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2020
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Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., feb. 2020, I : Aging Cell. 19, 2, 8 s., e12907.

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DNA Methylation
Epigenomics
Sex Characteristics
Health
Denmark
Disabled Persons
Health Surveys
Population

Characteristics of Danish Centenarians’ Religious Beliefs: A Nationwide Population-Based Study

Opsahl, T., Kørup, A. K., Andersen-Ranberg, K., Christensen, K. & Hvidt, N. C., 10. jan. 2020, I : Journal of Religion and Health.

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Religion
Age Groups
Population
Denmark
Research

Clonal hematopoiesis in elderly twins: concordance, discordance and mortality

Hansen, J. W., Pedersen, D. A., Larsen, L. A., Husby, S., Clemmensen, S. B., Hjelmborg, J., Favero, F., Weischenfeldt, J., Christensen, K. & Grønbæk, K., 23. jan. 2020, I : Blood. 135, 4, s. 261-268

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Mutation
Twin Studies
Dizygotic Twins
Monozygotic Twins
Mutation Rate
Cohort Effect
Alleles
Gene-Environment Interaction
Medical Genetics
Denmark
Lewy Body Disease
Parkinson Disease
Alzheimer Disease
Mutation
DNA

Longitudinal Twin Study of Subjective Health: Differences in Genetic and Environmental Components of Variance Across Age and Sex

Finkel, D., Franz, C. E., Christensen, K., Reynolds, C. A. & Pedersen, N. L., 1. jan. 2020, I : Journals of Gerontology. Series B: Psychological Sciences & Social Sciences. 75, 1, s. 1-10

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twin studies
Twin Studies
Longitudinal Studies
Health
health

Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits

Ahrenfeldt, L. J., Christensen, K., Segal, N. L. & Hur, Y-M., jan. 2020, I : Neuroscience & Biobehavioral Reviews. 108, s. 322-340

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Twin Studies
Cognition
Fetus
Hormones

Parallel progress in perceived age and life expectancy

Steiner, U. K., Larsen, L. A. & Christensen, K., feb. 2020, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 75, 2, s. 333-339

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Life Expectancy
Health
Population
4 Downloads (Pure)

Sex differences in health and mortality by income and income changes

Ahrenfeldt, L. J., Pedersen, J. K., Thinggaard, M., Christensen, K. & Lindahl-Jacobsen, R., mar. 2020, I : Journal of Epidemiology and Community Health. 74, 3, s. 225-231 213096.

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Sex Characteristics
Health
Women's Health
Proxy
Denmark

Sources of Stability in Social and Economic Ideological Orientations: Cohort, Context, and Construct Effects

Ksiazkiewicz, A., Klemmensen, R., McGue, M., Christensen, K., Dawes, C. & Nørgaard, A. S., 2020, (Accepteret/In press) I : International Journal of Public Opinion Research.

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β-adrenoreceptors and the risk of Parkinson's disease

Hopfner, F., Höglinger, G. U., Kuhlenbäumer, G., Pottegård, A., Wod, M., Christensen, K., Tanner, C. M. & Deuschl, G., 27. jan. 2020, I : The Lancet Neurology.

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Adrenergic Receptors
Parkinson Disease
Propranolol
Albuterol
Smoking
2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Lifelines Cohort Study & V. A. Million Veteran Program, 1. jun. 2019, I : Nature Genetics. 51, 6, s. 957-972

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Kidney
Glomerular Filtration Rate
Translational Medical Research
Genome-Wide Association Study
Meta-Analysis
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A Cohort Comparison of Lifespan After Age 100 in Denmark and Sweden: Are Only the Oldest Getting Older?

Medford, A., Christensen, K., Skytthe, A. & Vaupel, J. W., apr. 2019, I : Demography. 56, 2, s. 665-677

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life-span
Denmark
Swede
Sweden
trend
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Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Mengel-From, J., Svane, A. M., Pertoldi, C., Kristensen, T. N., Loeschcke, V., Skytthe, A., Christensen, K., Lindahl-Jacobsen, R., Hjelmborg, J. & Christiansen, L., 13. nov. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 12, s. 1853-1860

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Fruit
Parents
Maternal Age
Health
Drosophila melanogaster
65 Downloads (Pure)

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 flere, Becker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J. F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L. P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J. M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., 1. dec. 2019, I : Nature Communications. 10, 1, 14 s., 3669.

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genome
Genome-Wide Association Study
genes
Meta-Analysis
Genes
77 Downloads (Pure)

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sørensen, T. I. A. & DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), aug. 2019, I : Acta Neuropathologica. 138, 2, s. 237-250

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Lewy Body Disease
Alzheimer Disease
Mutation
Neurodegenerative Diseases
Alleles
10 Downloads (Pure)

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity

Long Life Family Study, 2019, I : Metabolism: Clinical and Experimental. 94, s. 28-38

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Lung
Cognition
Fasting
Insulin
Metabolic Networks and Pathways

APOE Alleles and Extreme Human Longevity

Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., Andersen, S. L., Villa, F., Atzmon, G., Christensen, K., Arai, Y., Barzilai, N., Puca, A., Christiansen, L., Hirose, N. & Perls, T. T., 1. jan. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 1, s. 44–51

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Alleles
Population
New England
Retirement
Genetic Models

Association of low-frequency genetic variants in regulatory regions with nonsyndromic orofacial clefts

Shaffer, J. R., LeClair, J., Carlson, J. C., Feingold, E., Buxó, C. J., Christensen, K., Deleyiannis, F. W. B., Field, L. L., Hecht, J. T., Moreno, L., Orioli, I. M., Padilla, C., Vieira, A. R., Wehby, G. L., Murray, J. C., Weinberg, S. M., Marazita, M. L. & Leslie, E. J., 1. mar. 2019, I : American Journal of Medical Genetics, Part A. 179, 3, s. 467-474

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Nucleic Acid Regulatory Sequences
Cleft Palate
Cleft Lip
Alleles
Cell Line
54 Downloads (Pure)

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 flere, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3. jan. 2019, I : American Journal of Human Genetics. 104, 1, s. 112-138

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Mitochondrial Genes
Body Mass Index
Insulin
Adipocytes
Type 2 Diabetes Mellitus

A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals

Carlson, J. C., Anand, D., Butali, A., Buxo, C. J., Christensen, K., Deleyiannis, F., Hecht, J. T., Moreno, L. M., Orioli, I. M., Padilla, C., Shaffer, J. R., Vieira, A. R., Wehby, G. L., Weinberg, S. M., Murray, J. C., Beaty, T. H., Saadi, I., Lachke, S. A., Marazita, M. L., Feingold, E. & 1 flere, Leslie, E. J., sep. 2019, I : Genetic Epidemiology. 43, 6, s. 704-716

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Genome-Wide Association Study
Cleft Palate
Cleft Lip

Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers

Skytthe, A., Harris, J. R., Czene, K., Mucci, L., Adami, H-O., Christensen, K., Hjelmborg, J., Holm, N. V., Nilsen, T. S., Kaprio, J. & Pukkala, E., apr. 2019, I : Twin Research and Human Genetics. 22, 2, s. 99-107

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Confidence Intervals
Incidence
Neoplasms
Population
Registries
4 Downloads (Pure)

Declining cancer incidence at the oldest ages: Hallmark of aging or lower diagnostic activity?

Pedersen, J. K., Rosholm, J-U., Ewertz, M., Engholm, G., Lindahl-Jacobsen, R. & Christensen, K., sep. 2019, I : Journal of Geriatric Oncology. 10, 5, s. 792-798

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Incidence
Neoplasms
Skin Neoplasms
Denmark
Colon

Decomposing Sex Differences in Hospitalization-Free Years at Age 60 by Age and Cause of Admission to Hospital in Denmark, 1995–2014

Höhn, A., Oksuzyan, A., Lindahl-Jacobsen, R., Christensen, K. & Seaman, R., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Decomposing sex differences in hospitalization-free years at age 60 by age and cause of admission to hospital in Denmark, 1995 - 2014

Seaman, R., Höhn, A., Oksuzyan, A., Lindahl-Jacobsen, R. & Christensen, K., 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Deletions and loss-of-function variants in TP63 associated with orofacial clefting

Khandelwal, K. D., van den Boogaard, M-J. H., Mehrem, S. L., Gebel, J., Fagerberg, C., van Beusekom, E., van Binsbergen, E., Topaloglu, O., Steehouwer, M., Gilissen, C., Ishorst, N., van Rooij, I. A. L. M., Roeleveld, N., Christensen, K., Schoenaers, J., Bergé, S., Murray, J. C., Hens, G., Devriendt, K., Ludwig, K. U. & 6 flere, Mangold, E., Hoischen, A., Zhou, H., Dötsch, V., Carels, C. E. L. & van Bokhoven, H., jul. 2019, I : European Journal of Human Genetics. 27, 7, s. 1101-1112

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Alleles
Population Control
Penetrance
Nonsense Codon
Mutant Proteins
14 Downloads (Pure)

Diagnosing heart failure in centenarians

Rasmussen, S. H., Andersen-Ranberg, K., Dahl, J., Nybo, M., Jeune, B., Christensen, K. & Gill, S., 1. jan. 2019, I : Journal of Geriatric Cardiology. 16, 1, s. 1-11

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Brain Natriuretic Peptide
Echocardiography
Population
Denmark
Left Ventricular Function
105 Downloads (Pure)

DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

Lund, J., Li, S., Baumbach, J., Svane, A. M., Hjelmborg, J. V. B., Christiansen, L., Christensen, K., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 8. feb. 2019, I : Clinical Epigenetics. 11, 8 s., 23.

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DNA Methylation
Genome-Wide Association Study
Survival Analysis
Proportional Hazards Models
Epigenomics

Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study

LLFS Research Group, 12. dec. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences.

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Epidemiology
Spouses
Cognition
Body Mass Index
Exercise
147 Downloads (Pure)

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins

Starnawska, A., Tan, Q., Sørensen, M., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2. sep. 2019, I : Translational Psychiatry. 9, 1, 14 s., 214.

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Monozygotic Twins
Depression
DNA Methylation
Epigenomics
Flow Cytometry
111 Downloads (Pure)

Epigenome-wide association study of leukocyte telomere length

Lee, Y., Sun, D., Ori, A. P. S., Lu, A. T., Seeboth, A., Harris, S. E., Deary, I. J., Marioni, R. E., Soerensen, M., Mengel-From, J., Hjelmborg, J., Christensen, K., Wilson, J. G., Levy, D., Reiner, A. P., Chen, W., Li, S., Harris, J. R., Magnus, P., Aviv, A. & 2 flere, Jugessur, A. & Horvath, S., 26. aug. 2019, I : Aging. 11, 16, s. 5876-5894

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Telomere
Epigenomics
Women's Health
DNA Methylation
Circadian Rhythm
69 Downloads (Pure)
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Monozygotic Twins
Cell Differentiation
HLA-C Antigens
Comb and Wattles
Nucleic Acid Regulatory Sequences
14 Downloads (Pure)
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Cognition
Sex Characteristics
Linear Models
Health
Retirement

Gene-lifestyle interactions in longevity

Lindahl-Jacobsen, R. & Christensen, K., 2019, Cambridge Handbook of Successful Aging. Fernández-Ballesteros, R., Benetos, A. & Robine, J-M. (red.). New York: Cambridge University Press, s. 91-109

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition

Hearing loss, cognitive ability, and dementia in men age 19–78 years

Osler, M., Christensen, G. T., Mortensen, E. L., Christensen, K., Garde, E. & Rozing, M. P., feb. 2019, I : European Journal of Epidemiology. 34, 2, s. 125-130

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International Classification of Diseases
Registries
Depression
Physicians
Education

Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism

for the Long Life Family Study, aug. 2019, I : GeroScience. 41, 4, s. 383-393

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Lung
Fasting
Body Mass Index
Insulin
Lipids

Hver anden nyfødt bliver 100 år: Levealderen fortsætter med at stige

Christensen, K., feb. 2019, Det gode liv: Fynske opskrifter til seniorlivet. Fyens Stiftstidende

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiFormidling

Åben adgang
97 Downloads (Pure)

Independent associations of TOMM40 and APOE variants with body mass index

Long Life Family Study Research Group, 1. feb. 2019, I : Aging Cell. 18, 1, 10 s., e12869.

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Body Mass Index
Alleles
Heterozygote
Alzheimer Disease
Confidence Intervals
90 Downloads (Pure)

Is the age difference between partners related to women's earnings?

Corollo, A., Oksuzyan, A., Drefahl, S., Camarda, C. G., Juel Ahrenfeldt, L., Christensen, K. & van Raalte, A., jul. 2019, I : Demographic Research. 41, s. 425-460 15.

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age difference
income
Denmark
husband
career
21 Downloads (Pure)
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Proxy
Longitudinal Studies
Registries
Cohort Studies
Surveys and Questionnaires
84 Downloads (Pure)

Lifespans of Twins: Does Zygosity Matter?

Hjelmborg, J., Larsen, P. V., Kaprio, J., McGue, M., Scheike, T., Hougaard, P. & Christensen, K., feb. 2019, I : Genes. 10, 2, 10 s., E166.

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Dizygotic Twins
Monozygotic Twins
Twin Studies
Liver
Survival Analysis

Longitudinal Associations of Sensory and Cognitive Functioning: A Structural Equation Modeling Approach

de la Fuente, J., Hjelmborg, J., Wod, M., de la Torre-Luque, A., Caballero, F. F., Christensen, K. & Ayuso-Mateos, J. L., 4. okt. 2019, I : Journals of Gerontology. Series B: Psychological Sciences & Social Sciences. 74, 8, s. 1308-1316

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visual impairment
hearing impairment
old age
Hearing
cognition
90 Downloads (Pure)

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts

Jylhävä, J., Hjelmborg, J., Sørensen, M., Munoz, E., Tan, Q., Kuja-Halkola, R., Mengel-From, J., Christensen, K., Christiansen, L., Hägg, S., Pedersen, N. L. & Reynolds, C. A., feb. 2019, I : EBioMedicine. 40, s. 710-716

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Epigenomics
Clocks
Research
DNA Methylation
Epidemiology
56 Downloads (Pure)

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Understanding Society Scientific Group, Lifelines Cohort, COGENT-Kidney Consortium & EPIC-InterAct Consortium, apr. 2019, I : Nature Genetics. 51, 4, s. 636-648

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Smoking
Lipids
Serum
LDL Cholesterol
Meta-Analysis

Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study

Santanasto, A. J., Marron, M. M., Boudreau, R. M., Feitosa, M. F., Wojczynski, M. K., Arbeev, K. G., Thyagarajan, B., Schupf, N., Stallard, E., Sebastiani, P., Cosentino, S., Christensen, K. & Newman, A. B., 14. maj 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences.

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Survivors
Incidence
Lung
Neoplasms
Advanced Glycosylation End Product-Specific Receptor

Resting heart rate and mortality in the very old

Wod, M., Jensen, M. T., Galatius, S., Hjelmborg, J. B., Jensen, G. B. & Christensen, K., dec. 2019, I : Scandinavian Journal of Clinical & Laboratory Investigation. 79, 8, s. 566-571

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Population
Palpation
Survival Analysis
Proportional Hazards Models
Cohort Studies

Sex Differences in Comorbidity and Frailty in Europe

Ahrenfeldt, L. J., Möller, S., Thinggaard, M., Christensen, K. & Lindahl-Jacobsen, R., sep. 2019, I : International Journal of Public Health. 64, 7, s. 1025-1036

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Sex Characteristics
Comorbidity
Retirement
Health Surveys
Cross-Sectional Studies