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2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals

Lifelines Cohort Study & V. A. Million Veteran Program, 1. jun. 2019, I : Nature Genetics. 51, 6, s. 957-972

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Kidney
Glomerular Filtration Rate
Translational Medical Research
Genome-Wide Association Study
Meta-Analysis
40 Downloads (Pure)

A Cohort Comparison of Lifespan After Age 100 in Denmark and Sweden: Are Only the Oldest Getting Older?

Medford, A., Christensen, K., Skytthe, A. & Vaupel, J. W., apr. 2019, I : Demography. 56, 2, s. 665-677

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life-span
Denmark
Swede
Sweden
trend
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Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies

Mengel-From, J., Svane, A. M., Pertoldi, C., Kristensen, T. N., Loeschcke, V., Skytthe, A., Christensen, K., Lindahl-Jacobsen, R., Hjelmborg, J. & Christiansen, L., 13. nov. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 12, s. 1853-1860

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Fruit
Parents
Maternal Age
Health
Drosophila melanogaster
34 Downloads (Pure)

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., 2019, I : Aging Cell. 8 s.

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DNA Methylation
Epigenomics
Sex Characteristics
38 Downloads (Pure)

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N. & 64 flere, Becker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J. F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L. P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J. M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., 1. dec. 2019, I : Nature Communications. 10, 1, 14 s., 3669.

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genome
Genome-Wide Association Study
genes
Meta-Analysis
Genes
54 Downloads (Pure)

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sørensen, T. I. A. & DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), aug. 2019, I : Acta Neuropathologica. 138, 2, s. 237-250

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Lewy Body Disease
Alzheimer Disease
Mutation
Neurodegenerative Diseases
Alleles

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity

Long Life Family Study, 2019, I : Metabolism: Clinical and Experimental. 94, s. 28-38

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Lung
Cognition
Fasting
Insulin
Metabolic Networks and Pathways

APOE Alleles and Extreme Human Longevity

Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., Andersen, S. L., Villa, F., Atzmon, G., Christensen, K., Arai, Y., Barzilai, N., Puca, A., Christiansen, L., Hirose, N. & Perls, T. T., 1. jan. 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 1, s. 44–51

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Alleles
Population
New England
Retirement
Genetic Models

Association of low-frequency genetic variants in regulatory regions with nonsyndromic orofacial clefts

Shaffer, J. R., LeClair, J., Carlson, J. C., Feingold, E., Buxó, C. J., Christensen, K., Deleyiannis, F. W. B., Field, L. L., Hecht, J. T., Moreno, L., Orioli, I. M., Padilla, C., Vieira, A. R., Wehby, G. L., Murray, J. C., Weinberg, S. M., Marazita, M. L. & Leslie, E. J., 1. mar. 2019, I : American Journal of Medical Genetics, Part A. 179, 3, s. 467-474

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Nucleic Acid Regulatory Sequences
Cleft Palate
Cleft Lip
Alleles
Cell Line
34 Downloads (Pure)

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 flere, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3. jan. 2019, I : American Journal of Human Genetics. 104, 1, s. 112-138

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Mitochondrial Genes
Body Mass Index
Insulin
Adipocytes
Type 2 Diabetes Mellitus

A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals

Carlson, J. C., Anand, D., Butali, A., Buxo, C. J., Christensen, K., Deleyiannis, F., Hecht, J. T., Moreno, L. M., Orioli, I. M., Padilla, C., Shaffer, J. R., Vieira, A. R., Wehby, G. L., Weinberg, S. M., Murray, J. C., Beaty, T. H., Saadi, I., Lachke, S. A., Marazita, M. L., Feingold, E. & 1 flere, Leslie, E. J., sep. 2019, I : Genetic Epidemiology. 43, 6, s. 704-716

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Genome-Wide Association Study
Cleft Palate
Cleft Lip

Cancer Incidence and Mortality in 260,000 Nordic Twins With 30,000 Prospective Cancers

Skytthe, A., Harris, J. R., Czene, K., Mucci, L., Adami, H-O., Christensen, K., Hjelmborg, J., Holm, N. V., Nilsen, T. S., Kaprio, J. & Pukkala, E., apr. 2019, I : Twin Research and Human Genetics. 22, 2, s. 99-107

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Confidence Intervals
Incidence
Neoplasms
Population
Registries

Clonal hematopoiesis in elderly twins: concordance, discordance and mortality

Hansen, J. W., Pedersen, D. A., Larsen, L. A., Husby, S., Clemmensen, S. B., Hjelmborg, J., Favero, F., Weischenfeldt, J., Christensen, K. & Grønbæk, K., 24. okt. 2019, I : Blood.

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Mutation
Twin Studies
Dizygotic Twins
Monozygotic Twins
Mutation Rate

Declining cancer incidence at the oldest ages: Hallmark of aging or lower diagnostic activity?

Pedersen, J. K., Rosholm, J-U., Ewertz, M., Engholm, G., Lindahl-Jacobsen, R. & Christensen, K., sep. 2019, I : Journal of Geriatric Oncology. 10, 5, s. 792-798

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Incidence
Neoplasms
Skin Neoplasms
Denmark
Colon

Deletions and loss-of-function variants in TP63 associated with orofacial clefting

Khandelwal, K. D., van den Boogaard, M-J. H., Mehrem, S. L., Gebel, J., Fagerberg, C., van Beusekom, E., van Binsbergen, E., Topaloglu, O., Steehouwer, M., Gilissen, C., Ishorst, N., van Rooij, I. A. L. M., Roeleveld, N., Christensen, K., Schoenaers, J., Bergé, S., Murray, J. C., Hens, G., Devriendt, K., Ludwig, K. U. & 6 flere, Mangold, E., Hoischen, A., Zhou, H., Dötsch, V., Carels, C. E. L. & van Bokhoven, H., jul. 2019, I : European Journal of Human Genetics. 27, 7, s. 1101-1112

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Alleles
Population Control
Penetrance
Nonsense Codon
Mutant Proteins
11 Downloads (Pure)

Diagnosing heart failure in centenarians

Rasmussen, S. H., Andersen-Ranberg, K., Dahl, J., Nybo, M., Jeune, B., Christensen, K. & Gill, S., 1. jan. 2019, I : Journal of Geriatric Cardiology. 16, 1, s. 1-11

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Brain Natriuretic Peptide
Echocardiography
Population
Denmark
Left Ventricular Function
82 Downloads (Pure)

DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

Lund, J., Li, S., Baumbach, J., Svane, A. M., Hjelmborg, J. V. B., Christiansen, L., Christensen, K., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 8. feb. 2019, I : Clinical Epigenetics. 11, 8 s., 23.

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DNA Methylation
Genome-Wide Association Study
Survival Analysis
Proportional Hazards Models
Epigenomics
107 Downloads (Pure)

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins

Starnawska, A., Tan, Q., Sørensen, M., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2. sep. 2019, I : Translational Psychiatry. 9, 1, 14 s., 214.

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Monozygotic Twins
Depression
DNA Methylation
Epigenomics
Flow Cytometry
91 Downloads (Pure)

Epigenome-wide association study of leukocyte telomere length

Lee, Y., Sun, D., Ori, A. P. S., Lu, A. T., Seeboth, A., Harris, S. E., Deary, I. J., Marioni, R. E., Soerensen, M., Mengel-From, J., Hjelmborg, J., Christensen, K., Wilson, J. G., Levy, D., Reiner, A. P., Chen, W., Li, S., Harris, J. R., Magnus, P., Aviv, A. & 2 flere, Jugessur, A. & Horvath, S., 26. aug. 2019, I : Aging. 11, 16, s. 5876-5894

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Telomere
Epigenomics
Women's Health
DNA Methylation
Circadian Rhythm
42 Downloads (Pure)
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Fil
Monozygotic Twins
Cell Differentiation
HLA-C Antigens
Comb and Wattles
Nucleic Acid Regulatory Sequences

Gender differences in cognitive function and grip strength: a cross-national comparison of four European regions

Ahrenfeldt, L. J., Scheel-Hincke, L. L., Kjærgaard, S., Möller, S., Christensen, K. & Lindahl-Jacobsen, R., 1. aug. 2019, I : European Journal of Public Health. 29, 4, s. 667-674

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Cognition
Sex Characteristics
Linear Models
Health
Retirement

Gene-lifestyle interactions in longevity

Lindahl-Jacobsen, R. & Christensen, K., 2019, Cambridge Handbook of Successful Aging. Fernández-Ballesteros, R., Benetos, A. & Robine, J-M. (red.). New York: Cambridge University Press, s. 91-109

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition

Hearing loss, cognitive ability, and dementia in men age 19–78 years

Osler, M., Christensen, G. T., Mortensen, E. L., Christensen, K., Garde, E. & Rozing, M. P., feb. 2019, I : European Journal of Epidemiology. 34, 2, s. 125-130

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International Classification of Diseases
Registries
Depression
Physicians
Education

Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism

for the Long Life Family Study, aug. 2019, I : GeroScience. 41, 4, s. 383-393

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Lung
Fasting
Body Mass Index
Insulin
Lipids

Hver anden nyfødt bliver 100 år: Levealderen fortsætter med at stige

Christensen, K., feb. 2019, Det gode liv: Fynske opskrifter til seniorlivet. Fyens Stiftstidende

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiFormidling

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79 Downloads (Pure)

Independent associations of TOMM40 and APOE variants with body mass index

Long Life Family Study Research Group, 1. feb. 2019, I : Aging Cell. 18, 1, 10 s., e12869.

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Body Mass Index
Alleles
Heterozygote
Alzheimer Disease
Confidence Intervals
56 Downloads (Pure)

Is the age difference between partners related to women's earnings?

Corollo, A., Oksuzyan, A., Drefahl, S., Camarda, C. G., Juel Ahrenfeldt, L., Christensen, K. & van Raalte, A., jul. 2019, I : Demographic Research. 41, s. 425-460 15.

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age difference
income
Denmark
husband
career
Åben adgang
Fil
Proxy
Longitudinal Studies
Registries
Cohort Studies
Surveys and Questionnaires
69 Downloads (Pure)

Lifespans of Twins: Does Zygosity Matter?

Hjelmborg, J., Larsen, P. V., Kaprio, J., McGue, M., Scheike, T., Hougaard, P. & Christensen, K., feb. 2019, I : Genes. 10, 2, 10 s., E166.

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Dizygotic Twins
Monozygotic Twins
Twin Studies
Liver
Survival Analysis

Longitudinal Associations of Sensory and Cognitive Functioning: A Structural Equation Modeling Approach

de la Fuente, J., Hjelmborg, J., Wod, M., de la Torre-Luque, A., Caballero, F. F., Christensen, K. & Ayuso-Mateos, J. L., 4. okt. 2019, I : Journals of Gerontology. Series B: Psychological Sciences & Social Sciences. 74, 8, s. 1308-1316

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visual impairment
hearing impairment
old age
Hearing
cognition
65 Downloads (Pure)

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts

Jylhävä, J., Hjelmborg, J., Sørensen, M., Munoz, E., Tan, Q., Kuja-Halkola, R., Mengel-From, J., Christensen, K., Christiansen, L., Hägg, S., Pedersen, N. L. & Reynolds, C. A., feb. 2019, I : EBioMedicine. 40, s. 710-716

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Epigenomics
Clocks
Research
DNA Methylation
Epidemiology
29 Downloads (Pure)

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Understanding Society Scientific Group, Lifelines Cohort, COGENT-Kidney Consortium & EPIC-InterAct Consortium, apr. 2019, I : Nature Genetics. 51, 4, s. 636-648

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Smoking
Lipids
Serum
LDL Cholesterol
Meta-Analysis
Life Expectancy
Health
Population

Prevalence, Incidence and Risk Factors for Overall, Physical and Cognitive Independence among those from exceptionally long-lived families: The Long Life Family Study

Santanasto, A. J., Marron, M. M., Boudreau, R. M., Feitosa, M. F., Wojczynski, M. K., Arbeev, K. G., Thyagarajan, B., Schupf, N., Stallard, E., Sebastiani, P., Cosentino, S., Christensen, K. & Newman, A. B., 14. maj 2019, I : The journals of gerontology. Series A, Biological sciences and medical sciences.

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Survivors
Incidence
Lung
Neoplasms
Advanced Glycosylation End Product-Specific Receptor

Resting heart rate and mortality in the very old

Wod, M., Jensen, M. T., Galatius, S., Hjelmborg, J. B., Jensen, G. B. & Christensen, K., dec. 2019, I : Scandinavian Journal of Clinical & Laboratory Investigation. 79, 8, s. 566-571

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Population
Palpation
Survival Analysis
Proportional Hazards Models
Cohort Studies

Sex Differences in Comorbidity and Frailty in Europe

Ahrenfeldt, L. J., Möller, S., Thinggaard, M., Christensen, K. & Lindahl-Jacobsen, R., sep. 2019, I : International Journal of Public Health. 64, 7, s. 1025-1036

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Sex Characteristics
Comorbidity
Retirement
Health Surveys
Cross-Sectional Studies
40 Downloads (Pure)

The AgeGuess database, an open online resource on chronological and perceived ages of people aged 5-100

Jones, J. A. B., Nash, U. W., Vieillefont, J., Christensen, K., Misevic, D. & Steiner, U. K., 31. okt. 2019, I : Scientific Data. 6, 8 s., 246.

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Aging of materials
Resources
Biomarkers
resources
Guess

The association between depressive mood and ischemic heart disease: a twin study

Wium-Andersen, M. K., Wium-Andersen, I. K., Jørgensen, M. B., McGue, M., Jørgensen, T. S. H., Christensen, K. & Osler, M., sep. 2019, I : Acta Psychiatrica Scandinavica. 140, 3, s. 265-274

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Twin Studies
Depression
Social Adjustment
Dizygotic Twins
Monozygotic Twins
Registries
Twin Studies
Denmark

The Guinea-Bissau Twin Registry Update: A Platform for Studying Twin Mortality and Metabolic Disease

Bariatri og Diabetes, 18. jul. 2019, I : Twin Research and Human Genetics. s. 1-7 7 s.

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Guinea-Bissau
Metabolic Diseases
Registries
Africa South of the Sahara
Twin Studies

Use of β2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease

Hopfner, F., Wod, M., Höglinger, G. U., Blaabjerg, M., Rösler, T. W., Kuhlenbäumer, G., Christensen, K., Deuschl, G. & Pottegård, A., 9. jul. 2019, I : Neurology. 93, 2, s. e135-e142

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Parkinson Disease
Pharmaceutical Preparations
Odds Ratio
Confidence Intervals
Chronic Obstructive Pulmonary Disease
2018

A bidirectional association between cognitive ability in young adulthood and epilepsy: a population-based cohort study

Osler, M., Mortensen, E. L., Christensen, K. & Christensen, G. T., 1. aug. 2018, I : International Journal of Epidemiology. 47, 4, s. 1151–1158

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Cohort Studies
Population
International Classification of Diseases
Registries
Databases

A Cross-National Study of the Gender Gap in Health Among Older Adults in India and China: Similarities and Disparities

Oksuzyan, A., Singh, P. K., Christensen, K. & Jasilionis, D., 3. nov. 2018, I : The Gerontologist. 58, 6, s. 1156–1165

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China
Health
Confidence Intervals
Cognition
Logistic Models

Age-moderation of genetic and environmental contributions to cognitive functioning in mid- and late-life for specific cognitive abilities

Pahlen, S., Hamdi, N. R., Dahl Aslan, A. K., Horwitz, B. N., Panizzon, M. S., Petersen, I., Zavala, C., Christensen, K., Finkel, D., Franz, C. E., Gatz, M., Johnson, W., Kremen, W. S., Krueger, R. F., Neiderhiser, J. M., Reynolds, C. A., Pedersen, N. L. & McGue, M., 1. maj 2018, I : Intelligence. 68, s. 70-81

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Vocabulary
Denmark
Age Groups
Moderation
Cognitive Ability

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

CHARGE Neurology Working Group, 1. mar. 2018, I : American Journal of Human Genetics. 102, 3, s. 375-400

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Smoking
Genome-Wide Association Study
Meta-Analysis
Telomere
Single Nucleotide Polymorphism
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A novel healthy blood pressure phenotype in the Long Life Family Study

Marron, M. M., Singh, J., Boudreau, R. M., Christensen, K., Cosentino, S., Feitosa, M. F., Minster, R. L., Perls, T., Schupf, N., Sebastiani, P., Ukraintseva, S., Wojczynski, M. K. & Newman, A. B., 2018, I : Journal of Hypertension. 36, 1, s. 43-53

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Fil
Neuropsychological Tests
Executive Function
Cohort Studies
Smoking
Health

Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies

Christensen, K. & TELOMAAS group, 1. sep. 2018, I : American Journal of Clinical Nutrition. 108, 3, s. 453-475

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Telomere
Meta-Analysis
Body Mass Index
Cross-Sectional Studies
Base Pairing

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

Mengel-From, J., Rønne, M. E., Carlsen, A. L., Skogstrand, K., Larsen, L. A., Tan, Q., Christiansen, L., Christensen, K. & Heegaard, N. H. H., 1. jan. 2018, I : Journal of Alzheimer's disease : JAD. 63, 2, s. 591-601

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Monozygotic Twins
MicroRNAs
Immunoassay
Lipoproteins
Longitudinal Studies
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Twin Studies
MicroRNAs
Cognition
Neurobiology
Monozygotic Twins