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    Ole Nørregaard Jensen
2019

Differential Ion Mobility Separations/Mass Spectrometry with High Resolution in Both Dimensions

Baird, M. A., Anderson, G. A., Shliaha, P. V., Jensen, O. N. & Shvartsburg, A. A., 15. jan. 2019, I : Analytical Chemistry. 91, 2, s. 1479-1485 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pulse time modulation
Ultrahigh vacuum
Mass spectrometers
Isomers
Histones
43 Downloads (Pure)

FlashPack: Fast and simple preparation of ultra-high performance capillary columns for LC-MS

Kovalchuk, S. I., Jensen, O. N. & Rogowska-Wrzesinska, A., 1. feb. 2019, I : Molecular and Cellular Proteomics. 18, 2, s. 383-390

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Liquid chromatography
Liquid Chromatography
Sorbents
Biomolecules
Complex Mixtures

High-Resolution Differential Ion Mobility Separations/Orbitrap Mass Spectrometry without Buffer Gas Limitations

Baird, M. A., Shliaha, P. V., Anderson, G. A., Moskovets, E., Laiko, V., Makarov, A. A., Jensen, O. N. & Shvartsburg, A. A., 21. maj 2019, I : Analytical Chemistry. 91, 10, s. 6918-6925

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Mass spectrometry
Buffers
Gases
Ions
Vacuum

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

Radzisheuskaya, A., Shliaha, P. V., Grinev, V., Lorenzini, E., Kovalchuk, S., Shlyueva, D., Gorshkov, V., Hendrickson, R. C., Jensen, O. N. & Helin, K., nov. 2019, I : Nature Structural and Molecular Biology. 26, 11, s. 999-1012 32 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Protein-Arginine N-Methyltransferases
Acute Myeloid Leukemia
Myeloid Cells
Essential Genes
Alternative Splicing

Selective enrichment of phosphorylated peptides by monolithic polymers surface imprinted with bis-imidazolium moieties by UV-initiated cryopolymerization

Liu, M., Torsetnes, S. B., Wierzbicka, C., Jensen, O. N., Sellergren, B. & Irgum, K., 2019, I : Analytical Chemistry. 91, 15, s. 10188-10196

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Serine
Polymers
Peptides
Amino Acids, Peptides, and Proteins
Signal transduction
2018
78 Downloads (Pure)

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

Højfeldt, J. W., Laugesen, A., Willumsen, B. M., Damhofer, H., Hedehus, L., Tvardovskiy, A., Mohammad, F., Jensen, O. N. & Helin, K., 1. mar. 2018, I : Nature Structural and Molecular Biology. 25, 3, s. 225-232

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Epigenomics
Maintenance
Histones
Lysine
Mouse Embryonic Stem Cells
51 Downloads (Pure)

Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans

Kreher, J., Takasaki, T., Cockrum, C., Sidoli, S., Garcia, B. A., Jensen, O. N. & Strome, S., 1. nov. 2018, I : Genetics. 210, 3, s. 969-982

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Caenorhabditis elegans
Epigenomics
Embryonic Structures
Oocytes
Mothers

Elucidation of histone proteoform dynamics during aging by using middle-down mass spectrometry

Jensen, O. N., 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

83 Downloads (Pure)

Evaluation of sample preparation methods for mass spectrometry-based proteomic analysis of barley leaves

Wang, W. Q., Jensen, O. N., Møller, I. M., Hebelstrup, K. H. & Rogowska-Wrzesinska, A., 25. aug. 2018, I : Plant Methods. 14, 1, s. 1-13 72.

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proteomics
barley
mass spectrometry
digestion
deoxycholic acid
47 Downloads (Pure)

Extensive Characterization of Heavily Modified Histone Tails by 193 nm Ultraviolet Photodissociation Mass Spectrometry via a Middle-Down Strategy

Greer, S. M., Sidoli, S., Coradin, M., Schack Jespersen, M., Schwämmle, V., Jensen, O. N., Garcia, B. A. & Brodbelt, J. S., sep. 2018, I : Analytical Chemistry. 90, 17, s. 10425–10433

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Photodissociation
Histones
Mass spectrometry
Bioinformatics
Peptides
63 Downloads (Pure)

How many human proteoforms are there?

Aebersold, R., Agar, J. N., Amster, I. J., Baker, M. S., Bertozzi, C. R., Boja, E. S., Costello, C. E., Cravatt, B. F., Fenselau, C., Garcia, B. A., Ge, Y., Gunawardena, J., Hendrickson, R. C., Hergenrother, P. J., Huber, C. G., Ivanov, A. R., Jensen, O. N., Jewett, M. C., Kelleher, N. L., Kiessling, L. L. & 33 flere, Krogan, N. J., Larsen, M. R., Loo, J. A., Ogorzalek Loo, R. R., Lundberg, E., MacCoss, M. J., Mallick, P., Mootha, V. K., Mrksich, M., Muir, T. W., Patrie, S. M., Pesavento, J. J., Pitteri, S. J., Rodriguez, H., Saghatelian, A., Sandoval, W., Schlüter, H., Sechi, S., Slavoff, S. A., Smith, L. M., Snyder, M. P., Thomas, P. M., Uhlén, M., Van Eyk, J. E., Vidal, M., Walt, D. R., White, F. M., Williams, E. R., Wohlschlager, T., Wysocki, V. H., Yates, N. A., Young, N. L. & Zhang, B., 14. feb. 2018, I : Nature Chemical Biology. 14, 3, s. 206-214

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Proteins
Proteome
Databases
RNA
DNA
88 Downloads (Pure)

Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms

Garabedian, A., Baird, M. A., Porter, J., Jeanne Dit Fouque, K., Shliaha, P. V., Jensen, O. N., Williams, T. D., Fernandez-Lima, F. & Shvartsburg, A. A., 2018, I : Analytical Chemistry. 90, 4, s. 2918-2925

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Ions
Electrospray ionization
Ion sources
Proteome
Binary mixtures
38 Downloads (Pure)

Maximizing Sequence Coverage in Top-Down Proteomics By Automated Multi-modal Gas-phase Protein Fragmentation

Shliaha, P. V., Gibb, S., Gorshkov, V., Jespersen, M. S., Andersen, G. R., Bailey, D., Schwartz, J., Eliuk, S., Schwämmle, V. & Jensen, O. N., 25. sep. 2018, I : Analytical Chemistry. 90, 21, s. 12519-12526

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Gases
Proteins
Proteomics
Mass spectrometry
Amino Acids
53 Downloads (Pure)

Organic matter processing by microbial communities throughout the Atlantic water column as revealed by metaproteomics

Bergauer, K., Fernandez-Guerra, A., Garcia, J. A. L., Sprenger, R. R., Stepanauskas, R., Pachiadaki, M. G., Jensen, O. N. & Herndl, G. J., 16. jan. 2018, I : Proceedings of the National Academy of Sciences of the United States of America. 115, 3, s. E400-E408

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Archaeal Proteins
Heterotrophic Processes
Metagenomics
Particulate Matter
Proteins

Phosphoproteomics in Microbiology: Protocols for Studying Streptomyces coelicolor Differentiation

Manteca, A., Rioseras, B., Rogowska-Wrzesinska, A. & Jensen, O. N., 2018, Microbial Proteomics: Methods and Protocols. Becher, D. (red.). Humana Press, Bind 1841. s. 249-260 (Methods in Molecular Biology).

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Streptomyces coelicolor
Microbiology
53 Downloads (Pure)

Quantitative proteome and phosphoproteome analyses of Streptomyces coelicolor reveal proteins and phosphoproteins modulating differentiation and secondary metabolism

Rioseras, B., Sliaha, P. V., Gorshkov, V., Yagüe, P., López-García, M. T., González-Quiñónez, N., Kovalchuk, S., Rogowska-Wrzesinska, A., Jensen, O. N. & Manteca, A., 1. aug. 2018, I : Molecular and Cellular Proteomics. 17, 8, s. 1591-1611

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Streptomyces coelicolor
Secondary Metabolism
Phosphoproteins
Proteome
Phosphorylation

The tumor suppressor CIC directly regulates MAPK pathway genes via histone deacetylation

Weissmann, S., Cloos, P. A., Sidoli, S., Jensen, O. N., Pollard, S. & Helin, K., 2018, I : Cancer Research. 78, 15, s. 4114-4125

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Histones
Oligodendroglioma
Neoplasms
Histone Deacetylases
Amino Acid Substitution
22 Downloads (Pure)

VSClust: Feature-based variance-sensitive clustering of omics data

Schwämmle, V. & Jensen, O. N., sep. 2018, I : Bioinformatics. 34, 17, s. 2965–2972

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Cluster Analysis
Workflow
Proteins
2017

A biotin enrichment strategy identifies novel carbonylated amino acids in proteins from human plasma

Havelund, J. F., Wojdyla, K., Davies, M. J., Jensen, O. N., Møller, I. M. & Rogowska-Wrzesinska, A., 3. jan. 2017, I : Journal of Proteomics. 156, s. 40-51

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Plasma (human)
Biotin
Amino Acids
Protein Carbonylation
Carbonylation
132 Downloads (Pure)

Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment

Wang, W., Sidoli, S., Zhang, W., Wang, Q., Wang, L., Jensen, O. N., Guo, L., Zhao, X. & Zheng, L., 2017, I : Scientific Reports. 7, 14 s., 45103.

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Minocycline
Histones
Retina
Rodentia
Diabetic Retinopathy
150 Downloads (Pure)

Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape

Tvardovskiy, A., Schwämmle, V., Kempf, S. J., Rogowska-Wrzesinska, A. & Jensen, O. N., 2017, I : Nucleic Acids Research. 45, 16, s. 9272-9289

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Histones
Mammals
Hepatocytes
Cell Cycle
Protein Isoforms
103 Downloads (Pure)

Characterization of Complete Histone Tail Proteoforms Using Differential Ion Mobility Spectrometry

Shliaha, P. V., Baird, M. A., Nielsen, M. M., Gorshkov, V., Bowman, A. P., Kaszycki, J. L., Jensen, O. N. & Shvartsburg, A. A., 2017, I : Analytical Chemistry. 89, 10, s. 5461-5466

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Histones
Spectrometry
Ions
Acetylation
Phosphorylation

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

Mohammad, F., Weissmann, S., Leblanc, B., Pandey, D. P., Højfeldt, J. W., Comet, I., Zheng, C., Johansen, J. V., Rapin, N., Porse, B. T., Tvardovskiy, A., Jensen, O. N., Olaciregui, N. G., Lavarino, C., Suñol, M., De Torres, C., Mora, J., Carcaboso, A. M. & Helin, K., 2017, I : Nature Medicine. 23, 4, s. 483-492

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Pediatrics
Polycomb Repressive Complex 2
Glioma
Genes
Tumors
91 Downloads (Pure)

Hierarchically templated beads with tailored pore structure for phosphopeptide capture and phosphoproteomics

Wierzbicka, C., Torsetnes, S. B., Jensen, O. N., Shinde, S. & Sellergren, B., 2017, I : RSC Advances. 7, 28, s. 17154-17163 10 s.

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Phosphopeptides
Pore structure
Peptides
Phosphotyrosine
Silicon Dioxide

Molecularly Imprinted Porous Monolithic Materials from Melamine-Formaldehyde for Selective Trapping of Phosphopeptides

Liu, M., Tran, T. M., Abbas Elhaj, A. A., Bøen Torsetnes, S., Jensen, O. N., Sellergren, B. & Irgum, K., 2017, I : Analytical Chemistry. 89, 17, s. 9491-9501

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Phosphopeptides
Polyethers
Surface-Active Agents
Phosphoserine
Phosphotyrosine

Nuclear phosphoproteome analysis of 3T3-L1 preadipocyte differentiation reveals system-wide phosphorylation of transcriptional regulators

Rabiee, A., Schwämmle, V., Sidoli, S., Dai, J., Rogowska-Wrzesinska, A., Mandrup, S. & Jensen, O. N., 2017, I : Proteomics. 17, 6, 5 s., 1600248.

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Phosphorylation
Adipogenesis
Adipocytes
Gene expression
Nuclear Proteins
80 Downloads (Pure)

Phosphotyrosine biased enrichment of tryptic peptides from cancer cells by combining pY-MIP and TiO2 affinity resins

Bllaci, L., Torsetnes, S. B., Wierzbicka, C. K., Shinde, S., Sellergren, B., Rogowska-Wrzesinska, A. & Jensen, O. N., 2017, I : Analytical Chemistry. 89, 21, s. 11332–11340

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Phosphopeptides
Phosphotyrosine
Polymers
Resins
Cells
2016

Dynamic changes of histone H3 marks during Caenorhabditis elegans lifecycle revealed by middle-down proteomics

Sidoli, S., Vandamme, J., Salcini, A. E. & Jensen, O. N., 2016, I : Proteomics. 16, 3, s. 459–464

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Caenorhabditis elegans
Histones
Mammals
Protein Sequence Analysis
Tandem Mass Spectrometry

High-performance hybrid Orbitrap mass spectrometers for quantitative proteome analysis: Observations and implications

Williamson, J. C., Edwards, A. V. G., Verano-Braga, T., Schwämmle, V., Kjeldsen, F., Jensen, O. N. & Larsen, M. R., mar. 2016, I : Proteomics. 16, 6, s. 907-914

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Heat-Shock Response
Mass spectrometers
Proteome
Ions
Isotope Labeling
154 Downloads (Pure)

Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae

Yagüe, P., Willemse, J., Koning, R. I., Rioseras, B., López-García, M. T., Gonzalez-Quiñonez, N., Lopez-Iglesias, C., Shliaha, P. V., Rogowska-Wrzesinska, A., Koster, A. J., Jensen, O. N., van Wezel, G. P. & Manteca, Á., 2016, I : Nature Communications. 7, 12467, 11 s.

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Peptidoglycan
compartments
membranes
Membranes
Growth
260 Downloads (Pure)

Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation

Schwämmle, V., Sidoli, S., Ruminowicz, C., Wu, X., Lee, C-F., Helin, K. & Jensen, O. N., 2016, I : Molecular and Cellular Proteomics. 15, 8, s. 2715-2729

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Crosstalk
Histones
Chromatin
Methylation
Stem cells
2015

A laser ablation ICP-MS based method for multiplexed immunoblot analysis: applications to manganese-dependent protein dynamics of photosystem II in barley (Hordeum vulgare L.)

de Bang, T. C., Petersen, J., Pedas, P. R., Rogowska-Wrzesinska, A., Jensen, O. N., Schjoerring, J. K., Jensen, P. E., Thelen, J. J. & Husted, S., aug. 2015, I : Plant Journal. 83, 3, s. 555-65

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Photosystem II Protein Complex
Manganese
photosystem II
Hordeum vulgare
lasers

Detection and differentiation of 22kDa and 20kDa Growth Hormone proteoforms in human plasma by LC-MS/MS

Sanmartín, G. S., Bache, N., Bosch, J., Gutierrez-Gallego, R., Segura, J. & Jensen, O. N., 2015, I : B B A - Proteins and Proteomics. 1854, 4, s. 284-290

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113 Downloads (Pure)

H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans

Vandamme, J., Sidoli, S., Mariani, L., Friis, C., Christensen, J., Helin, K., Jensen, O. N. & Salcini, A. E., 2015, I : Nucleic Acids Research. 43, 20, s. 9694-9710

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Caenorhabditis elegans
Histones
Histone Demethylases
Chromatin Immunoprecipitation
Germ Cells

Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells

Zub, K. A., Sousa, M. M. L. D., Sarno, A., Sharma, A., Demirovic, A., Rao, S., Young, C., Aas, P. A., Ericsson, I., Sundan, A., Jensen, O. N. & Slupphaug, G., 2015, I : PLOS ONE. 10, 3, 20 s., e0119857.

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myeloma
Melphalan
Oxidative stress
Metabolic Networks and Pathways
biochemical pathways
658 Downloads (Pure)

NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer

Lund, R. R., Leth-Larsen, R., Caterino, T. D., Terp, M. G., Nissen, J., Lænkholm, A-V., Jensen, O. N. & Ditzel, H. J., nov. 2015, I : Molecular and Cellular Proteomics. 14, 11, s. 2988-99

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Cytochrome-B(5) Reductase
Cytochromes b5
Cytochrome Reductases
Estrogen Receptors
Disease-Free Survival

Quantitative analysis of proteome and lipidome dynamics reveals functional regulation of global lipid metabolism

Casanovas, A., Sprenger, R. R., Tarasov, K., Ruckerbauer, D. E., Hannibal-Bach, H. K., Zanghellini, J., Jensen, O. N. & Ejsing, C. S., 19. mar. 2015, I : Chemistry & Biology. 22, 3, s. 412-25 14 s.

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Proteome
Lipid Metabolism
Sterols
Metabolism
Chemical analysis

Targeted mass spectrometry analysis of the proteins IGF1, IGF2, IBP2, IBP3 and A2GL by blood protein precipitation

Such-Sanmartín, G., Bache, N., Callesen, A. K., Rogowska-Wrzesinska, A. & Jensen, O. N., 15. jan. 2015, I : Journal of Proteomics. 113, s. 29-37 9 s.

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Mass spectrometry
Blood Proteins
Biomarkers
Liquid chromatography
Liquid Chromatography

The human oral metaproteome reveals potential biomarkers for caries disease

Belda-Ferre, P., Williamson, J., Simón-Soro, Á., Artacho, A., Jensen, O. N. & Mira, A., okt. 2015, I : Proteomics. 15, 20, s. 3497-3507

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Biomarkers
Dental Plaque
Proteins
Bearings (structural)
Biofilms
158 Downloads (Pure)

Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns

Tvardovskiy, A., Wrzesinski, K., Sidoli, S., Fey, S. J., Rogowska-Wrzesinska, A. & Jensen, O. N., 30. sep. 2015, I : Molecular and Cellular Proteomics. 14, 12, s. 3142-3153

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Histones
Proteins
Hepatocytes
Mass spectrometry
Acetylation

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

Wu, X., Bekker-Jensen, I. H., Christensen, J., Rasmussen, K. D., Sidoli, S., Qi, Y., Kong, Y., Wang, X., Cui, Y., Xiao, Z., Xu, G., Williams, K., Rappsilber, J., Sønderby, C. K., Winther, O., Jensen, O. N. & Helin, K., 2015, I : Cell Research. 25, 11, s. 1205–1218

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Mutation
Histones
Transcriptional Activation
Lysine
Neoplasms

Two distinct modes for propagation of histone PTMs across the cell cycle

Alabert, C., Barth, T. K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O. N., Imhof, A. & Groth, A., 15. mar. 2015, I : Genes & Development. 29, 6, s. 585-90 6 s.

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Histones
Cell Cycle
Isotope Labeling
Epigenomics
Amino Acids
2014

Acute phencyclidine treatment induces extensive and distinct protein phosphorylation in rat frontal cortex

Palmowski, P., Rogowska-Wrzesinska, A., Williamson, J., Beck, H. C., Mikkelsen, J. D., Hansen, H. H. & Jensen, O. N., 7. mar. 2014, I : Journal of Proteome Research. 13, 3, s. 1578-1592 15 s.

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Phencyclidine
Phosphorylation
Rats
Proteins
Phosphopeptides

Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury

Zhao, X., Sidoli, S., Wang, L., Wang, W., Guo, L., Jensen, O. N. & Zheng, L., 4. apr. 2014, I : Journal of Proteome Research. 13, 4, s. 2175-86 12 s.

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Histones
Wounds and Injuries
Retina
Eye Diseases
Tandem Mass Spectrometry

Depletion of abundant plasma proteins by poly(N-isopropylacrylamide-acrylic acid) hydrogel particles

Such-Sanmartín, G., Ventura-Espejo, E. & Jensen, O. N., 4. feb. 2014, I : Analytical Chemistry. 86, 3, s. 1543-1550 8 s.

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Hydrogel
Blood Proteins
Mass spectrometry
Proteins
Biomarkers

FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine

Dikopoltsev, E., Foltyn, V. N., Zehl, M., Jensen, O. N., Mori, H., Radzishevsky, I. & Wolosker, H., 5. dec. 2014, I : Journal of Biological Chemistry. 289, 49, s. 33904-15

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Serine
Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Neurology

Global mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced endoplasmic reticulum stress

Carvalho, A. S., Ribeiro, H., Voabil, P., Penque, D., Jensen, O. N., Molina, H. & Matthiesen, R., dec. 2014, I : Molecular & Cellular Proteomics. 13, 12, s. 3294-307

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Endoplasmic Reticulum Stress
Glucosamine
Calnexin
Mass spectrometry
Pharmaceutical Preparations

Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo

Zhao, X., Bak, S., Pedersen, A. J. T., Jensen, O. N. & Højlund, K., 2. maj 2014, I : Journal of Proteome Research. 13, 5, s. 2359-69 11 s.

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Phosphorylation
Mitochondrial Proteins
Muscle
Skeletal Muscle
Insulin

Integrated Solid-Phase Extraction-Capillary Liquid Chromatography (speLC) Interfaced to ESI-MS/MS for Fast Characterization and Quantification of Protein and Proteomes

Falkenby, L. G., Such-Sanmartín, G., Larsen, M. R., Vorm, O., Bache, N. & Jensen, O. N., 2014, I : Journal of Proteome Research. 13, 12, s. 6169-75

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Solid Phase Extraction
Liquid chromatography
Proteome
Liquid Chromatography
Peptides

Isolation of Mitochondria from Potato Tubers

Havelund, J. F., Salvato, F., Chen, M., Rao, R. S. P., Rogowska-Wrzesinska, A., Jensen, O. N., Gang, D. R., Thelen, J. J. & Møller, I. M., 5. sep. 2014, I : Bio-protocol. 4, 17

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