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2017

CUDC-907 Promotes Bone Marrow Adipocytic Differentiation Through Inhibition of Histone Deacetylase and Regulation of Cell Cycle

Ali, D., Alshammari, H., Vishnubalaji, R., Chalisserry, E. P., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2017, I : Stem Cells and Development. 26, 5, s. 353-362

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Histone Deacetylases
Adipocytes
Cell Cycle
Mesenchymal Stromal Cells
Epigenomics

Effects of GIP, GLP-1 and GLP-1RAs on bone cell metabolism

Hansen, M. S., Tencerova, M., Frølich, J. S., Kassem, M. & Frost, M., 2017, I : Basic & Clinical Pharmacology & Toxicology.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Impact of Calcium and Two Doses of Vitamin D on Bone Metabolism in the Elderly: A Randomized Controlled Trial

Rahme, M., Sharara, S. L., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T., Bassil, D., El Ferkh, K. & El-Hajj Fuleihan, G., 2017, I : Journal of Bone and Mineral Research. 32, 7, s. 1486-1495

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Randomized Controlled Trials
Calcium Citrate
Hip
Body Mass Index

Legumain is a Novel Regulator of Bone Formation and Deregulated in Postmenopausal Osteoporosis

Jafari, A., Qanie, D. W. M., Levin Andersen, T., Chen, L., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaissé, J-M., Abdallah, B., Hesselson, D., Solberg, R. & Kassem, M., feb. 2017, I : Journal of Bone and Mineral Research. 31, S1, FR0152.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

231 Downloads (Pure)

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Levin Andersen, T., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., 2017, I : Stem Cell Reports. 8, 2, s. 373-386

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asparaginylendopeptidase
Postmenopausal Osteoporosis
Mesenchymal Stromal Cells
Bone
Osteoblasts
320 Downloads (Pure)

MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3

Elsafadi, M., Manikandan, M., Alajez, N. M., Hamam, R., Dawud, R. A., Aldahmash, A., Iqbal, Z., Alfayez, M., Kassem, M. & Mahmood, A., 2017, I : Stem Cell Research. 20, s. 94-104

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Lipoprotein Receptors
MicroRNAs
Mesenchymal Stromal Cells
Proteins
Clone Cells
255 Downloads (Pure)

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells

Elsafadi, M., Manikandan, M., Atteya, M., Abu Dawud, R., Almalki, S., Ali Kaimkhani, Z., Aldahmash, A., Alajez, N. M., Alfayez, M., Kassem, M. & Mahmood, A., 2017, I : Scientific Reports. 7, 15 s., 10797.

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Osteoblasts
Mesenchymal Stromal Cells
Adipocytes
Cell Differentiation
Fatty Acids
245 Downloads (Pure)

Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion

Slots, C., Bonde Jensen, M., Ditzel, N., Hedegaard, M. A. B., Borg, S. W., Albrektsen, O., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2017, I : Dental Materials. 33, 2, s. 198–208

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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3D printers
Ink
Extrusion
Suspensions
Phosphates

The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo

Bonde Jensen, M., Slots, C., Ditzel, N., Hedegaard, M. A. B., Andersen, T. E., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2. nov. 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

113 Downloads (Pure)

The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation

Bermeo, S., Al-Saedi, A., Kassem, M., Vidal, C. & Duque, G., 2017, I : Journal of Cellular Biochemistry. 118, 12, s. 4425–4435

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Nuclear Proteins
Mesenchymal Stromal Cells
Osteogenesis
Adipogenesis
Cell Differentiation
2016

Aging and bone

Gimble, J. M., Floyd, Z. E., Kassem, M. & Nuttall, M. E., 2016, Osteoporosis in Older Persons: Advances in Pathophysiology and Therapeutic Approaches. Duque, G. & Kiel, D. P. (red.). 2. udg. Springer, s. 23-42

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

273 Downloads (Pure)

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Vishnubalaji, R., Yue, S., Alfayez, M., Kassem, M., Liu, FF., Aldahmash, A. & Alajez, N. M., 2016, I : Cancer Cell International. 16, 12 s., 77.

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Colonic Neoplasms
Colorectal Neoplasms
Growth
SCID Mice
Computational Biology
92 Downloads (Pure)

CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

Harkness, L., Zaher, W., Ditzel, N., Isa, A. & Kassem, M., 2016, I : Stem Cell Research & Therapy. 7, 1, s. 4-16 13 s.

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Stem cells
Mesenchymal Stromal Cells
Bone
Population
Cells
570 Downloads (Pure)

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells

Elsafadi, M., Manikandan, M., Atteya, M., Hashmi, J. A., Iqbal, Z., Aldahmash, A., Alfayez, M., Kassem, M. & Mahmood, A., 2016, I : Stem Cells International. 2016, 18 s., 9378081.

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Mesenchymal Stromal Cells
Alkaline Phosphatase
Stromal Cells
Osteoblasts
Homeobox Genes
159 Downloads (Pure)

Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction

Wright, E. J., Hodson, N. W., Sherratt, M. J., Kassem, M., Lewis, A. L., Wallrapp, C., Malik, N. & Holt, C. M., 2016, I : Stem Cells International. 2016, 13 s., 7357096.

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Mesenchymal Stromal Cells
Apoptosis
Atomic Force Microscopy
Conditioned Culture Medium
Polymerase Chain Reaction
127 Downloads (Pure)

Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy

Aggerholm-Pedersen, N., Demouth, C., Safwat, A., Meldgaard, P., Kassem, M. & Sorensen, B. S., 2016, I : Stem Cells International. 2016, 8 s., 9601493.

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Sarcoma
Epidermal Growth Factor Receptor
Cell Survival
Cell Line
Transformed Cell Line
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Osteoblasts
Homeostasis
Luciferases
Osteogenesis
Osteoclasts

Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial

Fuleihan G, EI-H., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Rahme, M., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T. & Kassir, M-F., 2016, I : The American Journal of Clinical Nutrition. 104, 2, s. 315-323

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Insulin Resistance
Randomized Controlled Trials
Homeostasis
Calcium Citrate
Prediabetic State
117 Downloads (Pure)

Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases

Hotez, P. J. & Kassem, M., 2016, I : P L o S Neglected Tropical Diseases (Online). 10, 12, 4 s., e0005072.

Publikation: Bidrag til tidsskriftLederForskning

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117 Downloads (Pure)

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells

Ali, D., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2016, I : Stem Cells Translational Medicine. 5, 8, s. 1036-1047

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Mesenchymal Stromal Cells
Epigenomics
Stromal Cells
Libraries
Osteoblasts
137 Downloads (Pure)

Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

Morsing, M., Klitgaard, M. C., Jafari, A., Villadsen, R., Kassem, M., Petersen, O. W. & Rønnov-Jessen, L., 2016, I : Breast Cancer Research (Online). 18, s. 108

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Fibroblasts
Mesenchymal Stromal Cells
Morphogenesis
Stromal Cells
Growth

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

Wienken, M., Dickmanns, A., Nemajerova, A., Kramer, D., Najafova, Z., Weiss, M., Karpiuk, O., Kassem, M., zhang, Y., Lozano, G., Johnsen, S. A., Moll, U. M., Zhang, X. & Dobbelstein, M., 2016, I : Molecular Cell. 61, 1, s. 68-83

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Histones
Lysine
Ubiquitin-Protein Ligases
Oncogene Proteins
p53 Genes
144 Downloads (Pure)

MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1

Vishnubalaji, R., Hamam, R., Shijun, Y., AI-Obeed, O., Kassem, M., Liu, F-F., Aldahmash, A. & Alajez, N. M., 2016, I : Oncotarget. 7, 24, s. 35789–35802

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MicroRNAs
Colorectal Neoplasms
Neoplasms
SCID Mice
Fluorouracil
152 Downloads (Pure)

microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection

Hamam, R., Ali, A. M., Alsaleh, K. A., Kassem, M., Alfayez, M., Aldahmash, A. & Alajez, N. M., 2016, I : Scientific Reports. 2016, 8 s., 25997.

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MicroRNAs
Second Primary Neoplasms
Disease Management
Vacuum
Polymerase Chain Reaction

Neonatal High Bone Mass With First Mutation Of The NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65)

Frederiksen, A. L., Larsen, M. J., Brusgaard, K., Norvack, D. V., Knudsen, P. J. T., Schrøder, H. D., Qiu, W., Eckhardt, C., McAlister, W. H., Kassem, M., Mumm, S., Nielsen, M. F. M. & Whyte, M. P., 2016, I : Journal of Bone and Mineral Research. 31, 1, s. 163–172

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Osteopetrosis
Osteoclasts
Mutation
Osteoblasts
Fibroblasts

Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain of function mutations

Galan-Diez, M., Isa, A., Ponzetti, M., Nielsen, M. F. M., Kassem, M. & Kousteni, S., 2016, I : BBA General Subjects. 1863, 3, s. 490-8

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Study On Impact of Obesity On Cellular And Molecular Characteristics Of Bone Marrow Stromal Stem Cells In Healthy Men.

Tencerova, M., Frost, M., Nielsen, T. K. L. & Kassem, M., 2016.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

183 Downloads (Pure)

The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis

Tencerova, M. & Kassem, M., 2016, I : Frontiers in Endocrinology. 7, 12 s., 127.

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Adipogenesis
Mesenchymal Stromal Cells
Adipocytes
Cell Lineage
Osteoblasts
143 Downloads (Pure)

Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells

Twine, N. A., Harkness, L., Kassem, M. & Wilkins, M. R., 2016, I : BMC Genomics. 17, 15 s., 872.

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Osteoblasts
Small Interfering RNA
Up-Regulation
Nuclear Proteins
G-Protein-Coupled Receptors
131 Downloads (Pure)

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization

Elsafadi, E., Manikandan, M., Dawud, R. A., Alajez, N. M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Mahmood, A., 2016, I : Cell Death & Disease. 7, s. e2321 14 s.

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Actins
Cell Movement
Regenerative Medicine
Cell Proliferation
Focal Adhesions
100 Downloads (Pure)

Aarhus Regenerative Orthopaedics Symposium (AROS): Regeneration in the ageing population

Foldager, C. B., Bendtsen, M., Berg, L. C., Brinchmann, J. E., Brittberg, M., Bunger, C., Canseco, J., Chen, L., Christensen, B., Colombier, P., Deleuran, B. W., Edwards, J., Elmengaard, B., Farr, J., Gatenholm, B., Gomoll, A. H., Hui, J. H., Jakobsen, R. B., Jørgensen, N. L., Kassem, M. & 18 flere, Koch, T., Kold, S., Krogsgaard, M. R., Lauridsen, H., Le, D., Le Visage, C., Lind, M., Nygaard, J. V., Olesen, M. L., Pedersen, M., Rathcke, M. W., Richardson, J. B., Roberts, S., Rölfing, J. D., Sakai, D., Seong Toh, W., Urban, J. & Spector, M., 2016, I : Acta Orthopaedica (Print Edition). 87, s. 1-5

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2015

Anabolic compounds for treating and preventing bone loss diseases

Jafari, A., Chen, L., Kassem, M. & Abdallah, B., 7. maj 2015, Patentnr. WO2013167475 (A1), 7. maj 2015, Prioritetsdato 3. maj 2013, Prioritetsnr. US201314399726

Publikation: Patent

84 Downloads (Pure)

Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells

Andersen, R. K., Zaher, W., Larsen, K. H., Ditzel, N., Drews, K., wruck, W., Adjaye, J., Abdallah, B. & Kassem, M., 8. okt. 2015, I : Stem Cell Research & Therapy. 6, s. 196

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Mesenchymal Stromal Cells
Osteogenesis
Bone
Clone Cells
Platelet-Derived Growth Factor Receptors
181 Downloads (Pure)

CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells

Abdallah, B. M., Al-Shammary, A., Skagen, P., Abu Dawud, R., Adjaye, J., Aldahmash, A. & Kassem, M., 21. sep. 2015, I : Stem Cell Research. 15, 3, s. 449-458 10 s.

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Mesenchymal Stromal Cells
Osteoblasts
Population
Stromal Cells
Computational Biology
314 Downloads (Pure)

CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells

Al-toub, M., Vishnubalaji, R., Hamam, R., Kassem, M., Abdallah, B. & Alajez, N. M., 2015, I : Stem Cell Research & Therapy. 24, 6, s. 135

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Mitogen-Activated Protein Kinase Kinases
Stem cells
Mesenchymal Stromal Cells
Cells
Neoplasms

Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

Rumman, M., Dhawan, J. & Kassem, M., 2015, I : Stem Cells. 33, 10, s. 2903-12

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Cell Cycle
Homeostasis
Wounds and Injuries

DLK1 regulates whole body glucose metabolism: A negative feedback regulation of the osteocalcin-insulin loop

Abdallah, B., Ditzel, N., Laborda, J., Karsenty, G. & Kassem, M., 2015, I : Diabetes. 64, 9, s. 3069-3080

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Osteocalcin
Osteoblasts
Insulin
Energy Metabolism
Insulin Resistance

Electrospun PVA-PCL-HAB scaffold for Craniofacial Bone Regeneration

Prabha, R. D., Kraft, D. C., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M., 2015, I : Tissue Engineering. Part A. 21, S1, s. S58 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

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119 Downloads (Pure)

Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer

Vishnubalaji, R., Hamam, R., Abdulla, MH., Mohammed, MA., Kassem, M., Al-Obeed, O., Aldahmash, A. & Alajez, N., 22. jan. 2015, I : Cell Death & Disease. 6, e1614, s. 1-11 11 s., 25611389.

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MicroRNAs
Colorectal Neoplasms
Messenger RNA
Down-Regulation
Neoplasms

Human stromal stem cell therapy using gene-modified cells

Zaher, W. & Kassem, M., 2015, Somatic Genome Manipulation: Advances, Methods, and Applications. Li, X-Q., Donnelly, D. J. & Jensen, T. G. (red.). Springer, s. 105-121

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells

Sanz-Nogués, C., Horan, J., Thompson, K., Howard, L., Ryan, G. & Kassem, M., 2015, I : Journal of Biomedical Materials Research. Part A. 103, 11, s. 3676-3688

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Stem cells
Capsules
Cellulose
Sodium
Cells
230 Downloads (Pure)

Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells

Chen, L., Shi, K., Frary, C., Ditzel, N., Hu, H., Qiu, W. & Kassem, M., 2015, I : Stem Cell Research. 15, 2, s. 281-289

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Stromal Cells
Osteoblasts
Osteogenesis
Actins
Cell Differentiation

MicroRNAs as Regulators of Adipogenic Differentiation of Mesenchymal Stem Cells

Hamam, D., Ali, D., Kassem, M., Aldahmash, A. & Alajez, N. M., 2015, I : Stem Cells and Development. 24, 4, s. 417-425

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MicroRNAs
Mesenchymal Stromal Cells
Fats
Physiological Phenomena
Adipogenesis
106 Downloads (Pure)

Molecular characterisation of stromal populations derived from human embryonic stem cells: Similarities to immortalised bone marrow derived stromal stem cells

Harkness, L., Twine, N. A., Abu Dawud, R., Jafari, A., Aldahmash, A., Wilkins, M. R., Adjaye, J. & Kassem, M., 2015, I : Bone Reports. 3, s. 32-39

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75 Downloads (Pure)

Paolo Bianco (1955-2015)

Kassem, M. & Jakob, F., 2015, I : Stem Cell Research. 15, 3, s. 742 1 s.

Publikation: Bidrag til tidsskriftKommentar/debatFormidling

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Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling.

Jafari, A., Siersbæk, M., Chen, L., Qanie, D. W. M., Zaher, W., Abdallah, B. & Kassem, M., 2015, I : Stem Cells. 33, 7, s. 2219–2231

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Osteogenesis
Mesenchymal Stromal Cells
Osteoblasts
Adipogenesis

Proteomic Validation of Transcript Isoforms, Including Those Assembled from RNA-Seq Data

Tay, A. P., Pang, C. N. I., Twine, N. A., Hart-Smith, G., Harkness, L., Kassem, M. & Wilkins, M. R., 2015, I : Journal of Proteome Research. 14, 9, s. 3541-3554

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Protein Isoforms
RNA
Peptides
Databases
Genes

Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

Abdallah, B., Jafari, A., Zaher, W., Qiu, W. & Kassem, M., jan. 2015, I : Bone. 70, s. 28-36 9 s.

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Stromal Cells
Osteoblasts
Osteogenesis
Wnt Receptors
Chondrocytes

Skeletal stem cells in space and time

Kassem, M. & Bianco, P., 15. jan. 2015, I : Cell. 160, 1-2, s. 17-19 2 s.

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Stem cells
Tissue
Physiology
Maintenance

Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway

Saeed, H., Qiu, W., Chen, L., Flyvbjerg, A., Abdallah, B. & Kassem, M., 2015, I : Biogerontology. 16, 6, s. 733-745

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Telomerase
Osteoblasts
Osteogenesis
Alkaline Phosphatase
Stromal Cells