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  • Moustapha Kassem
2019

Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study

Frost, M., Tencerova, M., Andreasen, C. M., Levin Andersen, T., Ejersted, C. A., Svaneby, D., Kassem, M., Whyte, M. P. & Frederiksen, A. L., apr. 2019, I : Bone. 121, s. 243-254

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Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Nehlin, J. O., Jafari, A., Tencerova, M. & Kassem, M., 1. jun. 2019, I : Bone. 123, s. 265-273

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Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation

El-Safadi, M., Shinwari, T., Al-Malki, S., Manikandan, M., Mahmood, A., Aldahmash, A., Alfayez, M., Kassem, M. & Alajez, N. M., 21. mar. 2019, I : Scientific Reports. 9, 13 s., 4977.

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CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors

Al-Toub, M., Almohawes, M., Vishnubalaji, R., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 2019, I : Cell Death Discovery. 5, 9 s., 87.

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Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease

Dige, A., Hougaard, H. T., Agnholt, J., Pedersen, B. G., Tencerova, M., Kassem, M., Krogh, K. & Lundby, L., 1. jun. 2019, I : Gastroenterology. 156, 8, s. 2208-2216.e1

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ESTABLISHMENT OF A KNOCKDOWN MODEL FOR UNRAVELLING THE PATHOGENESIS OF MANTLE CELL LYMPHOMA

Valentin Hansen, S., Cédile, O., Hansen, M. C., Christensen, J. H., Chen, L., Kassem, M., Abildgaard, N. & Nyvold, C. G., jun. 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

Almuraikhi, N., Almasoud, N., Binhamdan, S., Younis, G., Ali, D., Manikandan, M., Vishnubalaji, R., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2019, I : Stem Cells International. 2019, 12 s., 3435901.

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Identification of novel factors involved in the coupling of bone resorption and bone formation in humans reveals RANKL/DPP4 as a new link between bone remodeling and energy metabolism

Weivoda, M., Chew, C. K., Monroe, D., Atkinson, E., Farr, J., Thicke, B., Ruan, M., Tweed, A., Eckhardt, B., McCready, L., Geske, J., Rizza, R., Vella, A., Matveyenko, A., Drake, M., Clarke, B., Oursler, M. J., Khosla, S., Kassem, M. & Andersen, T., dec. 2019, I : Journal of Bone and Mineral Research. 34, Suppl. 1, s. 18 1 s., 1051.

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Insulin Signaling in Bone Marrow Adipocytes

Tencerova, M., Okla, M. & Kassem, M., dec. 2019, I : Current Osteoporosis Reports (Print). 17, 6, s. 446-454

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In Vitro and In Vivo Evaluation of 1-(3 Dimethylaminopropyl)-3-Ethyl Carbodiimide (EDC) Cross-Linked Gum Arabic–Gelatin Composite as an Ideal Porous Scaffold for Tissue Engineering

Edwin, B. T., Dhanya, H., Nair, P. D. & Kassem, M., 2019, Biomaterials in Orthopaedics and Bone Regeneration: Design and Synthesis. Bains, P. S., Sidhu, S. S., Bahraminasab, M. & Prakash, C. (red.). Springer, s. 131-145 (Materials Horizons: From Nature to Nanomaterials ).

Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskningpeer review

KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment

Chen, L., Shi, K., Andersen, T. L., Qiu, W. & Kassem, M., 12. feb. 2019, I : Cell Death and Disease. 10, 2, s. 1-13 126.

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Lansoprazole inhibits the cysteine protease legumain by binding to the active site

Bosnjak, T., Solberg, R., Hemati, P. D., Jafari, A., Kassem, M. & Johansen, H. T., aug. 2019, I : Basic & Clinical Pharmacology & Toxicology. 125, 2, s. 89-99

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Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation

Falster, C., Poulsen, S. S., Storaas, A. M., Schroeder, H. M., Vinther, J. H., Kassem, M. & Joergensen, U., 1. sep. 2019, I : Journal of Orthopaedic Science. 24, 5, s. 918-924

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Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

Tencerova, M., Rendina-Ruedy, E., Neess, D., Færgeman, N., Figeac, F., Ali, D., Danielsen, M., Haakonsson, A., Rosen, C. J. & Kassem, M., 1. dec. 2019, I : Bone Research. 7, 14 s., 35.

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Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B

Vishnubalaji, R., Elango, R., Al-Toub, M., Manikandan, M., Al-Rikabi, A., Harkness, L., Ditzel, N., Atteya, M., Hamam, R., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 1. dec. 2019, I : Scientific Reports. 9, 14 s., 8101.

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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

Almuraikhi, N., Ali, D., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 22. aug. 2019, I : Stem Cells International. 2019, 13 s., 3041262.

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Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Rauch, A., Haakonsson, A. K., Madsen, J. G. S., Larsen, M., Forss, I., Madsen, M. R., Van Hauwaert, E. L., Wiwie, C., Jespersen, N. Z., Tencerova, M., Nielsen, R., Larsen, B. D., Röttger, R., Baumbach, J., Scheele, C., Kassem, M. & Mandrup, S., apr. 2019, I : Nature Genetics. 51, 4, s. 716-727

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Strontium functionalized scaffold for bone tissue engineering

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M., 1. jan. 2019, I : Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems. 94, s. 509-515

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TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling

Jafari, A., Isa, A., Chen, L., Ditzel, N., Zaher, W., Harkness, L., Johnsen, H. E., Abdallah, B. M., Clausen, C. & Kassem, M., 1. mar. 2019, I : Stem Cells. 37, 3, s. 407-416

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Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Walker, J. V., Zhuang, H., Singer, D., Illsley, C. S., Kok, W. L., Sivaraj, K. K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P. R. C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., Yang, K. & 7 flere, Bai, Y., Tredwin, C., Zambon, A. C., Corbeil, D., Adams, R., Abdallah, B. M. & Hu, B., 9. aug. 2019, I : Nature Communications. 10, 1, 18 s., 3596.

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2018

Actin depolymerization enhances adipogenic differentiation in human stromal stem cells

Chen, L., Hu, H., Qiu, W., Shi, K. & Kassem, M., 1. maj 2018, I : Stem Cell Research. 29, s. 76-83

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Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice

Figeac, F., Andersen, D. C., Nipper Nielsen, C. A., Ditzel, N., Sheikh, S. P., Skjødt, K., Kassem, M., Jensen, C. H. & Abdallah, B. M., maj 2018, I : Bone. 110, s. 312-320

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Bioactive Nano-fibrous Scaffold for Vascularized Craniofacial Bone Regeneration

Prabha, R. D., Kraft, D. C. E., Harkness, L., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M., mar. 2018, I : Journal of Tissue Engineering and Regenerative Medicine. 12, 3, s. e1537-e1548

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Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report

Byberg, S., Abrahamsen, B., Kassem, M., Ralston, S. & Schwarz, P., 27. sep. 2018, I : Journal of Medical Case Reports. 12, 6 s., 278.

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Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

Schmal, H., Kowal, J. M., Kassem, M., Seidenstuecker, M., Bernstein, A., Böttiger, K., Xiong, T., Südkamp, N. P. & Kubosch, E. J., 1. jan. 2018, I : Stem Cells International. 2018, 12 s., 4142031.

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Detection of differential protein expression patterns in osteogenic and adipogenic lineages of bone marrow derived stromal (mesenchymal) stem cells

Facchinetti, G., Rozanova, S., Kowal, J., Kassem, M., Gemoll, T. & Habermann, J., 2018, I : Oncology Research and Treatment. 41, Suppl. 1, s. 125 1 s.

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Establishing lobular-like and interlobular-like fibroblast cell lines from human breast reduction mammoplasties

Morsing, M., Jafari, A., Kassem, M., Petersen, O. W. & Ronnov-Jessen, L., jul. 2018, I : Cancer research. 78, Suppl. 13, 1010.

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Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration

Chang, C-C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M. & Kjems, J., 7. feb. 2018, I : Molecular Therapy. 26, 2, s. 593-605

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Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics

Rumman, M., Majumder, A., Harkness, L., Venugopal, B., Vinay, M. B., Pillai, M. S., Kassem, M. & Dhawan, J., jul. 2018, I : Stem Cell Research. 30, s. 69-80

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International Harmonization and Standardization between Denmark and Germany: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Wendlandt, R., Kowal, J. M., Haakonsson, A. K., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H., Frahm, T., Eckers, A. & 5 flere, Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 31. jul. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Leif Mosekilde IN MEMORIAM

Rejnmark, L., Brixen, K., Kassem, M., Hermann, P., Vestergaard, P., Eriksen, E. F., Bollerslev, J., Nielsen, H. K., Charles, P. & Langdahl, B., nov. 2018, I : Journal of Bone and Mineral Research. 33, 11, 1 s.

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Lower Insulin Sensitivity in Patients With High Bone Mass due to a LRP5T253I mutation

Lauterlein, J-J. L., Hermann, A. P., Kassem, M., Hojlund, K. & Frost, M., 1. nov. 2018, I : Journal of Bone and Mineral Research. 33, Suppl. 1, s. 40 1 s.

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Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses

Twine, N. A., Harkness, L., Adjaye, J., Aldahmash, A., Wilkins, M. R. & Kassem, M., sep. 2018, I : JBMR Plus. 2, 5, s. 257-267

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Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress prosurvival signalling pathways

Vishnubalaji, R., Manikandan, M., Fahad, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2. mar. 2018, I : OncoTarget. 9, 17, s. 13551-13564

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Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells

Ayesh Hafez Ali, D., Abuelreich, S., Alkeraishan, N., Shwish, N. B., Hamam, R., Kassem, M., Alfayez, M., Aldahmash, A. & Alajez, N. M., 30. jan. 2018, I : Bioscience Reports. 38, 1, 10 s., BSR20171252.

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NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC

Manikandan, M., Abuelreich, S., Elsafadi, M., Alsalman, H., Almalak, H., Siyal, A., Hashmi, J. A., Aldahmash, A., Kassem, M., Alfayez, M. & Mahmood, A., 1. nov. 2018, I : Differentiation. 104, s. 36-41

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Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity

Ali, D., Chalisserry, E. P., Manikandan, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2018, I : Stem Cells International. 2018, 12 s., 2379546.

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Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

Abdallah, B., Alzahrani, A. M. & Kassem, M., maj 2018, I : Bone. 110, s. 221-229

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Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells

AlMuraikhi, N., Ali, D., Alshanwani, A., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2018, I : Stem Cell Research & Therapy. 9, 10 s., 319.

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TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

Elsafadi, M., Manikandan, M., Almalki, S., Mobarak, M., Atteya, M., Iqbal, Z., Hashmi, J. A., Shaheen, S., Alajez, N., Alfayez, M., Kassem, M., Dawud, R. A. & Mahmood, A., 2018, I : Stem Cells International. 2018, 14 s., 6913594.

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2016

Aging and bone

Gimble, J. M., Floyd, Z. E., Kassem, M. & Nuttall, M. E., 2016, Osteoporosis in Older Persons: Advances in Pathophysiology and Therapeutic Approaches. Duque, G. & Kiel, D. P. (red.). 2. udg. Springer, s. 23-42

Publikation: Kapitel i bog/rapport/konference-proceedingKapitel i bogForskningpeer review

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Vishnubalaji, R., Yue, S., Alfayez, M., Kassem, M., Liu, FF., Aldahmash, A. & Alajez, N. M., 29. sep. 2016, I : Cancer Cell International. 16, 12 s., 77.

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CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

Harkness, L., Zaher, W., Ditzel, N., Isa, A. & Kassem, M., 2016, I : Stem Cell Research & Therapy. 7, 1, s. 4-16 13 s.

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