A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids

Liang Xu, Steven W Plouffe, Jenny Chong, Jesper Wengel, Dong Wang

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.
OriginalsprogEngelsk
TidsskriftAngewandte Chemie International Edition
Vol/bind52
Udgave nummer47
Sider (fra-til)12341-12345
ISSN1433-7851
DOI
StatusUdgivet - 2013

Fingeraftryk Dyk ned i forskningsemnerne om 'A chemical perspective on transcriptional fidelity dominant contributions of sugar integrity revealed by unlocked nucleic acids'. Sammen danner de et unikt fingeraftryk.

Citationsformater