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2019

Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study

Frost, M., Tencerova, M., Andreasen, C. M., Levin Andersen, T., Ejersted, C. A., Svaneby, D., Kassem, M., Whyte, M. P. & Frederiksen, A. L., apr. 2019, I : Bone. 121, s. 243-254

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Osteopetrosis
Case-Control Studies
Mutation
Incontinentia Pigmenti
X Chromosome Inactivation

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Nehlin, J. O., Jafari, A., Tencerova, M. & Kassem, M., 1. jun. 2019, I : Bone. 123, s. 265-273

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Stromal Cells
Adipocytes
Physiological Phenomena
Adiposity
Osteoblasts
92 Downloads (Pure)

A simple and reliable protocol for long-term culture of murine bone marrow stromal (mesenchymal) stem cells that retained their in vitro and in vivo stemness in long-term culture

Abdallah, B. M., Alzahrani, A. M., Abdel-Moneim, A. M., Ditzel, N. & Kassem, M., feb. 2019, I : Biological Procedures Online. 21, 11 s., 3.

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Mesenchymal Stromal Cells
Osteoblasts
Population
Fibroblast Growth Factor 2
Stromal Cells
Adipogenesis
Stem Cell Factor
Osteogenesis
Color
108 Downloads (Pure)

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation

El-Safadi, M., Shinwari, T., Al-Malki, S., Manikandan, M., Mahmood, A., Aldahmash, A., Alfayez, M., Kassem, M. & Alajez, N. M., 21. mar. 2019, I : Scientific Reports. 9, 13 s., 4977.

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Mesenchymal Stromal Cells
Cell Differentiation
Up-Regulation
Regenerative Medicine
Gene Expression Profiling
64 Downloads (Pure)

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors

Al-Toub, M., Almohawes, M., Vishnubalaji, R., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 2019, I : Cell Death Discovery. 5, 9 s., 87.

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Stem Cell Factor
Mesenchymal Stromal Cells
Neoplasms
Stromal Cells
Conditioned Culture Medium

Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease

Dige, A., Hougaard, H. T., Agnholt, J., Pedersen, B. G., Tencerova, M., Kassem, M., Krogh, K. & Lundby, L., 1. jun. 2019, I : Gastroenterology. 156, 8, s. 2208-2216.e1

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Crohn Disease
Adipose Tissue
Cutaneous Fistula
Lipectomy
Perineum

ESTABLISHMENT OF A KNOCKDOWN MODEL FOR UNRAVELLING THE PATHOGENESIS OF MANTLE CELL LYMPHOMA

Valentin Hansen, S., Cédile, O., Hansen, M. C., Christensen, J. H., Chen, L., Kassem, M., Abildgaard, N. & Nyvold, C. G., jun. 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

Almuraikhi, N., Almasoud, N., Binhamdan, S., Younis, G., Ali, D., Manikandan, M., Vishnubalaji, R., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2019, I : Stem Cells International. 2019, 12 s., 3435901.

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Hedgehogs
Osteoblasts
Mesenchymal Stromal Cells
Osteogenesis
Gene Expression Profiling

Insulin Signaling in Bone Marrow Adipocytes

Tencerova, M., Okla, M. & Kassem, M., dec. 2019, I : Current Osteoporosis Reports. 17, 6, s. 446-454

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Adipocytes
Insulin
Fats
Cell Aging
Adiposity
82 Downloads (Pure)

KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment

Chen, L., Shi, K., Andersen, T. L., Qiu, W. & Kassem, M., 12. feb. 2019, I : Cell Death and Disease. 10, 2, s. 1-13 126.

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Cell Movement
Osteogenesis
Actins
CD44 Antigens
Stromal Cells

Lansoprazole inhibits the cysteine protease legumain by binding to the active site

Bosnjak, T., Solberg, R., Hemati, P. D., Jafari, A., Kassem, M. & Johansen, H. T., aug. 2019, I : Basic & Clinical Pharmacology & Toxicology. 125, 2, s. 89-99

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

asparaginylendopeptidase
Lansoprazole
Cysteine Proteases
Proton Pump Inhibitors
Catalytic Domain

Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation

Falster, C., Poulsen, S. S., Storaas, A. M., Schroeder, H. M., Vinther, J. H., Kassem, M. & Joergensen, U., 1. sep. 2019, I : Journal of Orthopaedic Science. 24, 5, s. 918-924

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Knee Osteoarthritis
Mesenchymal Stromal Cells
Osteogenesis
Wounds and Injuries
Knee
19 Downloads (Pure)

Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

Tencerova, M., Rendina-Ruedy, E., Neess, D., Færgeman, N., Figeac, F., Ali, D., Danielsen, M., Haakonsson, A., Rosen, C. J. & Kassem, M., 1. dec. 2019, I : Bone Research. 7, 14 s., 35.

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Mesenchymal Stromal Cells
Adipocytes
Oxidative Phosphorylation
Insulin
Osteoblasts
74 Downloads (Pure)

Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B

Vishnubalaji, R., Elango, R., Al-Toub, M., Manikandan, M., Al-Rikabi, A., Harkness, L., Ditzel, N., Atteya, M., Hamam, R., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 1. dec. 2019, I : Scientific Reports. 9, 14 s., 8101.

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Mesenchymal Stromal Cells
Sarcoma
Linear Energy Transfer
Mesoderm
Osteoblasts
44 Downloads (Pure)

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

Almuraikhi, N., Ali, D., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 22. aug. 2019, I : Stem Cells International. 2019, 13 s., 3041262.

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Osteoblasts
Mesenchymal Stromal Cells
Osteogenesis
Gene Expression Profiling
Alkaline Phosphatase
102 Downloads (Pure)
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Stem cells
Mesenchymal Stromal Cells
Bone
Insulin
RNA Sequence Analysis

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Rauch, A., Haakonsson, A. K., Madsen, J. G. S., Larsen, M., Forss, I., Madsen, M. R., Van Hauwaert, E. L., Wiwie, C., Jespersen, N. Z., Tencerova, M., Nielsen, R., Larsen, B. D., Röttger, R., Baumbach, J., Scheele, C., Kassem, M. & Mandrup, S., apr. 2019, I : Nature Genetics. 51, 4, s. 716-727

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Adipogenesis
Stem Cell Factor
Mesenchymal Stromal Cells
Osteogenesis
Chromatin Assembly and Disassembly
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Mesenchymal Stromal Cells
Osteoblasts
Translational Medical Research
Adipocytes
Osteogenesis

Strontium functionalized scaffold for bone tissue engineering

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M., 1. jan. 2019, I : Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems. 94, s. 509-515

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strontium ranelate
Tissue Engineering
Stromal Cells
Growth
Dentistry
54 Downloads (Pure)

TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling

Jafari, A., Isa, A., Chen, L., Ditzel, N., Zaher, W., Harkness, L., Johnsen, H. E., Abdallah, B. M., Clausen, C. & Kassem, M., 1. mar. 2019, I : Stem Cells. 37, 3, s. 407-416

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Stromal Cells
Mesenchymal Stromal Cells
Cell Movement
Closed Fractures
Pseudopodia
39 Downloads (Pure)

Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Walker, J. V., Zhuang, H., Singer, D., Illsley, C. S., Kok, W. L., Sivaraj, K. K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P. R. C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., Yang, K. & 7 flere, Bai, Y., Tredwin, C., Zambon, A. C., Corbeil, D., Adams, R., Abdallah, B. M. & Hu, B., 9. aug. 2019, I : Nature Communications. 10, 1, 18 s., 3596.

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stem cells
Incisor
transit
Stem cells
Mesenchymal Stromal Cells
2017

Bone and Skeletal Stem Cells are Affected in High Fat Diet Mice

Figeac, F., Tencerova, M., Ditzel, N., Nielsen, T. K. L., Jørgensen, B. & Kassem, M., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D., Whyte, M. P. & Frederiksen, A. L., 2017.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D. V., Whyte, M. P. & Frederiksen, A. L., dec. 2017, I : Journal of Bone and Mineral Research. 32, S1, s. S395 1 s., MO0710.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

154 Downloads (Pure)

CHD1 regulates cell fate determination by activation of differentiation-induced genes

Baumgart, S. J., Najafova, Z., Hossan, T., Xie, W., Nagarajan, S., Kari, V., Ditzel, N., Kassem, M. & Johnsen, S. A., 2017, I : Nucleic Acids Research. 45, 13, s. 7722-7735

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DNA-Binding Proteins
Osteoblasts
Nucleosomes
RNA Polymerase II
Osteogenesis
88 Downloads (Pure)

Chromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cells

Burns, J. S., Harkness, L., Aldahmash, A., Gautier, L. & Kassem, M., 2017, I : Stem Cell Research. 25, s. 6-17

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Mesenchymal Stromal Cells
Diploidy
Comparative Genomic Hybridization
Cell Cycle Checkpoints
Computational Biology
156 Downloads (Pure)

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M., Zaher, W., Alfayez, M., Aldahmash, A. & Alajez, N. M., 7. sep. 2017, I : Cell Death & Disease. 8, 9, 12 s., e3045.

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MicroRNAs
Physiologic Monitoring
Nucleic Acids
Messenger RNA
DNA

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling

Abdallah, B. M., Figeac, F., Larsen, K. H., Ditzel, N., Keshari, P., Isa, A., Jafari, A., Andersen, T. L., Delaisse, J. M., Goshima, Y., Ohshima, T. & Kassem, M., maj 2017, I : Journal of Bone and Mineral Research. 32, 5, s. 913-926

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Osteoblasts
Osteogenesis
Proteins
Mesenchymal Stromal Cells
Cyclin D1

Cross-border biobanking: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Waizner, K., Wendlandt, R., Zweig, W., Kowal, J. M., Haakonsson, A., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H. & 12 flere, Duckert, R., Kroeger, I., Stueck, G., Kessel, S., Hecht, M., Frahm, T., Eckers, A., Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

CUDC-907 Promotes Bone Marrow Adipocytic Differentiation Through Inhibition of Histone Deacetylase and Regulation of Cell Cycle

Ali, D., Alshammari, H., Vishnubalaji, R., Chalisserry, E. P., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2017, I : Stem Cells and Development. 26, 5, s. 353-362

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Histone Deacetylases
Adipocytes
Cell Cycle
Mesenchymal Stromal Cells
Epigenomics

Effects of GIP, GLP-1 and GLP-1RAs on bone cell metabolism

Hansen, M. S., Tencerova, M., Frølich, J. S., Kassem, M. & Frost, M., 2017, I : Basic & Clinical Pharmacology & Toxicology.

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Impact of Calcium and Two Doses of Vitamin D on Bone Metabolism in the Elderly: A Randomized Controlled Trial

Rahme, M., Sharara, S. L., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T., Bassil, D., El Ferkh, K. & El-Hajj Fuleihan, G., 2017, I : Journal of Bone and Mineral Research. 32, 7, s. 1486-1495

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National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Randomized Controlled Trials
Calcium Citrate
Hip
Body Mass Index

Legumain is a Novel Regulator of Bone Formation and Deregulated in Postmenopausal Osteoporosis

Jafari, A., Qanie, D. W. M., Levin Andersen, T., Chen, L., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaissé, J-M., Abdallah, B., Hesselson, D., Solberg, R. & Kassem, M., feb. 2017, I : Journal of Bone and Mineral Research. 31, S1, FR0152.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

226 Downloads (Pure)

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Levin Andersen, T., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., 2017, I : Stem Cell Reports. 8, 2, s. 373-386

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asparaginylendopeptidase
Postmenopausal Osteoporosis
Mesenchymal Stromal Cells
Bone
Osteoblasts
312 Downloads (Pure)

MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3

Elsafadi, M., Manikandan, M., Alajez, N. M., Hamam, R., Dawud, R. A., Aldahmash, A., Iqbal, Z., Alfayez, M., Kassem, M. & Mahmood, A., 2017, I : Stem Cell Research. 20, s. 94-104

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Lipoprotein Receptors
MicroRNAs
Mesenchymal Stromal Cells
Proteins
Clone Cells
250 Downloads (Pure)

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells

Elsafadi, M., Manikandan, M., Atteya, M., Abu Dawud, R., Almalki, S., Ali Kaimkhani, Z., Aldahmash, A., Alajez, N. M., Alfayez, M., Kassem, M. & Mahmood, A., 2017, I : Scientific Reports. 7, 15 s., 10797.

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Osteoblasts
Mesenchymal Stromal Cells
Adipocytes
Cell Differentiation
Fatty Acids
237 Downloads (Pure)

Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion

Slots, C., Bonde Jensen, M., Ditzel, N., Hedegaard, M. A. B., Borg, S. W., Albrektsen, O., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2017, I : Dental Materials. 33, 2, s. 198–208

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3D printers
Ink
Extrusion
Suspensions
Phosphates

The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo

Bonde Jensen, M., Slots, C., Ditzel, N., Hedegaard, M. A. B., Andersen, T. E., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2. nov. 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

103 Downloads (Pure)

The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation

Bermeo, S., Al-Saedi, A., Kassem, M., Vidal, C. & Duque, G., 2017, I : Journal of Cellular Biochemistry. 118, 12, s. 4425–4435

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Nuclear Proteins
Mesenchymal Stromal Cells
Osteogenesis
Adipogenesis
Cell Differentiation
2016

Aging and bone

Gimble, J. M., Floyd, Z. E., Kassem, M. & Nuttall, M. E., 2016, Osteoporosis in Older Persons: Advances in Pathophysiology and Therapeutic Approaches. Duque, G. & Kiel, D. P. (red.). 2. udg. Springer, s. 23-42

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

273 Downloads (Pure)

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Vishnubalaji, R., Yue, S., Alfayez, M., Kassem, M., Liu, FF., Aldahmash, A. & Alajez, N. M., 2016, I : Cancer Cell International. 16, 12 s., 77.

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Colonic Neoplasms
Colorectal Neoplasms
Growth
SCID Mice
Computational Biology
88 Downloads (Pure)

CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

Harkness, L., Zaher, W., Ditzel, N., Isa, A. & Kassem, M., 2016, I : Stem Cell Research & Therapy. 7, 1, s. 4-16 13 s.

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Stem cells
Mesenchymal Stromal Cells
Bone
Population
Cells
564 Downloads (Pure)

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells

Elsafadi, M., Manikandan, M., Atteya, M., Hashmi, J. A., Iqbal, Z., Aldahmash, A., Alfayez, M., Kassem, M. & Mahmood, A., 2016, I : Stem Cells International. 2016, 18 s., 9378081.

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Mesenchymal Stromal Cells
Alkaline Phosphatase
Stromal Cells
Osteoblasts
Homeobox Genes
155 Downloads (Pure)

Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction

Wright, E. J., Hodson, N. W., Sherratt, M. J., Kassem, M., Lewis, A. L., Wallrapp, C., Malik, N. & Holt, C. M., 2016, I : Stem Cells International. 2016, 13 s., 7357096.

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Mesenchymal Stromal Cells
Apoptosis
Atomic Force Microscopy
Conditioned Culture Medium
Polymerase Chain Reaction
126 Downloads (Pure)

Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy

Aggerholm-Pedersen, N., Demouth, C., Safwat, A., Meldgaard, P., Kassem, M. & Sorensen, B. S., 2016, I : Stem Cells International. 2016, 8 s., 9601493.

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Sarcoma
Epidermal Growth Factor Receptor
Cell Survival
Cell Line
Transformed Cell Line
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Osteoblasts
Homeostasis
Luciferases
Osteogenesis
Osteoclasts

Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial

Fuleihan G, EI-H., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Rahme, M., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T. & Kassir, M-F., 2016, I : The American Journal of Clinical Nutrition. 104, 2, s. 315-323

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Insulin Resistance
Randomized Controlled Trials
Homeostasis
Calcium Citrate
Prediabetic State
111 Downloads (Pure)

Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases

Hotez, P. J. & Kassem, M., 2016, I : P L o S Neglected Tropical Diseases (Online). 10, 12, 4 s., e0005072.

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113 Downloads (Pure)

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells

Ali, D., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2016, I : Stem Cells Translational Medicine. 5, 8, s. 1036-1047

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Mesenchymal Stromal Cells
Epigenomics
Stromal Cells
Libraries
Osteoblasts