A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development

Jordi Julvez, George Davey Smith, Susan M Ring, Philippe Grandjean

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Genetic predisposition may affect neurodevelopmental outcomes of prenatal methylmercury exposure. We examined suspected heterogeneities for modification of exposure-related neurodevelopment in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, 1991-2000), Bristol, United Kingdom. A subgroup (n = 1127 from a pilot study and 1045 from the present study) was identified based on the availability of the mercury concentration of cord tissue as a measure of prenatal methylmercury exposure, data on 247 single-nucleotide polymorphisms (SNPs), as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores. Log10-transformed mercury concentration was positively associated with IQ, but adjustment confounding cofactors attenuated this association. Enhanced interaction with methylmercury was replicated in the new study for the minor allele of rs1042838 (progesterone receptor) (Beta; 95% Confidence Interval) = (-11.8; -23.0, -0.6) (P-for-interaction = 0.004) and weakly for rs662 (paraoxonase 1) (-3.6; -11.4, 4.3) (P = 0.117). In the joint sample, new interacting single-nucleotide polymorphisms (SNPs) were discovered in relation to superoxide dismutase 2, ATP binding cassette subfamily A member 1, and metallothionein 1M genes. While the low-level prenatal exposure to methylmercury was not associated with child cognition, progesterone receptor rs1042838 minor alleles revealed a negative association of mercury exposure with IQ.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
ISSN0002-9262
DOI
StatusE-pub ahead of print - 26 jun. 2019

Fingeraftryk

Cohort Studies
Mercury
Progesterone Receptors
Single Nucleotide Polymorphism
Alleles
Aryldialkylphosphatase
Social Adjustment
Wechsler Scales
Metallothionein
Cognition
Longitudinal Studies
Joints
Parents
Confidence Intervals

Citer dette

@article{3cd9c5ad04b44514bd3f859cf3df16c1,
title = "A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development",
abstract = "Genetic predisposition may affect neurodevelopmental outcomes of prenatal methylmercury exposure. We examined suspected heterogeneities for modification of exposure-related neurodevelopment in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, 1991-2000), Bristol, United Kingdom. A subgroup (n = 1127 from a pilot study and 1045 from the present study) was identified based on the availability of the mercury concentration of cord tissue as a measure of prenatal methylmercury exposure, data on 247 single-nucleotide polymorphisms (SNPs), as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores. Log10-transformed mercury concentration was positively associated with IQ, but adjustment confounding cofactors attenuated this association. Enhanced interaction with methylmercury was replicated in the new study for the minor allele of rs1042838 (progesterone receptor) (Beta; 95{\%} Confidence Interval) = (-11.8; -23.0, -0.6) (P-for-interaction = 0.004) and weakly for rs662 (paraoxonase 1) (-3.6; -11.4, 4.3) (P = 0.117). In the joint sample, new interacting single-nucleotide polymorphisms (SNPs) were discovered in relation to superoxide dismutase 2, ATP binding cassette subfamily A member 1, and metallothionein 1M genes. While the low-level prenatal exposure to methylmercury was not associated with child cognition, progesterone receptor rs1042838 minor alleles revealed a negative association of mercury exposure with IQ.",
author = "Jordi Julvez and Smith, {George Davey} and Ring, {Susan M} and Philippe Grandjean",
year = "2019",
month = "6",
day = "26",
doi = "10.1093/aje/kwz156",
language = "English",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Heinemann",

}

A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development. / Julvez, Jordi; Smith, George Davey; Ring, Susan M; Grandjean, Philippe.

I: American Journal of Epidemiology, 26.06.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development

AU - Julvez, Jordi

AU - Smith, George Davey

AU - Ring, Susan M

AU - Grandjean, Philippe

PY - 2019/6/26

Y1 - 2019/6/26

N2 - Genetic predisposition may affect neurodevelopmental outcomes of prenatal methylmercury exposure. We examined suspected heterogeneities for modification of exposure-related neurodevelopment in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, 1991-2000), Bristol, United Kingdom. A subgroup (n = 1127 from a pilot study and 1045 from the present study) was identified based on the availability of the mercury concentration of cord tissue as a measure of prenatal methylmercury exposure, data on 247 single-nucleotide polymorphisms (SNPs), as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores. Log10-transformed mercury concentration was positively associated with IQ, but adjustment confounding cofactors attenuated this association. Enhanced interaction with methylmercury was replicated in the new study for the minor allele of rs1042838 (progesterone receptor) (Beta; 95% Confidence Interval) = (-11.8; -23.0, -0.6) (P-for-interaction = 0.004) and weakly for rs662 (paraoxonase 1) (-3.6; -11.4, 4.3) (P = 0.117). In the joint sample, new interacting single-nucleotide polymorphisms (SNPs) were discovered in relation to superoxide dismutase 2, ATP binding cassette subfamily A member 1, and metallothionein 1M genes. While the low-level prenatal exposure to methylmercury was not associated with child cognition, progesterone receptor rs1042838 minor alleles revealed a negative association of mercury exposure with IQ.

AB - Genetic predisposition may affect neurodevelopmental outcomes of prenatal methylmercury exposure. We examined suspected heterogeneities for modification of exposure-related neurodevelopment in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, 1991-2000), Bristol, United Kingdom. A subgroup (n = 1127 from a pilot study and 1045 from the present study) was identified based on the availability of the mercury concentration of cord tissue as a measure of prenatal methylmercury exposure, data on 247 single-nucleotide polymorphisms (SNPs), as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores. Log10-transformed mercury concentration was positively associated with IQ, but adjustment confounding cofactors attenuated this association. Enhanced interaction with methylmercury was replicated in the new study for the minor allele of rs1042838 (progesterone receptor) (Beta; 95% Confidence Interval) = (-11.8; -23.0, -0.6) (P-for-interaction = 0.004) and weakly for rs662 (paraoxonase 1) (-3.6; -11.4, 4.3) (P = 0.117). In the joint sample, new interacting single-nucleotide polymorphisms (SNPs) were discovered in relation to superoxide dismutase 2, ATP binding cassette subfamily A member 1, and metallothionein 1M genes. While the low-level prenatal exposure to methylmercury was not associated with child cognition, progesterone receptor rs1042838 minor alleles revealed a negative association of mercury exposure with IQ.

U2 - 10.1093/aje/kwz156

DO - 10.1093/aje/kwz156

M3 - Journal article

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

ER -