A changing landscape

Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006–2015

Anna-Marie Bloch Münster, Torsten Bloch Rasmussen, Anne Mette Falstie-Jensen, Louise Harboe, G Stynes, Lars Dybro, Morten Lock Hansen, Axel Brandes, Erik Lerkevang Grove, S.P. Johnsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available. Objectives: To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015. Patients/Methods: Using nationwide health care registries, we calculated yearly hospitalization rates for first-time VTE from 2006 to 2015. The rates were standardized to the age and sex distribution in 2006. Based on the hospitalization and prescription history of each patient, we assessed the risk profile and evaluated changes over time. Results: We identified 67,426 patients with a first-time VTE hospitalization. The age- and sex-standardized incidence rate increased from 12.6 (95% CI: 12.3–12.9) per 10,000 person years at risk in 2006 to 15.1 (95% CI: 14.7–15.4) in 2015, corresponding to an increase of 19.8%. The increase was due to a 73.9% increase in the standardized incidence rate of pulmonary embolism (PE), whereas no increase was observed for deep vein thrombosis. The risk profile changed with an increasing proportion of elderly patients and patients with comorbidity (proportion of patients with a Charlson's Comorbidity Index score of ≥1). Conclusions: The hospitalization rate of first-time VTE, and particularly PE, has increased substantially within the last decade in Denmark. In addition, the risk profile of the VTE population has changed with more elderly and more patients with comorbidity being diagnosed. Further efforts are warranted to explore the changes in VTE epidemiology and the clinical implications.

OriginalsprogEngelsk
TidsskriftThrombosis Research
Vol/bind176
Sider (fra-til)46-53
ISSN0049-3848
DOI
StatusUdgivet - apr. 2019

Fingeraftryk

Incidence
Comorbidity
Denmark
Age Distribution
Population
Prescriptions
Registries
Epidemiology
Public Health
Delivery of Health Care

Citer dette

Münster, Anna-Marie Bloch ; Rasmussen, Torsten Bloch ; Falstie-Jensen, Anne Mette ; Harboe, Louise ; Stynes, G ; Dybro, Lars ; Hansen, Morten Lock ; Brandes, Axel ; Grove, Erik Lerkevang ; Johnsen, S.P. / A changing landscape : Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006–2015. I: Thrombosis Research. 2019 ; Bind 176. s. 46-53.
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title = "A changing landscape: Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006–2015",
abstract = "Background: Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available. Objectives: To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015. Patients/Methods: Using nationwide health care registries, we calculated yearly hospitalization rates for first-time VTE from 2006 to 2015. The rates were standardized to the age and sex distribution in 2006. Based on the hospitalization and prescription history of each patient, we assessed the risk profile and evaluated changes over time. Results: We identified 67,426 patients with a first-time VTE hospitalization. The age- and sex-standardized incidence rate increased from 12.6 (95{\%} CI: 12.3–12.9) per 10,000 person years at risk in 2006 to 15.1 (95{\%} CI: 14.7–15.4) in 2015, corresponding to an increase of 19.8{\%}. The increase was due to a 73.9{\%} increase in the standardized incidence rate of pulmonary embolism (PE), whereas no increase was observed for deep vein thrombosis. The risk profile changed with an increasing proportion of elderly patients and patients with comorbidity (proportion of patients with a Charlson's Comorbidity Index score of ≥1). Conclusions: The hospitalization rate of first-time VTE, and particularly PE, has increased substantially within the last decade in Denmark. In addition, the risk profile of the VTE population has changed with more elderly and more patients with comorbidity being diagnosed. Further efforts are warranted to explore the changes in VTE epidemiology and the clinical implications.",
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A changing landscape : Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006–2015. / Münster, Anna-Marie Bloch; Rasmussen, Torsten Bloch; Falstie-Jensen, Anne Mette; Harboe, Louise; Stynes, G; Dybro, Lars; Hansen, Morten Lock; Brandes, Axel; Grove, Erik Lerkevang; Johnsen, S.P.

I: Thrombosis Research, Bind 176, 04.2019, s. 46-53.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A changing landscape

T2 - Temporal trends in incidence and characteristics of patients hospitalized with venous thromboembolism 2006–2015

AU - Münster, Anna-Marie Bloch

AU - Rasmussen, Torsten Bloch

AU - Falstie-Jensen, Anne Mette

AU - Harboe, Louise

AU - Stynes, G

AU - Dybro, Lars

AU - Hansen, Morten Lock

AU - Brandes, Axel

AU - Grove, Erik Lerkevang

AU - Johnsen, S.P.

PY - 2019/4

Y1 - 2019/4

N2 - Background: Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available. Objectives: To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015. Patients/Methods: Using nationwide health care registries, we calculated yearly hospitalization rates for first-time VTE from 2006 to 2015. The rates were standardized to the age and sex distribution in 2006. Based on the hospitalization and prescription history of each patient, we assessed the risk profile and evaluated changes over time. Results: We identified 67,426 patients with a first-time VTE hospitalization. The age- and sex-standardized incidence rate increased from 12.6 (95% CI: 12.3–12.9) per 10,000 person years at risk in 2006 to 15.1 (95% CI: 14.7–15.4) in 2015, corresponding to an increase of 19.8%. The increase was due to a 73.9% increase in the standardized incidence rate of pulmonary embolism (PE), whereas no increase was observed for deep vein thrombosis. The risk profile changed with an increasing proportion of elderly patients and patients with comorbidity (proportion of patients with a Charlson's Comorbidity Index score of ≥1). Conclusions: The hospitalization rate of first-time VTE, and particularly PE, has increased substantially within the last decade in Denmark. In addition, the risk profile of the VTE population has changed with more elderly and more patients with comorbidity being diagnosed. Further efforts are warranted to explore the changes in VTE epidemiology and the clinical implications.

AB - Background: Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available. Objectives: To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015. Patients/Methods: Using nationwide health care registries, we calculated yearly hospitalization rates for first-time VTE from 2006 to 2015. The rates were standardized to the age and sex distribution in 2006. Based on the hospitalization and prescription history of each patient, we assessed the risk profile and evaluated changes over time. Results: We identified 67,426 patients with a first-time VTE hospitalization. The age- and sex-standardized incidence rate increased from 12.6 (95% CI: 12.3–12.9) per 10,000 person years at risk in 2006 to 15.1 (95% CI: 14.7–15.4) in 2015, corresponding to an increase of 19.8%. The increase was due to a 73.9% increase in the standardized incidence rate of pulmonary embolism (PE), whereas no increase was observed for deep vein thrombosis. The risk profile changed with an increasing proportion of elderly patients and patients with comorbidity (proportion of patients with a Charlson's Comorbidity Index score of ≥1). Conclusions: The hospitalization rate of first-time VTE, and particularly PE, has increased substantially within the last decade in Denmark. In addition, the risk profile of the VTE population has changed with more elderly and more patients with comorbidity being diagnosed. Further efforts are warranted to explore the changes in VTE epidemiology and the clinical implications.

KW - Epidemiology

KW - Incidence

KW - Peep vein thrombosis

KW - Pulmonary embolism

KW - Venous thromboembolism

U2 - 10.1016/j.thromres.2019.02.009

DO - 10.1016/j.thromres.2019.02.009

M3 - Journal article

VL - 176

SP - 46

EP - 53

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

ER -