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2019
52 Downloads (Pure)

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, I : Theranostics. 9, 9, s. 2662-2677

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Nucleic Acids
Medicine
Precision Medicine
Confocal Microscopy
Hepatocytes
128 Downloads (Pure)

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28. jan. 2019, I : Journal of Controlled Release. 294, s. 247-258

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Hydrogel
Hyaluronic Acid
Chondrocytes
Joints
Disintegrins

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14. mar. 2019, I : Journal of Medicinal Chemistry. 62, 5, s. 2499-2507

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Nucleic Acids
Nucleotide Aptamers
RNA
Freezing
Serum
67 Downloads (Pure)

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9. apr. 2019, I : Scientific Reports. 9, 11 s., 5836.

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Fibroblast Growth Factor 7
MicroRNAs
Skin
Wounds and Injuries
Diabetic Foot
16 Downloads (Pure)

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

Gasparri, F., Wengel, J., Grutter, T. & Pless, S. A., 1. jul. 2019, I : Journal of General Physiology. 151, 7, s. 898-911 14 s.

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Ligands
Site-Directed Mutagenesis
Amides
Cations
Esters

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

Abdelrahman, A., Gouda, A. S., Jørgensen, P. T. & Wengel, J., 1. nov. 2019, I : Nucleosides, Nucleotides and Nucleic Acids.

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Oligonucleotides
Nucleic Acids
Monomers
Molecular modeling
Fluorescence spectroscopy
61 Downloads (Pure)

Oligonucleotide binding to non-B-DNA in MYC

Umek, T., Sollander, K., Bergquist, H., Wengel, J., Lundin, K. E., Edvard Smith, C. I. & Zain, R., 12. mar. 2019, I : Molecules. 24, 5, 11 s., 1000.

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oligonucleotides
Oligonucleotides
genes
strands
Genes
16 Downloads (Pure)

Synthetic, structural, and anticancer activity evaluation studies on novel pyrazolylnucleosides

Yadav, Y., Sharma, D., Kaushik, K., Kumar, V., Jha, A., Prasad, A. K., Len, C., Malhotra, S. V., Wengel, J. & Parmar, V. S., 30. okt. 2019, I : Molecules. 24, 21, 16 s., 3922.

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cultured cells
Cells
Cell Line
evaluation
cancer
79 Downloads (Pure)

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Xu, Y., Gissberg, O., Pabon-Martinez, Y. V., Wengel, J., Lundin, K. E., Smith, C. I. E., Zain, R., Nilsson, L. & Villa, A., 2019, I : PLOS ONE. 14, 2, 14 s., e0211651.

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oligonucleotides
Oligonucleotides
nucleic acids
DNA
molecular dynamics
2018
202 Downloads (Pure)

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Moreno, P. M. D., Ferreira, A. R., Salvador, D., Rodrigues, M. T., Torrado, M., Carvalho, E. D., Tedebark, U., Sousa, M. M., Amaral, I. F., Wengel, J. & Pêgo, A. P., 2018, I : Molecular Therapy - Nucleic Acids. 11, s. 393-406

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Hydrogel
Spinal Ganglia
Nucleic Acids
Cell Survival
Down-Regulation
75 Downloads (Pure)

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J. & Xodo, L. E., 2018, I : RNA Biology. 15, 10, s. 1273-1285

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MicroRNAs
Pancreatic Neoplasms
Cell-Penetrating Peptides
Nucleic Acids
Down-Regulation
49 Downloads (Pure)

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Ejlersen, M., Lou, C., Sanghvi, Y. S., Tor, Y. & Wengel, J., 12. jul. 2018, I : Chemical Communications. 54, 57, s. 8003-8006

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Oligonucleotides
Oligodeoxyribonucleotides
Boronic Acids
Monomers
Acids
73 Downloads (Pure)

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

Vejlegaard, K., Wegeberg, C., McKee, V. & Wengel, J., 2018, I : Organic & Biomolecular Chemistry. 16, 8, s. 1312-1321

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Oligonucleotides
Bearings (structural)
Derivatives
Ribonucleosides
Complementary RNA
44 Downloads (Pure)

Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity

Cai, Y., Makarova, A-M., Wengel, J. & Howard, K. A., 2018, I : Journal of Gene Medicine. 20, 7-8, s. 1-6

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Caco-2 Cells
Albumins
erbB-1 Genes
Flow Cytometry
Fatty Acids
82 Downloads (Pure)

Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA

Ejlersen, M., Christensen, N. J., Sørensen, K. K., Jensen, K. J., Wengel, J. & Lou, C., 2018, I : Bioconjugate Chemistry. 29, 4, s. 1025–1029

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AT-Hook Motifs
Hooks
Peptides
DNA
Oligonucleotides
86 Downloads (Pure)

Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides

Lima, J. F., Carvalho, J., Pinto-Ribeiro, I., Almeida, C., Wengel, J., Cerqueira, L., Figueiredo, C., Oliveira, C. & Azevedo, N. F., 7. jun. 2018, I : BMC Molecular Biology. 19, 13 s., 6.

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MicroRNAs
Cell Movement
Culture Media
Up-Regulation
80 Downloads (Pure)

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

Kotkowiak, W., Lisowiec-Wachnicka, J., Grynda, J., Kierzek, R., Wengel, J. & Pasternak, A., 2018, I : Molecular Therapy - Nucleic Acids. 10, s. 304-316

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Nucleic Acids
Fibrinolysis
HeLa Cells
Cell Movement
Cell Proliferation
64 Downloads (Pure)

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens

Le, B. T., Hughes, Q., Rakesh, S., Baker, R., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2018, I : RSC Advances. 8, 57, s. 32770-32774

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Human Platelet Antigens
Nucleic acids
Antigens
Nucleotides
Platelets
2017

3'-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes

Ejlersen, M., Langkjær, N. & Wengel, J., 2017, I : Organic & Biomolecular Chemistry. 15, 9, s. 2073-2085

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Nucleic Acids
Oligonucleotides
Stabilization
Fluorescence
DNA
96 Downloads (Pure)

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

Cai, Y., López-Ruiz, E., Wengel, J., Creemers, L. B. & Howard, K. A., 2017, I : Journal of controlled release : official journal of the Controlled Release Society. 253, s. 153-159

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Hydrogel
Hyaluronic Acid
Chondrocytes
Patient Participation
Schiff Bases
114 Downloads (Pure)

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J. S., Sohn, E., Bienk, K., Schaffert, D., Sørensen, E. S., Wengel, J., Dupont, D. M. & Howard, K. A., 2017, I : Molecular Therapy - Nucleic Acids. 9, s. 284-293

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Life Expectancy
Half-Life
Albumins
Factor IXa
Pharmaceutical Preparations
270 Downloads (Pure)

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Zaghloul, E. M., Gissberg, O., Moreno, P. M. D., Siggens, L., Hällbrink, M., Jørgensen, A. S., Ekwall, K., Zain, R., Wengel, J., Lundin, K. E. & Smith, C. I. E., 2017, I : Nucleic Acids Research. 45, 9, s. 5153-5169

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Huntington Disease
Trinucleotide Repeat Expansion
Gene Knockdown Techniques
Messenger RNA
Proteins
85 Downloads (Pure)

Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule

Aaldering, L. J., Poongavanam, V., Langkjær, N., Murugan, N. A., Jørgensen, P. T., Wengel, J. & Veedu, R. N., 2017, I : ChemBioChem. 18, 8, s. 755–763

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Carbon
Molecules
Thrombin
Nucleic Acids
Circular dichroism spectroscopy
85 Downloads (Pure)

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J. S., Wengel, J., Kjems, J. & Howard, K. A., 2017, I : Molecular Therapy. 25, 7, s. 1710-1717

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Fatty Acids
Pharmacokinetics
Albumins
Palmitic Acid
Myristic Acid
87 Downloads (Pure)

Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

Lou, C., Christensen, N. J., Martos-Maldonado, M. C., Midtgaard, S. R., Ejlersen, M., Thulstrup, P. W., Sørensen, K. K., Jensen, K. J. & Wengel, J., 2017, I : Chemistry: A European Journal. 23, 39, s. 9297–9305

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Oligonucleotides
Peptides
Topology
Circular dichroism spectroscopy
Denaturation
148 Downloads (Pure)

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

Pabon-Martinez, Y. V., Xu, Y., Villa, A., Lundin, K. E., Geny, S., Nguyen, C-H., Pedersen, E. B., Jørgensen, P. T., Wengel, J., Nilsson, L., Smith, C. I. E. & Zain, R., 2017, I : Scientific Reports. 7, 1, 16 s., 11043.

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DNA
Electrophoretic Mobility Shift Assay
Molecular Dynamics Simulation
Nucleic Acids
triplex DNA
177 Downloads (Pure)

Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers

Kristensen, K. V., Paul, S., Kosbar, T., Wengel, J. & Caruthers, M. H., 2017, I : Bioorganic & Medicinal Chemistry Letters. 27, 14, s. 3173–3176

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Morpholinos
Oligodeoxyribonucleotides
Nucleotides
Monomers
Complementary RNA

Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA

Lou, C., Samuelsen, S. V., Christensen, N. J., Vester, B. & Wengel, J., 2017, I : Bioconjugate Chemistry. 28, 4, s. 1214-1220

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Complementary RNA
Oligonucleotides
Nucleotides
RNA
DNA
210 Downloads (Pure)

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

Hartono, Y. D., Pabon-Martinez, Y. V., Uyar, A., Wengel, J., Lundin, K. E., Zain, R., Smith, C. I. E., Nilsson, L. & Villa, A., 2017, I : ACS Omega. 2, 5, s. 2165-2177 13 s.

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Cytidine
Oligonucleotides
Thymine
DNA sequences
Nucleic acids

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding

Schmøkel, J., Voldum, A., Tsakiridou, G., Kuhlmann, M., Cameron, J., Sørensen, E. S., Wengel, J. & Howard, K. A., 2017, I : Nanotechnology. 28, 20, 9 s., 204004.

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Pharmacokinetics
Nucleic acids
High performance liquid chromatography
Cyclohexane
Electrophoresis
104 Downloads (Pure)

Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units

Kumar, R., Ries, A. & Wengel, J., 2017, I : Molecules. 22, 5, 13 s., 852.

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galactose
oligonucleotides
Galactose
Oligonucleotides
complementary DNA
2016

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing

Bienk, K., Hvam, M. L., Pakula, M. M., Dagnæs-Hansen, F., Wengel, J., Malle, B. M., Kragh-Hansen, U., Cameron, J., Bukrinski, J. T. & Howard, K. A., 2016, I : Journal of Controlled Release. 232, s. 143-151

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RNA Interference
Small Interfering RNA
Albumins
Pharmacokinetics
Half-Life

Application of locked nucleic acid-based probes in fluorescence in situ hybridization

Fontenete, S., Carvalho, D. R., Guimarães, N., Madureira, P., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2016, I : Applied Microbiology and Biotechnology. 100, 13, s. 5897-5906

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RNA
Microbiology
Helicobacter pylori
Nucleic Acids
Freezing

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs

Gissberg, O., Zaghloul, E. M., Lundin, K. E., Nguyen, C-H., Landras-Guetta, C., Wengel, J., Zain, R. & Smith, C. I. E., 2016, I : Nucleic Acid Therapeutics. 26, 3, s. 183-189

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Oligonucleotides
Plasticity
Cell Survival
Cells
ellipticine

Evaluation of nucleolin and somatostatin receptor targeting for therapeutic delivery to lung cancer stem cells

Hansen, P. L., Holmboe, S., Olsen, B. B., Thisgaard, H., Christiansen, H., Schmidt, S., Block, I., Müller, C., Langkjær, N., Jørgensen, P. T., Vogel, S., Wengel, J., Høilund-Carlsen, P. F. & Mollenhauer, J., 27. jun. 2016.

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223 Downloads (Pure)

Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model

Fontenete, S., Leite, M., Cappoen, D., Santos, R., Ginneken, C. V., Figueiredo, C., Wengel, J., Cos, P. & Azevedo, N. F., 2016, I : P L o S One. 11, 2, 18 s., e0148353.

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Helicobacter pylori
Helicobacter Infections
probes (equipment)
hybridization
Fluorescence
257 Downloads (Pure)

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Geny, S., Moreno, P. M. D., Krzywkowski, T., Gissberg, O., Andersen, N. K., Isse, A. J., El-Madani, A. M., Lou, C., Pabon, Y. V., Anderson, B. A., Zaghloul, E. M., Zain, R., Hrdlicka, P. J., Jørgensen, P. T., Nilsson, M., Lundin, K. E., Pedersen, E. B., Wengel, J. & Smith, C. I. E., 18. mar. 2016, I : Nucleic Acids Research. 44, 5, s. 2007-2019

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DNA
Superhelical DNA
121 Downloads (Pure)

Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J., 2016, I : Nature Communications. 7, s. 1-9 12294.

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oligonucleotides
Oligonucleotides
helices
peptides
assembly

Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models

Fontenete, S., Guimarães, N., Wengel, J. & Azevedo, N. F., 2016, I : Critical Reviews in Biotechnology. 36, 3, s. 566-577

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Freezing
Nucleic Acids
DNA

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2'-Amino-LNA Monomers

Ries, A., Kumar, R., Lou, C., Kosbar, T., Vengut-Climent, E., Jørgensen, P. T., Morales, J. C. & Wengel, J., 13. okt. 2016, I : The Journal of Organic Chemistry. 81, 22, s. 10845-10856

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Galactose
Oligonucleotides
Monomers
Derivatives
DNA
2015

Detection and discrimination of biofilm populations using locked nucleic acid/2'-O-methyl-RNA fluorescence in situ hybridization (LNA/2'OMe-FISH)

Azevedo, A. S., Almeida, C., Pereira, B., Madureira, P., Wengel, J. & Azevedo, N. F., 2015, I : Biochemical Engineering Journal. 104, 15 December, s. 64-73 10 s.

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Biofilms
Fluorescence
RNA
Oligonucleotide Probes
Catheters
95 Downloads (Pure)

Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori

Santos, R. S., Dakwar, G. R., Xiong, R., Forier, K., Remaut, K., Stremersch, S., Guimarães, N., Fontenete, S., Wengel, J., Leite, M., Figueiredo, C., De Smedt, S. C., Braeckmans, K. & Azevedo, N. F., 10. dec. 2015, I : Molecular Therapy - Nucleic Acids. 4, s. e269 9 s.

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Mucus
Helicobacter pylori
RNA
Nucleic Acids
Population

Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids

Fontenete, S., Joana, B., Pedro, M., Céu, F., Wengel, J. & Filipe, A. N., maj 2015, I : Applied Microbiology and Biotechnology. 99, 9, s. 3961-3969

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Nucleic Acids
Fluorescent Dyes
RNA
Peptide Nucleic Acids
Helicobacter pylori
101 Downloads (Pure)

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

Opazo, F., Eiden, L., Hansen, L., Rohrbach, F., Wengel, J., Kjems, J. & Mayer, G., 2015, I : Molecular Therapy - Nucleic Acids. 4, 10 s., e251.

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Nucleotide Aptamers
Quantum Dots
Equipment and Supplies
Clathrin
Endocytosis
137 Downloads (Pure)

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance

Lou, C., Vester, B. & Wengel, J., 9. feb. 2015, I : Chemical Communications. 51, 19, s. 4024-4027

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Oligonucleotides
Monomers
Complementary RNA
RNA
Nucleosides
155 Downloads (Pure)

Selection of LNA-containing DNA aptamers against recombinant human CD73

Elle, I. C., Karlsen, K. K., Terp, M. G., Larsen, N., Nielsen, R., Derbyshire, N., Mandrup, S., Ditzel, H. J. & Wengel, J., 21. apr. 2015, I : Molecular BioSystems. 11, 5, s. 1260-1270

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Nucleotide Aptamers
Surface Plasmon Resonance
Computational Biology
Libraries
Cluster Analysis

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

Edwards, S. L., Poongavanam, V., R Kanwar, J., Roy, K., M. Hillman, K., Prasad, N., Leth-Larsen, R., Petersen, M., Marusic, M., Plavec, J., Wengel, J. & Veedu, R. N., 7. maj 2015, I : Chemical Communications. 51, 46, s. 9499-9502

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Oligonucleotides
Nucleic acids
Vascular Endothelial Growth Factor A
Nucleotide Aptamers
Vascular Endothelial Growth Factor Receptor
289 Downloads (Pure)

Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes

Fontenete, S., Leite, M., Guimarães, N., Madureira, P., Ferreira, R. M., Figueiredo, C., Wengel, J. & Azevedo, N. F., 2015, I : PLOS ONE. 10, 4, s. e0125494 22 s.

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Nucleic Acid Probes
pylorus
gastric mucosa
Pylorus
fluorescence in situ hybridization

Watson-Crick hydrogen bonding of unlocked nucleic acids

Langkjær, N., Wengel, J. & Pasternak, A., 15. nov. 2015, I : Bioorganic & Medicinal Chemistry Letters. 25, 22, s. 5064-6 3 s.

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Hydrogen Bonding
Oligonucleotides
Nucleic Acids
Hydrogen bonds
Hypoxanthine