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2019
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Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Mengel-From, J., Svane, A. M., Pertoldi, C., Kristensen, T. N., Loeschcke, V., Skytthe, A., Christensen, K., Lindahl-Jacobsen, R., Hjelmborg, J. & Christiansen, L., 13. nov. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 12, s. 1853-1860

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Fruit
Parents
Maternal Age
Health
Drosophila melanogaster
38 Downloads (Pure)

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 flere, Becker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J. F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L. P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J. M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., 1. dec. 2019, I : Nature Communications. 10, 1, 14 s., 3669.

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genome
Genome-Wide Association Study
genes
Meta-Analysis
Genes

APOE Alleles and Extreme Human Longevity

Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., Andersen, S. L., Villa, F., Atzmon, G., Christensen, K., Arai, Y., Barzilai, N., Puca, A., Christiansen, L., Hirose, N. & Perls, T. T., 1. jan. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 1, s. 44–51

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Alleles
Population
New England
Retirement
Genetic Models

DNA methylome profiling in identical twin pairs discordant for body mass index

Li, W., Zhang, D., Wang, W., Wu, Y., Mohammadnejad, A., Lund, J., Baumbach, J., Christiansen, L. & Tan, Q., dec. 2019, I : International Journal of Obesity. 43, 12, s. 2491-2499

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Monozygotic Twins
Body Mass Index
DNA Methylation
Epigenomics
Adiposity
86 Downloads (Pure)

DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

Lund, J., Li, S., Baumbach, J., Svane, A. M., Hjelmborg, J. V. B., Christiansen, L., Christensen, K., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 8. feb. 2019, I : Clinical Epigenetics. 11, 8 s., 23.

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DNA Methylation
Genome-Wide Association Study
Survival Analysis
Proportional Hazards Models
Epigenomics
108 Downloads (Pure)

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins

Starnawska, A., Tan, Q., Sørensen, M., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2. sep. 2019, I : Translational Psychiatry. 9, 1, 14 s., 214.

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Monozygotic Twins
Depression
DNA Methylation
Epigenomics
Flow Cytometry
47 Downloads (Pure)
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Monozygotic Twins
Cell Differentiation
HLA-C Antigens
Comb and Wattles
Nucleic Acid Regulatory Sequences
Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition
65 Downloads (Pure)

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts

Jylhävä, J., Hjelmborg, J., Sørensen, M., Munoz, E., Tan, Q., Kuja-Halkola, R., Mengel-From, J., Christensen, K., Christiansen, L., Hägg, S., Pedersen, N. L. & Reynolds, C. A., feb. 2019, I : EBioMedicine. 40, s. 710-716

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Epigenomics
Clocks
Research
DNA Methylation
Epidemiology
Twin Studies
2018
Body Mass Index
Monozygotic Twins
Twin Studies
Genome-Wide Association Study
Environmental Exposure

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

Mengel-From, J., Rønne, M. E., Carlsen, A. L., Skogstrand, K., Larsen, L. A., Tan, Q., Christiansen, L., Christensen, K. & Heegaard, N. H. H., 1. jan. 2018, I : Journal of Alzheimer's disease : JAD. 63, 2, s. 591-601

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Monozygotic Twins
MicroRNAs
Immunoassay
Lipoproteins
Longitudinal Studies
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Twin Studies
MicroRNAs
Cognition
Neurobiology
Monozygotic Twins
55 Downloads (Pure)

DNA methylation age and perceived age in elderly Danish twins

Debrabant, B., Sørensen, M., Christiansen, L., Tan, Q., McGue, M., Christensen, K. & Hjelmborg, J. V. B., 1. jan. 2018, I : Mechanisms of Ageing and Development. 169, s. 40-44

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DNA Methylation
Epigenomics
119 Downloads (Pure)

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins

Svane, A. M., Soerensen, M., Lund, J., Tan, Q., Jylhävä, J., Wang, Y., Pedersen, N. L., Hägg, S., Debrabant, B., Deary, I. J., Christensen, K., Christiansen, L. & Hjelmborg, J. B., 8. feb. 2018, I : Genes. 9, 2, 15 s., 78.

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DNA Methylation
Twin Studies
Monozygotic Twins
Population
93 Downloads (Pure)

Epigenetic signature of preterm birth in adult twins

Tan, Q., Li, S., Frost, M., Nygaard, M., Soerensen, M., Larsen, M., Christensen, K. & Christiansen, L., 2018, I : Clinical Epigenetics. 10, 10 s., 87.

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Premature Birth
Epigenomics
Health
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 3

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study

Xu, C., Tian, X., Sun, J., Wu, Y., Zhang, D., Pang, Z., Li, S., Petersen, I., Mengel-From, J., Christiansen, L., Christensen, K. & Tan, Q., feb. 2018, I : Geriatrics & Gerontology International. 18, 2, s. 352-359

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Twin Studies
Cognition
cognition
HDL Cholesterol
environmental factors
74 Downloads (Pure)

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., de Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 30 flere, Zabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., DeRosse, P., Dickinson, D., Djurovic, S., Christiansen, L. & Debrabant, B., 1. jul. 2018, I : Nature Genetics. 50, 7, s. 912–919

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Genome-Wide Association Study
Meta-Analysis
Mendelian Randomization Analysis
Neurobiology
Pyramidal Cells

On the power of epigenome-wide association studies using a disease-discordant twin design

Li, W., Christiansen, L., Hjelmborg, J. V. B., Baumbach, J. & Tan, Q., 1. dec. 2018, I : Bioinformatics. 34, 23, s. 4073–4078

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Diseases in Twins
Monozygotic Twins
DNA Methylation
Computational Biology
Epigenomics
105 Downloads (Pure)

Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3

Flachsbart, F., Dose, J., Gentschew, L., Geismann, C., Caliebe, A., Knecht, C., Nygaard, M., Badarinarayan, N., ElSharawy, A., May, S., Luzius, A., Torres, G. G., Jentzsch, M., Forster, M., Häsler, R., Pallauf, K., Lieb, W., Derbois, C., Galan, P., Drichel, D. & 14 flere, Arlt, A., Till, A., Krause-Kyora, B., Rimbach, G., Blanché, H., Deleuze, J-F., Christiansen, L., Christensen, K., Nothnagel, M., Rosenstiel, P., Schreiber, S., Franke, A., Sebens, S. & Nebel, A., 1. dec. 2018, I : Nature Communications. 9, 2 s., 320.

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document markup languages
HTML
genes
Genes

Surfactant protein-D, a potential mediator of inflammation in axial spondyloarthritis

Munk, H. L., Fakih, D., Christiansen, L., Tan, Q., Christensen, A. F., Ejstrup, L., Loft, A. G., Junker, K., Kyvik, K. O., Jounblat, R., Holmskov, U., Sorensen, G. L. & Junker, P., 1. okt. 2018, I : Rheumatology (Oxford, England). 57, 10, s. 1861–1865

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Pulmonary Surfactant-Associated Protein D
Molecular Weight
Serum
Single Nucleotide Polymorphism
Smoking
95 Downloads (Pure)

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions

Dato, S., Thinggaard, M. S., De Rango, F., Rose, G., Christensen, K., Christiansen, L. & Passarino, G., jun. 2018, I : Aging Cell. 17, 3, 12 s., e12755.

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Medical Genetics
Single Nucleotide Polymorphism
Metabolic Networks and Pathways
Cohort Studies
Insulin
2017

A simulation study on power of epigenome-wide association analysis using disease-discordant twin design

Li, W., Baumbach, J., Christiansen, L. & Tan, Q., 28. maj 2017.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Association reactions
Methylation
Microarrays
Computer simulation
Costs
82 Downloads (Pure)

Epigenome-wide association of DNA methylation in whole blood with bone mineral density

Morris, J. A., Tsai, P-C., Joehanes, R., Zheng, J., Trajanoska, K., Sørensen, M., Forgetta, V., Castillo-Fernandez, J. E., Frost, M., Spector, T. D., Christensen, K., Christiansen, L., Rivadeneira, F., Tobias, J. H., Evans, D. M., Kiel, D. P., Hsu, Y-H., Richards, J. B. & Bell, J. T., 2017, I : Journal of Bone and Mineral Research. 32, 8, s. 1644-1650

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DNA Methylation
Bone Density
Femur Neck
Epigenomics
Cytosine
135 Downloads (Pure)

Epigenome-wide association study of cognitive functioning in middle-aged monozygotic twins

Starnawska, A., Tan, Q., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2017, I : Frontiers in Aging Neuroscience. 9, DEC, 10 s., 413.

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Monozygotic Twins
DNA Methylation
Epigenomics
Population
Alzheimer Disease
153 Downloads (Pure)

Genetic interplay between human longevity and metabolic pathways: a large-scale eQTL study

Häsler, R., Venkatesh, G., Tan, Q., Flachsbart, F., Sinha, A., Rosenstiel, P., Lieb, W., Schreiber, S., Christensen, K., Christiansen, L. & Nebel, A., 2017, I : Aging Cell. 16, 4, s. 716–725

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Quantitative Trait Loci
Metabolic Networks and Pathways
RNA Sequence Analysis
Twin Studies
Denmark

Handling blood cell composition in epigenetic studies on ageing

Tan, Q., Heijmans, B. T., Hjelmborg, J. V. B., Thinggaard, M. S., Christensen, K. & Christiansen, L., 2017, I : International Journal of Epidemiology. 46, 5, s. 1717–1718

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Identification, replication and characterization of epigenetic remodelling in the aging genome

Li, S., Christiansen, L., Christensen, K., Kruse, T. A., Redmond, P., Marioni, R. E., Deary, L. J. & Tan, Q., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Epigenomics
CpG Islands
DNA
DNA Methylation
89 Downloads (Pure)

Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

Li, S., Christiansen, L., Christensen, K., Kruse, T. A., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 2017, I : Scientific Reports. 7, 1, 8 s., 8183.

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Epigenomics
CpG Islands
Population
DNA Methylation
88 Downloads (Pure)

Identification and characterization of two functional variants in the human longevity gene FOXO3

Flachsbart, F., Dose, J., Gentschew, L., Geismann, C., Caliebe, A., Knecht, C., Nygaard, M., Badarinarayan, N., ElSharawy, A., May, S., Luzius, A., Torres, G. G., Jentzsch, M., Forster, M., Häesler, R., Pallauf, K., Lieb, W., Derbois, C., Galan, P., Drichel, D. & 14 flere, Arlt, A., Till, A., Krause-Kyora, B., Rimbach, G., Blanché, H., Deleuze, J-F., Christiansen, L., Christensen, K., Nothnagel, M., Rosenstiel, P., Schreiber, S., Franke, A., Sebens, S. & Nebel, A., 2017, I : Nature Communications. 8, 12 s., 2063.

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Luciferases
Insulin-Like Growth Factor I
genes
Assays
Transcription Factors
88 Downloads (Pure)

Investigation of the 5q33.3 longevity locus and age-related phenotypes

Nygaard, M., Thinggaard, M., Christensen, K. & Christiansen, L., 2017, I : Aging. 9, 1, s. 247-255

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Alleles
Meta-Analysis
Health
90 Downloads (Pure)

Lung function discordance in monozygotic twins and associated differences in blood DNA methylation

Bolund, A. C. S., Starnawska, A., Miller, M. R., Schlünssen, V., Backer, V., Børglum, A. D., Christensen, K., Tan, Q., Christiansen, L. & Sigsgaard, T., 2017, I : Clinical Epigenetics (Print). 9, 13 s., 132.

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Monozygotic Twins
DNA Methylation
Lung
Epigenomics
Forced Expiratory Volume
126 Downloads (Pure)

Telomeres and the natural lifespan limit in humans

Steenstrup, T., Kark, J. D., Verhulst, S., Thinggaard, M., Hjelmborg, J. V. B., Dalgård, C., Kyvik, K. O., Christiansen, L., Mangino, M., Spector, T. D., Petersen, I., Kimura, M., Benetos, A., Labat, C., Sinnreich, R., Hwang, S-J., Levy, D., Hunt, S. C., Fitzpatrick, A. L., Chen, W. & 9 flere, Berenson, G. S., Barbieri, M., Paolisso, G., Gadalla, S. M., Savage, S. A., Christensen, K., Yashin, A. I., Arbeev, K. G. & Aviv, A., 2017, I : Aging. 9, 4, s. 1130-1142

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Telomere
Life Expectancy
2016

Blood DNA methylation age is not associated with cognitive functioning in middle-aged monozygotic twins

Starnawska, A., Tan, Q., Lenart, A., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2016, I : Neurobiology of Aging. 50, s. 60-63

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Monozygotic Twins
DNA Methylation
Twin Studies
Epigenomics
Cognition
95 Downloads (Pure)

Change in Depression Symptomatology and Cognitive Function in Twins: A 10-Year Follow-Up Study

Petersen, I., McGue, M., Tan, Q., Christensen, K. & Christiansen, L., apr. 2016, I : Twin Research and Human Genetics. 19, 2, s. 104-111

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antineoplaston A10
Cognition
Depression
Affective Symptoms
Twin Studies
90 Downloads (Pure)

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

Nygaard, M., Debrabant, B., Tan, Q., Deelen, J., Andersen-Ranberg, K., de Craen, A. J. M., Beekman, M., Jeune, B., Slagboom, P. E., Christensen, K. & Christiansen, L., feb. 2016, I : Aging Cell. 15, 1, s. 49-55

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Human Genome
Population
165 Downloads (Pure)

Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity

Trier Møller, F., Almind Knudsen, L., Harbord, M., Satsangi, J., Gordon, H., Christiansen, L., Christensen, K., Jess, T. & Andersen, V., jun. 2016, I : World Journal of Gastroenterology. 22, 21, s. 5050-9

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Inflammatory Bowel Diseases
Computational Biology
Centrifugation
Registries
138 Downloads (Pure)

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study

Svendsen, A. J., Gervin, K., Lyle, R., Christiansen, L., Kyvik, K., Junker, P., Nielsen, C., Houen, G. & Tan, Q., 2016, I : Frontiers in Immunology. 7, 10 s., 510.

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Monozygotic Twins
DNA
Smoking
Antirheumatic Agents
DNA Methylation

Differentially Methylated Genomic Regions in Birth-Weight Discordant Twin Pairs

Chen, M., Baumbach, J., Vandin, F., Röttger, R., Vieira Barbosa, E. G., Dong, M., Nielsen, M. F. M., Christiansen, L. & Tan, Q., 2016, I : Annals of Human Genetics. 80, 2, s. 81-87

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DNA Methylation
Epigenomics
Monozygotic Twins
Chromosomes, Human, Pair 1
Health
127 Downloads (Pure)

DNA methylation age is associated with mortality in a longitudinal Danish twin study

Christiansen, L., Lenart, A., Tan, Q., Vaupel, J. W., Aviv, A., McGue, M. & Christensen, K., 2016, I : Aging Cell. 15, 1, s. 149-54

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Twin Studies
DNA Methylation
Survival Analysis
Epigenomics
Longitudinal Studies

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort

Tan, Q., Heijmans, B. T., Hjelmborg, J. V. B., Sørensen, M., Christensen, K. & Christiansen, L., 2016, I : International Journal of Epidemiology. 45, 4, s. 1146-1158

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Cytosine
Guanine
Epigenomics
DNA Methylation
Survival Analysis

G×E Interaction Influences Trajectories of Hand Grip Strength

Petersen, I., Pedersen, N. L., Rantanen, T., Kremen, W. S., Johnson, W., Panizzon, M. S., Christiansen, L., Franz, C. E., McGue, M., Christensen, K., Hamdi, N. R., Krueger, R. F. & Reynolds, C., jan. 2016, I : Behavior Genetics. 46, s. 20-30

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trajectories
growth curve
hands
genotype-environment interaction
trajectory

Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?

Reynolds, C. A., Gatz, M., Christensen, K., Christiansen, L., Dahl Aslan, A. K., Kaprio, J., Korhonen, T., Kremen, W. S., Krueger, R., McGue, M., Neiderhiser, J. M., Pedersen, N. L. & IGEMS consortium, jan. 2016, I : Behavior Genetics. 46, 1, s. 4-19

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adulthood
body mass index
Body Mass Index
Depression
body mass

Genetic Influence on the Peripheral Blood CD4+ T-cell Differentiation Status in CMV Infection

Goldeck, D., Larsen, L. A., Christiansen, L., Christensen, K., Hamprecht, K., Pawelec, G. & Derhovanessian, E., 2016, I : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 71, 12, s. 1537-1543

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Cytomegalovirus Infections
Cell Differentiation
Cytomegalovirus
Viruses
Herpesviridae
97 Downloads (Pure)
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Cognition
Haplotypes
Heterozygote
Central Nervous System
Cognitive Dysfunction
138 Downloads (Pure)

Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots

Staunstrup, N. H., Starnawska, A., Nyegaard, M., Christiansen, L., Nielsen, A. L., Børglum, A. & Mors, O., 2016, I : Clinical Epigenetics (Print). 8, 81.

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DNA Methylation
DNA
Neonatal Screening
Environmental Exposure
Epigenomics
84 Downloads (Pure)

Immunochip analysis identifies association of the RAD50/IL13 region with human longevity

Flachsbart, F., Ellinghaus, D., Gentschew, L., Heinsen, F-A., Caliebe, A., Christiansen, L., Nygaard, M., Christensen, K., Blanché, H., Deleuze, J-F., Derbois, C., Galan, P., Büning, C., Brand, S., Peters, A., Strauch, K., Müller-Nurasyid, M., Hoffmann, P., Nöthen, M. M., Lieb, W. & 3 flere, Franke, A., Schreiber, S. & Nebel, A., jun. 2016, I : Aging Cell. 15, 3, s. 585-588

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Interleukin-13
Single Nucleotide Polymorphism
Meta-Analysis
Denmark
France
Polymorphism
Nucleotides
Genes
Aging of materials
Single Nucleotide Polymorphism