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2019

Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study

Frost, M., Tencerova, M., Andreasen, C. M., Levin Andersen, T., Ejersted, C. A., Svaneby, D., Kassem, M., Whyte, M. P. & Frederiksen, A. L., apr. 2019, I : Bone. 121, s. 243-254

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Osteopetrosis
Case-Control Studies
Mutation
Incontinentia Pigmenti
X Chromosome Inactivation

Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells

Nehlin, J. O., Jafari, A., Tencerova, M. & Kassem, M., 1. jun. 2019, I : Bone. 123, s. 265-273

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Stromal Cells
Adipocytes
Physiological Phenomena
Adiposity
Osteoblasts
97 Downloads (Pure)

A simple and reliable protocol for long-term culture of murine bone marrow stromal (mesenchymal) stem cells that retained their in vitro and in vivo stemness in long-term culture

Abdallah, B. M., Alzahrani, A. M., Abdel-Moneim, A. M., Ditzel, N. & Kassem, M., feb. 2019, I : Biological Procedures Online. 21, 11 s., 3.

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Mesenchymal Stromal Cells
Osteoblasts
Population
Fibroblast Growth Factor 2
Stromal Cells
Adipogenesis
Stem Cell Factor
Osteogenesis
Color
110 Downloads (Pure)

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation

El-Safadi, M., Shinwari, T., Al-Malki, S., Manikandan, M., Mahmood, A., Aldahmash, A., Alfayez, M., Kassem, M. & Alajez, N. M., 21. mar. 2019, I : Scientific Reports. 9, 13 s., 4977.

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Mesenchymal Stromal Cells
Cell Differentiation
Up-Regulation
Regenerative Medicine
Gene Expression Profiling
64 Downloads (Pure)

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors

Al-Toub, M., Almohawes, M., Vishnubalaji, R., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 2019, I : Cell Death Discovery. 5, 9 s., 87.

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Stem Cell Factor
Mesenchymal Stromal Cells
Neoplasms
Stromal Cells
Conditioned Culture Medium

Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease

Dige, A., Hougaard, H. T., Agnholt, J., Pedersen, B. G., Tencerova, M., Kassem, M., Krogh, K. & Lundby, L., 1. jun. 2019, I : Gastroenterology. 156, 8, s. 2208-2216.e1

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Crohn Disease
Adipose Tissue
Cutaneous Fistula
Lipectomy
Perineum

ESTABLISHMENT OF A KNOCKDOWN MODEL FOR UNRAVELLING THE PATHOGENESIS OF MANTLE CELL LYMPHOMA

Valentin Hansen, S., Cédile, O., Hansen, M. C., Christensen, J. H., Chen, L., Kassem, M., Abildgaard, N. & Nyvold, C. G., jun. 2019.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

Almuraikhi, N., Almasoud, N., Binhamdan, S., Younis, G., Ali, D., Manikandan, M., Vishnubalaji, R., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2019, I : Stem Cells International. 2019, 12 s., 3435901.

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Hedgehogs
Osteoblasts
Mesenchymal Stromal Cells
Osteogenesis
Gene Expression Profiling

Insulin Signaling in Bone Marrow Adipocytes

Tencerova, M., Okla, M. & Kassem, M., dec. 2019, I : Current Osteoporosis Reports. 17, 6, s. 446-454

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Adipocytes
Insulin
Fats
Cell Aging
Adiposity
86 Downloads (Pure)

KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment

Chen, L., Shi, K., Andersen, T. L., Qiu, W. & Kassem, M., 12. feb. 2019, I : Cell Death and Disease. 10, 2, s. 1-13 126.

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Cell Movement
Osteogenesis
Actins
CD44 Antigens
Stromal Cells

Lansoprazole inhibits the cysteine protease legumain by binding to the active site

Bosnjak, T., Solberg, R., Hemati, P. D., Jafari, A., Kassem, M. & Johansen, H. T., aug. 2019, I : Basic & Clinical Pharmacology & Toxicology. 125, 2, s. 89-99

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asparaginylendopeptidase
Lansoprazole
Cysteine Proteases
Proton Pump Inhibitors
Catalytic Domain

Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation

Falster, C., Poulsen, S. S., Storaas, A. M., Schroeder, H. M., Vinther, J. H., Kassem, M. & Joergensen, U., 1. sep. 2019, I : Journal of Orthopaedic Science. 24, 5, s. 918-924

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Knee Osteoarthritis
Mesenchymal Stromal Cells
Osteogenesis
Wounds and Injuries
Knee
19 Downloads (Pure)

Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

Tencerova, M., Rendina-Ruedy, E., Neess, D., Færgeman, N., Figeac, F., Ali, D., Danielsen, M., Haakonsson, A., Rosen, C. J. & Kassem, M., 1. dec. 2019, I : Bone Research. 7, 14 s., 35.

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Mesenchymal Stromal Cells
Adipocytes
Oxidative Phosphorylation
Insulin
Osteoblasts
78 Downloads (Pure)

Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B

Vishnubalaji, R., Elango, R., Al-Toub, M., Manikandan, M., Al-Rikabi, A., Harkness, L., Ditzel, N., Atteya, M., Hamam, R., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 1. dec. 2019, I : Scientific Reports. 9, 14 s., 8101.

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Mesenchymal Stromal Cells
Sarcoma
Linear Energy Transfer
Mesoderm
Osteoblasts
48 Downloads (Pure)

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

Almuraikhi, N., Ali, D., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 22. aug. 2019, I : Stem Cells International. 2019, 13 s., 3041262.

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Osteoblasts
Mesenchymal Stromal Cells
Osteogenesis
Gene Expression Profiling
Alkaline Phosphatase
106 Downloads (Pure)
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Stem cells
Mesenchymal Stromal Cells
Bone
Insulin
RNA Sequence Analysis

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

Rauch, A., Haakonsson, A. K., Madsen, J. G. S., Larsen, M., Forss, I., Madsen, M. R., Van Hauwaert, E. L., Wiwie, C., Jespersen, N. Z., Tencerova, M., Nielsen, R., Larsen, B. D., Röttger, R., Baumbach, J., Scheele, C., Kassem, M. & Mandrup, S., apr. 2019, I : Nature Genetics. 51, 4, s. 716-727

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Adipogenesis
Stem Cell Factor
Mesenchymal Stromal Cells
Osteogenesis
Chromatin Assembly and Disassembly
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Mesenchymal Stromal Cells
Osteoblasts
Translational Medical Research
Adipocytes
Osteogenesis

Strontium functionalized scaffold for bone tissue engineering

Prabha, R. D., Nair, B. P., Ditzel, N., Kjems, J., Nair, P. D. & Kassem, M., 1. jan. 2019, I : Materials Science and Engineering C: Biomimetic Materials, Sensors and Systems. 94, s. 509-515

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strontium ranelate
Tissue Engineering
Stromal Cells
Growth
Dentistry
58 Downloads (Pure)

TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling

Jafari, A., Isa, A., Chen, L., Ditzel, N., Zaher, W., Harkness, L., Johnsen, H. E., Abdallah, B. M., Clausen, C. & Kassem, M., 1. mar. 2019, I : Stem Cells. 37, 3, s. 407-416

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Stromal Cells
Mesenchymal Stromal Cells
Cell Movement
Closed Fractures
Pseudopodia
40 Downloads (Pure)

Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Walker, J. V., Zhuang, H., Singer, D., Illsley, C. S., Kok, W. L., Sivaraj, K. K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P. R. C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., Yang, K. & 7 flere, Bai, Y., Tredwin, C., Zambon, A. C., Corbeil, D., Adams, R., Abdallah, B. M. & Hu, B., 9. aug. 2019, I : Nature Communications. 10, 1, 18 s., 3596.

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stem cells
Incisor
transit
Stem cells
Mesenchymal Stromal Cells
2018
169 Downloads (Pure)

Actin depolymerization enhances adipogenic differentiation in human stromal stem cells

Chen, L., Hu, H., Qiu, W., Shi, K. & Kassem, M., 1. maj 2018, I : Stem Cell Research. 29, s. 76-83

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Stromal Cells
Adipocytes
Actins
Phalloidine
Cytochalasin D
131 Downloads (Pure)

Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice

Figeac, F., Andersen, D. C., Nipper Nielsen, C. A., Ditzel, N., Sheikh, S. P., Skjødt, K., Kassem, M., Jensen, C. H. & Abdallah, B. M., maj 2018, I : Bone. 110, s. 312-320

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Estrogens
Osteogenesis
Serum
X-Ray Microtomography
Adipogenesis
83 Downloads (Pure)

Bioactive Nano-fibrous Scaffold for Vascularized Craniofacial Bone Regeneration

Prabha, R. D., Kraft, D. C. E., Harkness, L., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M., mar. 2018, I : Journal of Tissue Engineering and Regenerative Medicine. 12, 3, s. e1537-e1548

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Polyvinyl Alcohol
Bioceramics
Durapatite
Scaffolds
Polyvinyl alcohols
95 Downloads (Pure)

Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report

Byberg, S., Abrahamsen, B., Kassem, M., Ralston, S. & Schwarz, P., 27. sep. 2018, I : Journal of Medical Case Reports. 12, 6 s., 278.

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Melorheostosis
zoledronic acid
113 Downloads (Pure)

Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

Schmal, H., Kowal, J. M., Kassem, M., Seidenstuecker, M., Bernstein, A., Böttiger, K., Xiong, T., Südkamp, N. P. & Kubosch, E. J., 1. jan. 2018, I : Stem Cells International. 2018, 12 s., 4142031.

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Chondrocytes
Rabbits
Collagen Type X
Collagen Type II
Collagen Type I

Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals

Bonde Jensen, M., Slots, C., Ditzel, N., Albrektsen, O., Wiatr Borg, S., Thygesen, T., Kassem, M. & Andersen, M. Ø., jun. 2018, I : Bioprinting. 10, e00027.

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Fatty acids
Biomaterials
Powders
Drug products
Fatty Acids
15 Downloads (Pure)
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Gastric Inhibitory Polypeptide
Glucagon-Like Peptide 1
Metabolism
Bone
Incretins
98 Downloads (Pure)

Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration

Chang, C-C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M. & Kjems, J., 7. feb. 2018, I : Molecular Therapy. 26, 2, s. 593-605

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MicroRNAs
Mesenchymal Stromal Cells
Osteoblasts
Osteogenesis
Cell Cycle
137 Downloads (Pure)

High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice

Tencerova, M., Figeac, F., Ditzel, N., Taipaleenmäki, H., Nielsen, T. K. & Kassem, M., jun. 2018, I : Journal of Bone and Mineral Research. 33, 6, s. 1154-1165

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High Fat Diet
Adipose Tissue
Adiposity
Insulin
Adipocytes
109 Downloads (Pure)

Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics

Rumman, M., Majumder, A., Harkness, L., Venugopal, B., Vinay, M. B., Pillai, M. S., Kassem, M. & Dhawan, J., jul. 2018, I : Stem Cell Research. 30, s. 69-80

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Mesenchymal Stromal Cells
Osteogenesis
Autocrine Communication
Paracrine Communication
cdc Genes

International Harmonization and Standardization between Denmark and Germany: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Wendlandt, R., Kowal, J. M., Haakonsson, A. K., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H., Frahm, T., Eckers, A. & 5 flere, Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 31. jul. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Leif Mosekilde IN MEMORIAM

Rejnmark, L., Brixen, K., Kassem, M., Hermann, P., Vestergaard, P., Eriksen, E. F., Bollerslev, J., Nielsen, H. K., Charles, P. & Langdahl, B., nov. 2018, I : Journal of Bone and Mineral Research. 33, 11, 1 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

93 Downloads (Pure)

Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses

Twine, N. A., Harkness, L., Adjaye, J., Aldahmash, A., Wilkins, M. R. & Kassem, M., sep. 2018, I : JBMR Plus. 2, 5, s. 257-267

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Mesenchymal Stromal Cells
Maintenance
Cell Aging
Osteoblasts
Cell Cycle
159 Downloads (Pure)

Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress prosurvival signalling pathways

Vishnubalaji, R., Manikandan, M., Fahad, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2. mar. 2018, I : OncoTarget. 9, 17, s. 13551-13564

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Colorectal Neoplasms
Neoplasms
aldehyde dehydrogenase 1
Fluorouracil
Disease-Free Survival
110 Downloads (Pure)

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells

Ayesh Hafez Ali, D., Abuelreich, S., Alkeraishan, N., Shwish, N. B., Hamam, R., Kassem, M., Alfayez, M., Aldahmash, A. & Alajez, N. M., 30. jan. 2018, I : Bioscience Reports. 38, 1, 10 s., BSR20171252.

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Stem cells
Mesenchymal Stromal Cells
Adipocytes
Bone
Metabolism
53 Downloads (Pure)

NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC

Manikandan, M., Abuelreich, S., Elsafadi, M., Alsalman, H., Almalak, H., Siyal, A., Hashmi, J. A., Aldahmash, A., Kassem, M., Alfayez, M. & Mahmood, A., 1. nov. 2018, I : Differentiation. 104, s. 36-41

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Osteoblasts
Down-Regulation
Cytoplasmic and Nuclear Receptors
Osteogenesis
Small Interfering RNA
86 Downloads (Pure)

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity

Ali, D., Chalisserry, E. P., Manikandan, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2018, I : Stem Cells International. 2018, 12 s., 2379546.

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Mesenchymal Stromal Cells
Epigenomics
Adipogenesis
Osteoblasts
Adipocytes
110 Downloads (Pure)

Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

Abdallah, B., Alzahrani, A. M. & Kassem, M., maj 2018, I : Bone. 110, s. 221-229

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Clusterin
MAP Kinase Signaling System
Osteoblasts
Mesenchymal Stromal Cells
Adipocytes
101 Downloads (Pure)

Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells

AlMuraikhi, N., Ali, D., Alshanwani, A., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2018, I : Stem Cell Research & Therapy. 9, 10 s., 319.

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Osteoblasts
Stem cells
Bone
Osteogenesis
Bioinformatics
116 Downloads (Pure)

TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

Elsafadi, M., Manikandan, M., Almalki, S., Mobarak, M., Atteya, M., Iqbal, Z., Hashmi, J. A., Shaheen, S., Alajez, N., Alfayez, M., Kassem, M., Dawud, R. A. & Mahmood, A., 2018, I : Stem Cells International. 2018, 14 s., 6913594.

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Cytochalasin D
Adipogenesis
Gene Expression Profiling
Computational Biology
Transcriptome
2017

Bone and Skeletal Stem Cells are Affected in High Fat Diet Mice

Figeac, F., Tencerova, M., Ditzel, N., Nielsen, T. K. L., Jørgensen, B. & Kassem, M., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D. V., Whyte, M. P. & Frederiksen, A. L., dec. 2017, I : Journal of Bone and Mineral Research. 32, S1, s. S395 1 s., MO0710.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D., Whyte, M. P. & Frederiksen, A. L., 2017.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

157 Downloads (Pure)

CHD1 regulates cell fate determination by activation of differentiation-induced genes

Baumgart, S. J., Najafova, Z., Hossan, T., Xie, W., Nagarajan, S., Kari, V., Ditzel, N., Kassem, M. & Johnsen, S. A., 2017, I : Nucleic Acids Research. 45, 13, s. 7722-7735

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DNA-Binding Proteins
Osteoblasts
Nucleosomes
RNA Polymerase II
Osteogenesis
90 Downloads (Pure)

Chromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cells

Burns, J. S., Harkness, L., Aldahmash, A., Gautier, L. & Kassem, M., 2017, I : Stem Cell Research. 25, s. 6-17

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Mesenchymal Stromal Cells
Diploidy
Comparative Genomic Hybridization
Cell Cycle Checkpoints
Computational Biology
158 Downloads (Pure)

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M., Zaher, W., Alfayez, M., Aldahmash, A. & Alajez, N. M., 7. sep. 2017, I : Cell Death & Disease. 8, 9, 12 s., e3045.

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MicroRNAs
Physiologic Monitoring
Nucleic Acids
Messenger RNA
DNA

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling

Abdallah, B. M., Figeac, F., Larsen, K. H., Ditzel, N., Keshari, P., Isa, A., Jafari, A., Andersen, T. L., Delaisse, J. M., Goshima, Y., Ohshima, T. & Kassem, M., maj 2017, I : Journal of Bone and Mineral Research. 32, 5, s. 913-926

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Osteoblasts
Osteogenesis
Proteins
Mesenchymal Stromal Cells
Cyclin D1

Cross-border biobanking: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Waizner, K., Wendlandt, R., Zweig, W., Kowal, J. M., Haakonsson, A., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H. & 12 flere, Duckert, R., Kroeger, I., Stueck, G., Kessel, S., Hecht, M., Frahm, T., Eckers, A., Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review