patterns in the elderly. Methods: Asurvey among all 3,099 Danish twins ages 75 years and older identified in the Danish Twin Registry. An interviewwas conducted with 77% of the twins. The number of hospitalizations in the previous 18 years was obtained through register linkage, thereby obtaining health information on 96% of the study population, including all nonresponders. Results: Structural equation modeling suggested that approximately a quarter of the variation in the liability to self-reported health and the number of hospitalizations could be attributed to genetic factors. The remaining variationwas most likely due to nonfamilial environment. Analyses of the hospitalization patterns of proxy responders and nonresponders suggest that the estimates of the genetic influence on health outcomes in the study are conservative. Discussion: The present study indicates that variation in general health among the elderly is partly explained by genetic factors.
OriginalsprogEngelsk
TidsskriftJournal of Aging and Health
Vol/bind11
Udgave nummer1
Sider (fra-til)49-64
ISSN0898-2643
DOI
StatusUdgivet - 1999

Fingeraftryk

Twin Studies
Health
Population
Proxy
Registries
Outcome Assessment (Health Care)

Citer dette

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title = "A Danish population based twin study on general heath in the elderly",
abstract = "Objectives: To study the relative influence of genetic and environmental factors on self-rated health and hospitalization patterns in the elderly. Methods: Asurvey among all 3,099 Danish twins ages 75 years and older identified in the Danish Twin Registry. An interviewwas conducted with 77{\%} of the twins. The number of hospitalizations in the previous 18 years was obtained through register linkage, thereby obtaining health information on 96{\%} of the study population, including all nonresponders. Results: Structural equation modeling suggested that approximately a quarter of the variation in the liability to self-reported health and the number of hospitalizations could be attributed to genetic factors. The remaining variationwas most likely due to nonfamilial environment. Analyses of the hospitalization patterns of proxy responders and nonresponders suggest that the estimates of the genetic influence on health outcomes in the study are conservative. Discussion: The present study indicates that variation in general health among the elderly is partly explained by genetic factors.",
author = "Kaare Christensen and Holm, {Niels Vilstrup} and Matt McGue and L. Corder and Vaupel, {James W.}",
year = "1999",
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A Danish population based twin study on general heath in the elderly. / Christensen, Kaare; Holm, Niels Vilstrup; McGue, Matt; Corder, L.; Vaupel, James W.

I: Journal of Aging and Health, Bind 11, Nr. 1, 1999, s. 49-64.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

TY - JOUR

T1 - A Danish population based twin study on general heath in the elderly

AU - Christensen, Kaare

AU - Holm, Niels Vilstrup

AU - McGue, Matt

AU - Corder, L.

AU - Vaupel, James W.

PY - 1999

Y1 - 1999

N2 - Objectives: To study the relative influence of genetic and environmental factors on self-rated health and hospitalization patterns in the elderly. Methods: Asurvey among all 3,099 Danish twins ages 75 years and older identified in the Danish Twin Registry. An interviewwas conducted with 77% of the twins. The number of hospitalizations in the previous 18 years was obtained through register linkage, thereby obtaining health information on 96% of the study population, including all nonresponders. Results: Structural equation modeling suggested that approximately a quarter of the variation in the liability to self-reported health and the number of hospitalizations could be attributed to genetic factors. The remaining variationwas most likely due to nonfamilial environment. Analyses of the hospitalization patterns of proxy responders and nonresponders suggest that the estimates of the genetic influence on health outcomes in the study are conservative. Discussion: The present study indicates that variation in general health among the elderly is partly explained by genetic factors.

AB - Objectives: To study the relative influence of genetic and environmental factors on self-rated health and hospitalization patterns in the elderly. Methods: Asurvey among all 3,099 Danish twins ages 75 years and older identified in the Danish Twin Registry. An interviewwas conducted with 77% of the twins. The number of hospitalizations in the previous 18 years was obtained through register linkage, thereby obtaining health information on 96% of the study population, including all nonresponders. Results: Structural equation modeling suggested that approximately a quarter of the variation in the liability to self-reported health and the number of hospitalizations could be attributed to genetic factors. The remaining variationwas most likely due to nonfamilial environment. Analyses of the hospitalization patterns of proxy responders and nonresponders suggest that the estimates of the genetic influence on health outcomes in the study are conservative. Discussion: The present study indicates that variation in general health among the elderly is partly explained by genetic factors.

U2 - 10.1177/089826439901100103

DO - 10.1177/089826439901100103

M3 - Journal article

VL - 11

SP - 49

EP - 64

JO - Journal of Aging and Health

JF - Journal of Aging and Health

SN - 0898-2643

IS - 1

ER -