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2019
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A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. nov. 2019, I : Cell Death & Disease. 10, 11, 12 s., 841.

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Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3

Block, I., Müller, C., Sdogati, D., Pedersen, H., List, M., Jaskot, A. M., Syse, S. D., Lund Hansen, P., Schmidt, S., Christiansen, H., Casella, C., Bering Olsen, S., Blomstrøm, M. M., Riedel, A., Thomassen, M., Kruse, T. A., Karlskov Hansen, S. W., Kioschis, P. & Mollenhauer, J., 6. jun. 2019, I : Oncogene. 38, 23, s. 4560-4573

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Properdin
Up-Regulation
Growth
Neoplasms
Mutation

Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia

Garabet, L., Ghanima, W., Monceyron Jonassen, C., Skov, V., Holst, R., Mowinckel, M-C., Hans, C. H., Torben, A. K., Thomassen, M., Liebman, H., Bussel, J. B. & Sandset, P. M., 17. feb. 2019, I : Platelets. 30, 2, s. 206-212

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Thrombopoietin Receptors
P-Selectin
Idiopathic Thrombocytopenic Purpura
Plasminogen Activator Inhibitor 1
Platelet Count

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

Jacobsen, V. M., Li, S., Wang, A., Zhu, D., Liu, M., Thomassen, M., Kruse, T. A. & Tan, Q., 3. aug. 2019, I : Gynecological Endocrinology. 35, 8, s. 691-694

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Polycystic Ovary Syndrome
Epigenomics
DNA Methylation
HLA-G Antigens
Chromosomes, Human, Pair 19

Evaluation of tumor-infiltrating lymphocytes and association with prognosis in BRCA-mutated breast cancer

Sønderstrup, I. M. H., Jensen, M. B., Ejlertsen, B., Eriksen, J. O., Gerdes, A. M., Kruse, T. A., Larsen, M. J., Thomassen, M. & Laenkholm, A. V., 4. mar. 2019, I : Acta Oncologica. 58, 3, s. 363-370

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Tumor-Infiltrating Lymphocytes
Mutation
Germ-Line Mutation
Risk Reduction Behavior
Paraffin
35 Downloads (Pure)

FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: Today, Tomorrow, and Beyond

Centre for Personalized Response Monitoring in Oncology (PREMIO), 15. aug. 2019, I : Cancers . 11, 8, 13 s., 1190.

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Neoplasms
Disease-Free Survival
Prospective Studies
Guidelines
Response Evaluation Criteria in Solid Tumors
56 Downloads (Pure)

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

EMBRACE Collaborators, 15. apr. 2019, I : Nature Communications. 10, 18 s., 1741.

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genome
Genome-Wide Association Study
loci
Transcriptome
breast

Genomisk medicin og kunstig intelligens

Kruse, T. A., Larsen, M. J., Tan, Q., Andersen, L. & Thomassen, M., 1. apr. 2019, I : Ugeskrift for Laeger. 181, 7A, V02190085.

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Medicine
Datasets
Clinical Decision-Making
Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

Thomassen, M. & GEMO Study Collaborators, 1. apr. 2019, I : National Cancer Institute. Journal (Print). 111, 4, s. 350-364

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Random Allocation
Body Mass Index
Mutation
Confidence Intervals
Proportional Hazards Models

IMPACT OF SMOKING ON JAK2V617F ALLELE BURDEN AMONG PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS TREATED WITH PEGYLATED INTERFERON ALPHA-2 OR HYDROXYUREA IN THE DALIAH TRIAL

Andersen Patel, D., Knudsen, T. A., Lund Hansen, D., Ocias, L. F., Weiss Bjerrum, O., Brabrand, M., Ellervik, C., el Fassi, D., Frederiksen, M., Kjær, L., Kielsgaard Kristensen, T., Kruse, T., Mourits-Andersen, H. T., Møller, P., Overgaard, U. M., Severinsen, M. T., Skov, V., Lindholm Sørensen, A., Jesper, S., Starklint, J. & 4 flere, de Stricker, K., Thomassen, M., Larsen, T. S. & Hasselbalch, H. C., jun. 2019, I : HemaSphere. 2019, PB2210.

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Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Lautrup, C. K. & kConFab Investigators, sep. 2019, I : Human Mutation. 40, 9, s. 1557-1578

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Virulence
Computational Biology
Pathology
Messenger RNA
Research

Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

kConFab Investigators, 19. jun. 2019, I : British Journal of Cancer. 121, 2, s. 180–192

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Random Allocation
Ovarian Neoplasms
Body Mass Index
Mutation
Confidence Intervals
88 Downloads (Pure)

MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification

Eskildsen, T. V., Ayoubi, S., Thomassen, M., Burton, M., Mandegar, M. A., Conklin, B. R., Jensen, C. H., Andersen, D. C. & Sheikh, S. P., jan. 2019, I : Developmental Biology. 445, 1, s. 1-7

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Primitive Streak
Cell Differentiation
Mesoderm
Messenger RNA

Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease

The Danish IBD Genetics Working Group, apr. 2019, I : Alimentary Pharmacology and Therapeutics. 49, 7, s. 890-903

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Interleukin-18
Inflammatory Bowel Diseases
Ulcerative Colitis
Tumor Necrosis Factor-alpha
Crohn Disease
93 Downloads (Pure)

Shared heritability and functional enrichment across six solid cancers

Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C. & 313 flere, Antonenkova, N. N., Arnold, S. M., Aronson, K. J., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Batra, J., Beckmann, M. W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S. I., Bickeböller, H., Bien, S. A., Blomqvist, C., Boccia, S., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Brauch, H., Brenner, H., Brenton, J. D., Brook, M. N., Brunet, J., Brunnström, H., Buchanan, D. D., Burwinkel, B., Butzow, R., Cadoni, G., Caldés, T., Caligo, M. A., Campbell, I., Campbell, P. T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A. L., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chen, C., Christiani, D. C., Claes, K. B. M., Claessens, F., Clements, J., Collée, J. M., Correa, M. C., Couch, F. J., Cox, A., Cunningham, J. M., Cybulski, C., Czene, K., Daly, M. B., deFazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J. L., Dörk, T., Duell, E. J., Dunning, A. M., Dwek, M., Eccles, D. M., Edlund, C. K., Edwards, D. R. V., Ellberg, C., Evans, D. G., Fasching, P. A., Ferris, R. L., Liloglou, T., Figueiredo, J. C., Fletcher, O., Fortner, R. T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S. J., Ganz, P. A., Garber, J., García-Sáenz, J. A., Gayther, S. A., Giles, G. G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., Goode, E. L., Goodman, M. T., Goodman, G., Grankvist, K., Greene, M. H., Gronberg, H., Gronwald, J., Guénel, P., Håkansson, N., Hall, P., Hamann, U., Hamdy, F. C., Hamilton, R. J., Hampe, J., Haugen, A., Heitz, F., Herrero, R., Hillemanns, P., Hoffmeister, M., Høgdall, E., Hong, Y-C., Hopper, J. L., Houlston, R., Hulick, P. J., Hunter, D. J., Huntsman, D. G., Idos, G., Imyanitov, E. N., Ingles, S. A., Isaacs, C., Jakubowska, A., James, P., Jenkins, M. A., Johansson, M., Johansson, M., John, E. M., Joshi, A. D., Kaneva, R., Karlan, B. Y., Kelemen, L. E., Kühl, T., Khaw, K-T., Khusnutdinova, E., Kibel, A. S., Kiemeney, L. A., Kim, J., Kjaer, S. K., Knight, J. A., Kogevinas, M., Kote-Jarai, Z., Koutros, S., Kristensen, V. N., Kupryjanczyk, J., Lacko, M., Lam, S., Lambrechts, D., Landi, M. T., Lazarus, P., Le, N. D., Lee, E., Lejbkowicz, F., Lenz, H-J., Leslie, G., Lessel, D., Lester, J., Levine, D. A., Li, L., Li, C. I., Lindblom, A., Lindor, N. M., Liu, G., Loupakis, F., Lubiński, J., Maehle, L., Maier, C., Mannermaa, A., Marchand, L. L., Margolin, S., May, T., McGuffog, L., Meindl, A., Middha, P., Miller, A., Milne, R. L., MacInnis, R. J., Modugno, F., Montagna, M., Moreno, V., Moysich, K. B., Mucci, L., Muir, K., Mulligan, A. M., Nathanson, K. L., Neal, D. E., Ness, A. R., Neuhausen, S. L., Nevanlinna, H., Newcomb, P. A., Newcomb, L. F., Nielsen, F. C., Nikitina-Zake, L., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olama, A. A. A., Olopade, O. I., Olshan, A. F., Olsson, H., Osorio, A., Pandha, H., Park, J. Y., Pashayan, N., Parsons, M. T., Pejovic, T., Penney, K. L., Peters, W. H. M., Phelan, C. M., Phipps, A. I., Plaseska-Karanfilska, D., Pring, M., Prokofyeva, D., Radice, P., Stefansson, K., Ramus, S. J., Raskin, L., Rennert, G., Rennert, H. S., van Rensburg, E. J., Riggan, M. J., Risch, H. A., Risch, A., Roobol, M. J., Rosenstein, B. S., Rossing, M. A., De Ruyck, K., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schabath, M. B., Schleutker, J., Schmidt, M. K., Setiawan, V. W., Shen, H., Siegel, E. M., Sieh, W., Singer, C. F., Slattery, M. L., Sorensen, K. D., Southey, M. C., Spurdle, A. B., Stanford, J. L., Stevens, V. L., Stintzing, S., Stone, J., Sundfeldt, K., Sutphen, R., Swerdlow, A. J., Tajara, E. H., Tangen, C. M., Tardon, A., Taylor, J. A., Teare, M. D., Teixeira, M. R., Terry, M. B., Terry, K. L., Thibodeau, S. N., Thomassen, M., Bjørge, L., Tischkowitz, M., Toland, A. E., Torres, D., Townsend, P. A., Travis, R. C., Tung, N., Tworoger, S. S., Ulrich, C. M., Usmani, N., Vachon, C. M., Van Nieuwenhuysen, E., Vega, A., Aguado-Barrera, M. E., Wang, Q., Webb, P. M., Weinberg, C. R., Weinstein, S., Weissler, M. C., Weitzel, J. N., West, C. M. L., White, E., Whittemore, A. S., Wichmann, H-E., Wiklund, F., Winqvist, R., Wolk, A., Woll, P., Woods, M., Wu, A. H., Wu, X., Yannoukakos, D., Zheng, W., Zienolddiny, S., Ziogas, A., Zorn, K. K., Lane, J. M., Saxena, R., Thomas, D., Hung, R. J., Diergaarde, B., McKay, J., Peters, U., Hsu, L., García-Closas, M., Eeles, R. A., Chenevix-Trench, G., Brennan, P. J., Haiman, C. A., Simard, J., Easton, D. F., Gruber, S. B., Pharoah, P. D. P., Price, A. L., Pasaniuc, B., Amos, C. I., Kraft, P. & Lindström, S., 25. jan. 2019, I : Nature Communications. 10, 1, s. 1-23 431.

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cancer
Nucleic Acid Regulatory Sequences
Tumors
Neoplasms
Genes
18 Downloads (Pure)

Subtypes in BRCA-mutated breast cancer

Sønderstrup, I., Jensen, M. B., Ejlertsen, B., Eriksen, J. O., Gerdes, A. M., Kruse, T. A., Larsen, M. J., Thomassen, M. & Lænkholm, A. V., 1. feb. 2019, I : Human Pathology. 84, s. 192-201

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Germ Cells
Germ-Line Mutation
Neoplasms
Hormones
Breast Cancer 3
8 Downloads (Pure)

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Bojesen, S. E., Flyger, H., Nielsen, F. C., Rossing, M. & ABCTB Investigators, nov. 2019, I : npj Breast Cancer. 5, 14 s., 38.

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Chromosome Fragility
BRCA2 Gene
BRCA1 Gene
Cell Survival
Fibroblasts

The Optimal Sequencing Depth of Tumor Biopsies for Identifying Clonal Cell Populations

Tabatabaeifar, S., Larsen, M. J., Thomassen, M., Larsen, S. R., Kruse, T. A. & Sørensen, J. A., 1. sep. 2019, I : Journal of Molecular Diagnostics. 21, 5, s. 790-795

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Population
Neoplasms
Research Personnel
DNA Sequence Analysis
Cluster Analysis
DNA
Neoplasms
Mutation
Residual Neoplasm
2018

A Danish national effort of BRCA1/2 variant classification

Pedersen, I. S., Schmidt, A. Y., Bertelsen, B., Ernst, A., Andersen, C. L. T., Kruse, T., Rossing, M. & Thomassen, M., 2. jan. 2018, I : Acta Oncologica. 57, 1, s. 159-162

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

116 Downloads (Pure)

Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer

Block, I., Burton, M., Sørensen, K. P., Andersen, L., Larsen, M. J., Bak, M., Cold, S., Thomassen, M., Tan, Q. & Kruse, T. A., 6. feb. 2018, I : OncoTarget. 9, 10, s. 9030-9042

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37 Downloads (Pure)

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Lu, Y., Beeghly-Fadiel, A., Wu, L., Guo, X., Li, B., Schildkraut, J. M., Im, H. K., Chen, Y. A., Permuth, J. B., Reid, B. M., Teer, J. K., Moysich, K. B., Andrulis, I. L., Anton-Culver, H., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Benitez, J., Bjorge, L. & 124 flere, Brenton, J., Butzow, R., Caldes, T., Caligo, M. A., Campbell, I., Chang-Claude, J., Claes, K. B. M., Couch, F. J., Cramer, D. W., Daly, M. B., deFazio, A., Dennis, J., Diez, O., Domchek, S. M., Dörk, T., Easton, D. F., Eccles, D. M., Fasching, P. A., Fortner, R. T., Fountzilas, G., Friedman, E., Ganz, P. A., Garber, J., Giles, G. G., Godwin, A. K., Goldgar, D. E., Goodman, M. T., Greene, M. H., Gronwald, J., Hamann, U., Heitz, F., Hildebrandt, M. A. T., Høgdall, C. K., Hollestelle, A., Hulick, P. J., Huntsman, D. G., Imyanitov, E. N., Isaacs, C., Jakubowska, A., James, P., Karlan, B. Y., Kelemen, L. E., Kiemeney, L. A., Kjaer, S. K., Kwong, A., Le, N. D., Leslie, G., Lesueur, F., Levine, D. A., Mattiello, A., May, T., McGuffog, L., McNeish, I. A., Merritt, M. A., Modugno, F., Montagna, M., Neuhausen, S. L., Nevanlinna, H., Nielsen, F. C., Nikitina-Zake, L., Nussbaum, R. L., Offit, K., Olah, E., Olopade, O. I., Olson, S. H., Olsson, H., Osorio, A., Park, S. K., Parsons, M. T., Peeters, P. H. M., Pejovic, T., Peterlongo, P., Phelan, C. M., Pujana, M. A., Ramus, S. J., Rennert, G., Risch, H., Rodriguez, G. C., Rodríguez-Antona, C., Romieu, I., Rookus, M. A., Rossing, M. A., Rzepecka, I. K., Sandler, D. P., Schmutzler, R. K., Setiawan, V. W., Sharma, P., Sieh, W., Simard, J., Singer, C. F., Song, H., Southey, M. C., Spurdle, A. B., Sutphen, R., Swerdlow, A. J., Teixeira, M. R., Teo, S. H., Thomassen, M., Tischkowitz, M., Toland, A. E., Trichopoulou, A., Tung, N., Tworoger, S. S., van Rensburg, E. J., Vanderstichele, A., Vega, A., Edwards, D. V., Webb, P. M., Weitzel, J. N., Wentzensen, N., White, E., Wolk, A., Wu, A. H., Yannoukakos, D., Zorn, K. K., Gayther, S. A., Antoniou, A. C., Berchuck, A., Goode, E. L., Chenevix-Trench, G., Sellers, T. A., Pharoah, P. D. P., Zheng, W. & Long, J., 15. sep. 2018, I : Cancer Research. 78, 18, s. 5419-5430

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Transcriptome
Genome-Wide Association Study
RNA Sequence Analysis

Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG

Soenderstrup, I. M. H., Laenkholm, A. V., Jensen, M. B., Eriksen, J. O., Gerdes, A. M., Hansen, T. V. O., Kruse, T. A., Larsen, M. J., Pedersen, I. S., Rossing, M., Thomassen, M. & Ejlertsen, B., jan. 2018, I : Acta Oncologica. 57, 1, s. 95-101

Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

Disease-Free Survival
Neoplasms
Mutation
Proportional Hazards Models
Paraffin
82 Downloads (Pure)

Differential effect of surgical manipulation on gene expression in normal breast tissue and breast tumor tissue

Pedersen, I. S., Thomassen, M., Tan, Q., Kruse, T. A., Thorlacius-Ussing, O., Garne, J. P. & Krarup, H. B., 16. nov. 2018, I : Molecular Medicine. 24, 8 s., 57.

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Neoplasms
Gene Expression Profiling
Transcriptome
Freezing
69 Downloads (Pure)

Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer

French COVAR group collaborators, 3. apr. 2018, I : Oncotarget. 9, 25, s. 17334-17348

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Ovarian Neoplasms
BRCA2 Gene
France
Virulence
BRCA1 Gene
105 Downloads (Pure)

Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression

Krøigård, A. B., Larsen, M. J., Lænkholm, A-V., Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Thomassen, M. & Kruse, T. A., 1. jan. 2018, I : PLOS ONE. 13, 1, 18 s., e0189887.

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metastasis
breast neoplasms
Genes
neoplasms
genes
38 Downloads (Pure)

Interim analysis of the Daliah trial - a randomized controlled phase iii clinical trial Comparing recombinant interferon alpha-2 vs. Hydroxyurea in MPN patients.

Knudsen, T. A., Lund Hansen, D., Ocias, L. F., Weiss Bjerrum, O., Brabrand, M., El Fassi, D., Frederiksen, M., Kjær, L., Kielsgaard Kristensen, T., Kruse, T. A., Mourits-Andersen, H. T., Møller, P., Overgaard, U. M., Severinsen, M. T., Skov, V. H., Stentoft, J., Starklint, J., de Stricker, K., Thomassen, M., Larsen, T. S. & 1 flere, Hasselbalch, H. C., 15. jun. 2018, I : HemaSphere. 2, S1, s. 18-19 S131.

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71 Downloads (Pure)

Lecocytes mutation load declines with age in carriers of the m.3243A>G mutation: A 10-year Prospective Cohort

Langdahl, J. H., Larsen, M., Frost, M., Andersen, P. H., Yderstraede, K. B., Vissing, J., Dunø, M., Thomassen, M. & Frederiksen, A. L., apr. 2018, I : Clinical Genetics. 93, 4, s. 925-928

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antineoplaston A10
Mutation
Longitudinal Studies

Molecular heterogeneity of mantle cell lymphoma

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 4. maj 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

128 Downloads (Pure)

Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations

Rebbeck, T. R., Friebel, T. M., Friedman, E., Hamann, U., Huo, D., Kwong, A., Olah, E., Olopade, O. I., Solano, A. R., Teo, S-H., Thomassen, M., Weitzel, J. N., Chan, T. L., Couch, F. J., Goldgar, D. E., Kruse, T. A., Palmero, E. I., Park, S. K., Torres, D., van Rensburg, E. J. & 31 flere, McGuffog, L., Parsons, M. T., Leslie, G., Aalfs, C. M., Abugattas, J., Adlard, J., Agata, S., Aittomäki, K., Andrews, L., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Asseryanis, E., Auerbach, L., Azzollini, J., Balmaña, J., Barile, M., Barkardottir, R. B., Barrowdale, D., Benitez, J., Berger, A., Berger, R., Blanco, A. M., Blazer, K. R., Blok, M. J., Bonadona, V., Gerdes, A-M., Nielsen, H. R., Skytte, A-B. & EMBRACE, maj 2018, I : Human Mutation. 39, 5, s. 593-620

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Mutation
Population
Research Personnel
Germ-Line Mutation
Mutation Rate

Myeloproliferative Neoplasms in Danish Twins

Andersen, M. A., Bjerrum, O. W., Ranjan, A., Skov, V., Kruse, T. A., Thomassen, M., Skytthe, A., Hasselbalch, H. C. & Christensen, K., 3. maj 2018, I : Acta Haematologica. 139, 3, s. 195-198

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Neoplasms
Monozygotic Twins
Registries
Dizygotic Twins
Cell Lineage

NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. jun. 2018.

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NEW POTENTIAL CANDIDATE GENES IN MANTLE CELL LYMPHOMA

Cédile, O., Hansen, M. C., Ebbesen, L. H., Nørgaard Bentzen, H. H., Thomassen, M., Kruse, T. A., Kavan, S., Møller, M. B., Kielsgaard Kristensen, T., Christensen, J. H., Abildgaard, N. & Nyvold, C. G., 14. jun. 2018, I : EHA Learning Center. 2018, PB2322.

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Publisher Correction: Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations (Scientific Reports, (2017), 7, 1, (6774), 10.1038/s41598-017-07057-3)

Nielsen, H. M., Andersen, C. L., Westman, M., Kristensen, L. S., Asmar, F., Kruse, T. A., Thomassen, M., Larsen, T. S., Skov, V., Hansen, L. L., Bjerrum, O. W., Hasselbalch, H. C., Punj, V. & Grønbæk, K., 20. nov. 2018, I : Scientific Reports. 8, 1 s., 17311.

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Epigenomics
Mutation

SAFETY AND EFFICACY OF COMBINATION THERAPY OF INTERFERON ΑLPHA-2 AND RUXOLITINIB IN POLYCYTHEMIA VERA AND LOW-/INTERMEDIATE-1-RISK MYELOFIBROSIS – A ONE YEAR FOLLOW-UP UPDATE OF A PHASE II STUDY

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Skov, V., Andersen, C. B. L., Weiss Bjerrum, O., Brochmann Mortensen, N., El Fassi, D., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M. & Hasselbalch, H. C., jun. 2018, I : EHA Learning Center. 2018, PF620.

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116 Downloads (Pure)

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

Mikkelsen, S. U., Kjær, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Andersen, C. B. L., Bjerrum, O. W., Brochmann, N., Fassi, D. E., Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, C. H., Pallisgaard, N., Thomassen, M., Skov, V. & Hasselbalch, H. C., 1. aug. 2018, I : Cancer Medicine. 7, 8, s. 3571-3581

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Polycythemia Vera
Safety
INCB018424
Neoplasms
Alleles

Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

Kjaer, L., Holmström, M. O., Cordua, S., Andersen, M. H., Svane, I. M., Thomassen, M., Kruse, T. A., Pallisgaard, N., Skov, V. & Hasselbalch, H. C., apr. 2018, I : Leukemia and Lymphoma. 59, 4, s. 973-977

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The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium

Moghadasi, S., Meeks, H. D., Vreeswijk, M. P., Janssen, L. A., Borg, Å., Ehrencrona, H., Paulsson-Karlsson, Y., Wappenschmidt, B., Engel, C., Gehrig, A., Arnold, N., Hansen, T. V. O., Thomassen, M., Jensen, U. B., Kruse, T. A., Ejlertsen, B., Gerdes, A-M., Pedersen, I. S., Caputo, S. M., Couch, F. & 20 flere, Hallberg, E. J., van den Ouweland, A. M., Collée, M. J., Teugels, E., Adank, M. A., van der Luijt, R. B., Mensenkamp, A. R., Oosterwijk, J. C., Blok, M. J., Janin, N., Claes, K. B., Tucker, K., Viassolo, V., Toland, A. E., Eccles, D. E., Devilee, P., Van Asperen, C. J., Spurdle, A. B., Goldgar, D. E. & Garcia, E. B. G., jan. 2018, I : Journal of Medical Genetics. 55, 1, s. 15-20

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Ovarian Neoplasms
Alleles
Neoplasms
Ovariectomy
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Whole Blood Gene Expression Profiling in patients undergoing colon cancer surgery identifies differential expression of genes involved in immune surveillance, inflammation and carcinogenesis

Watt, S. K., Hasselbalch, H. C., Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M. & Gögenur, I., jun. 2018, I : Surgical Oncology. 27, 2, s. 208-215

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Gene Expression Profiling
Colonic Neoplasms
Ambulatory Surgical Procedures
Down-Regulation
Chemical Databases
2017
105 Downloads (Pure)

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Hamdi, Y., Soucy, P., Kuchenbaeker, K. B., Pastinen, T., Droit, A., Lemaçon, A., Adlard, J., Aittomäki, K., Andrulis, I. L., Arason, A., Arnold, N., Arun, B. K., Azzollini, J., Bane, A., Barjhoux, L., Barrowdale, D., Benítez, J., Berthet, P., Blok, M. J., Bobolis, K. A. & 31 flere, Bonadona, V., Bonanni, B., Bradbury, A. R., Brewer, C., Buecher, B., Buys, S., Caligo, M. A., Chiquette, J., Chung, W. K., Claes, K. B. M., Daly, M. B., Damiola, F., Davidson, R., de la Hoya, M., De Leeneer, K., Díez, O., Ding, Y. C., Dolcetti, R., Domchek, S. M., Dorfling, C. M., Eccles, D., Eeles, R., Einbeigi, Z., Ejlertsen, B., Engel, C., Gareth Evans, D., Feliubadaló, L., Foretova, L., Gerdes, A-M., Thomassen, M. & EMBRACE, 2017, I : Breast Cancer Research and Treatment. 161, 1, s. 117-134

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Heterozygote
Single Nucleotide Polymorphism
Mutation
Quantitative Trait Loci
Progesterone Receptors

Clinical outcomes of female breast cancer according to BRCA mutation status

Cronin-Fenton, D. P., Kjaersgaard, A., Norgaard, M., Pedersen, I. S., Thomassen, M., Kaye, J. A., Gutierrez, L., Telford, C., Lewis, J., Tyczynski, J. E. & Sorensen, H. T., 2017, I : Cancer Epidemiology. 49, s. 128-137

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Confidence Intervals
Mutation
Germ-Line Mutation
Denmark
Selection Bias
161 Downloads (Pure)

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Li, S., Zhu, D., Duan, H., Ren, A., Glintborg, D., Andersen, M., Skov, V., Thomassen, M., Kruse, T. & Tan, Q., 2017, I : Oncotarget. 8, 13, s. 20656-20666

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Polycystic Ovary Syndrome
DNA Methylation
Epigenomics
Prolactin
DNA
124 Downloads (Pure)

Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

Myrtue Nielsen, H., Lykkegaard Andersen, C., Westman, M., Sommer Kristensen, L., Asmar, F., Kruse, T. A., Thomassen, M., Stauffer Larsen, T., Skov, V., Lotte Hansen, L., Weis Bjerrum, O., Carl Hasselbalch, H., Punj, V. & Grønbæk, K., 2017, I : Scientific Reports. 7, 11 s., 6774.

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Epigenomics
Mutation
DNA Methylation
Histones
Nucleic Acid Regulatory Sequences
115 Downloads (Pure)

Generalized Correlation Coefficient for Non-Parametric Analysis of Microarray Time-Course Data

Tan, Q., Thomassen, M., Burton, M., Mose, K. F., Andersen, K. E., Hjelmborg, J. V. B. & Kruse, T. A., 2017, I : Journal of Integrative Bioinformatics. 14, 2, 20170011.

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Cluster Analysis
Health
135 Downloads (Pure)

Genomic analyses of breast cancer progression reveal distinct routes of metastasis emergence

Krøigård, A. B., Larsen, M. J., Brasch-Andersen, C., Lænkholm, A. V., Knoop, A. S., Jensen, J. D., Bak, M., Mollenhauer, J., Thomassen, M. & Kruse, T. A., 2017, I : Scientific Reports. 7, 9 s., 43813.

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Neoplasms
Exome
Clone Cells
Research
94 Downloads (Pure)

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Phelan, C. M., Kuchenbaecker, K. B., Tyrer, J. P., Kar, S. P., Lawrenson, K., Winham, S. J., Dennis, J., Pirie, A., Riggan, M. J., Chornokur, G., Earp, M. A., Lyra, P. C., Lee, J. M., Coetzee, S., Beesley, J., McGuffog, L., Soucy, P., Dicks, E., Lee, A., Barrowdale, D. & 31 flere, Lecarpentier, J., Leslie, G., Aalfs, C. M., Aben, K. K. H., Adams, M., Adlard, J., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Aravantinos, G., Arnold, N., Arun, B. K., Arver, B., Azzollini, J., Balmaña, J., Banerjee, S. N., Barjhoux, L., Barkardottir, R. B., Bean, Y., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bermisheva, M., Bernardini, M. Q., Birrer, M. J., Bjorge, L., Bojesen, A., Gerdes, A-M., Kruse, T. A., Thomassen, M. & AOCS study group, 2017, I : Nature Genetics. 49, 5, s. 680-691

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Mutation
Ovarian Neoplasms
Meta-Analysis
Alleles
106 Downloads (Pure)

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Adams, M., Adlard, J., Agata, S. & 31 flere, Ahmed, S., Ahsan, H., Aittomäki, K., Al-Ejeh, F., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. E. M., Azzollini, J., Bacot, F., Balmaña, J., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Bojesen, A., Gerdes, A-M., Kruse, T. A., Lænkholm, A-V., Thomassen, M. & ABCTB Investigators, 2017, I : Nature Genetics. 49, 12, s. 1767–1778

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Genome-Wide Association Study
Mutation

Investigating a case of possible field cancerization in oral squamous cell carcinoma by the use of next-generation sequencing

Tabatabaeifar, S., Larsen, M. J., Larsen, S. R., Kruse, T. A., Thomassen, M. & Sørensen, J. A., 2017, I : Oral Oncology. 68, s. 74-80

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Mutation
Neoplasms
Oral Stage
Exome
Paraffin
81 Downloads (Pure)

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-Hoeyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T. A., Thomassen, M., Troelsen, J., Hasselbalch, H. C. & Ottesen, J. T., 2017, I : PLOS ONE. 12, 8, 18 s., e0183620.

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Stem cells
mathematical models
inflammation
neoplasms
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