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2018
169 Downloads (Pure)

Actin depolymerization enhances adipogenic differentiation in human stromal stem cells

Chen, L., Hu, H., Qiu, W., Shi, K. & Kassem, M., 1. maj 2018, I : Stem Cell Research. 29, s. 76-83

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Stromal Cells
Adipocytes
Actins
Phalloidine
Cytochalasin D
131 Downloads (Pure)

Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice

Figeac, F., Andersen, D. C., Nipper Nielsen, C. A., Ditzel, N., Sheikh, S. P., Skjødt, K., Kassem, M., Jensen, C. H. & Abdallah, B. M., maj 2018, I : Bone. 110, s. 312-320

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Estrogens
Osteogenesis
Serum
X-Ray Microtomography
Adipogenesis
83 Downloads (Pure)

Bioactive Nano-fibrous Scaffold for Vascularized Craniofacial Bone Regeneration

Prabha, R. D., Kraft, D. C. E., Harkness, L., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M., mar. 2018, I : Journal of Tissue Engineering and Regenerative Medicine. 12, 3, s. e1537-e1548

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Polyvinyl Alcohol
Bioceramics
Durapatite
Scaffolds
Polyvinyl alcohols
95 Downloads (Pure)

Clinical improvement in a patient with monostotic melorheostosis after treatment with denosumab: a case report

Byberg, S., Abrahamsen, B., Kassem, M., Ralston, S. & Schwarz, P., 27. sep. 2018, I : Journal of Medical Case Reports. 12, 6 s., 278.

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Melorheostosis
zoledronic acid
113 Downloads (Pure)

Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

Schmal, H., Kowal, J. M., Kassem, M., Seidenstuecker, M., Bernstein, A., Böttiger, K., Xiong, T., Südkamp, N. P. & Kubosch, E. J., 1. jan. 2018, I : Stem Cells International. 2018, 12 s., 4142031.

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Chondrocytes
Rabbits
Collagen Type X
Collagen Type II
Collagen Type I

Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals

Bonde Jensen, M., Slots, C., Ditzel, N., Albrektsen, O., Wiatr Borg, S., Thygesen, T., Kassem, M. & Andersen, M. Ø., jun. 2018, I : Bioprinting. 10, e00027.

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Fatty acids
Biomaterials
Powders
Drug products
Fatty Acids
15 Downloads (Pure)
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Gastric Inhibitory Polypeptide
Glucagon-Like Peptide 1
Metabolism
Bone
Incretins
98 Downloads (Pure)

Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration

Chang, C-C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M. & Kjems, J., 7. feb. 2018, I : Molecular Therapy. 26, 2, s. 593-605

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MicroRNAs
Mesenchymal Stromal Cells
Osteoblasts
Osteogenesis
Cell Cycle
137 Downloads (Pure)

High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice

Tencerova, M., Figeac, F., Ditzel, N., Taipaleenmäki, H., Nielsen, T. K. & Kassem, M., jun. 2018, I : Journal of Bone and Mineral Research. 33, 6, s. 1154-1165

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High Fat Diet
Adipose Tissue
Adiposity
Insulin
Adipocytes
109 Downloads (Pure)

Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics

Rumman, M., Majumder, A., Harkness, L., Venugopal, B., Vinay, M. B., Pillai, M. S., Kassem, M. & Dhawan, J., jul. 2018, I : Stem Cell Research. 30, s. 69-80

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Mesenchymal Stromal Cells
Osteogenesis
Autocrine Communication
Paracrine Communication
cdc Genes

International Harmonization and Standardization between Denmark and Germany: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Wendlandt, R., Kowal, J. M., Haakonsson, A. K., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H., Frahm, T., Eckers, A. & 5 flere, Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 31. jul. 2018.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

Leif Mosekilde IN MEMORIAM

Rejnmark, L., Brixen, K., Kassem, M., Hermann, P., Vestergaard, P., Eriksen, E. F., Bollerslev, J., Nielsen, H. K., Charles, P. & Langdahl, B., nov. 2018, I : Journal of Bone and Mineral Research. 33, 11, 1 s.

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93 Downloads (Pure)

Molecular Phenotyping of Telomerized Human Bone Marrow Skeletal Stem Cells Reveals a Genetic Program of Enhanced Proliferation and Maintenance of Differentiation Responses

Twine, N. A., Harkness, L., Adjaye, J., Aldahmash, A., Wilkins, M. R. & Kassem, M., sep. 2018, I : JBMR Plus. 2, 5, s. 257-267

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Mesenchymal Stromal Cells
Maintenance
Cell Aging
Osteoblasts
Cell Cycle
159 Downloads (Pure)

Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress prosurvival signalling pathways

Vishnubalaji, R., Manikandan, M., Fahad, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2. mar. 2018, I : OncoTarget. 9, 17, s. 13551-13564

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Colorectal Neoplasms
Neoplasms
aldehyde dehydrogenase 1
Fluorouracil
Disease-Free Survival
110 Downloads (Pure)

Multiple intracellular signaling pathways orchestrate adipocytic differentiation of human bone marrow stromal stem cells

Ayesh Hafez Ali, D., Abuelreich, S., Alkeraishan, N., Shwish, N. B., Hamam, R., Kassem, M., Alfayez, M., Aldahmash, A. & Alajez, N. M., 30. jan. 2018, I : Bioscience Reports. 38, 1, 10 s., BSR20171252.

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Stem cells
Mesenchymal Stromal Cells
Adipocytes
Bone
Metabolism
53 Downloads (Pure)

NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC

Manikandan, M., Abuelreich, S., Elsafadi, M., Alsalman, H., Almalak, H., Siyal, A., Hashmi, J. A., Aldahmash, A., Kassem, M., Alfayez, M. & Mahmood, A., 1. nov. 2018, I : Differentiation. 104, s. 36-41

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Osteoblasts
Down-Regulation
Cytoplasmic and Nuclear Receptors
Osteogenesis
Small Interfering RNA
86 Downloads (Pure)

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity

Ali, D., Chalisserry, E. P., Manikandan, M., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2018, I : Stem Cells International. 2018, 12 s., 2379546.

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Mesenchymal Stromal Cells
Epigenomics
Adipogenesis
Osteoblasts
Adipocytes
110 Downloads (Pure)

Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway

Abdallah, B., Alzahrani, A. M. & Kassem, M., maj 2018, I : Bone. 110, s. 221-229

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Clusterin
MAP Kinase Signaling System
Osteoblasts
Mesenchymal Stromal Cells
Adipocytes
101 Downloads (Pure)

Stem cell library screen identified ruxolitinib as regulator of osteoblastic differentiation of human skeletal stem cells

AlMuraikhi, N., Ali, D., Alshanwani, A., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, M. & Alajez, N. M., 21. nov. 2018, I : Stem Cell Research & Therapy. 9, 10 s., 319.

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Osteoblasts
Stem cells
Bone
Osteogenesis
Bioinformatics
116 Downloads (Pure)

TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

Elsafadi, M., Manikandan, M., Almalki, S., Mobarak, M., Atteya, M., Iqbal, Z., Hashmi, J. A., Shaheen, S., Alajez, N., Alfayez, M., Kassem, M., Dawud, R. A. & Mahmood, A., 2018, I : Stem Cells International. 2018, 14 s., 6913594.

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Cytochalasin D
Adipogenesis
Gene Expression Profiling
Computational Biology
Transcriptome
2017

Bone and Skeletal Stem Cells are Affected in High Fat Diet Mice

Figeac, F., Tencerova, M., Ditzel, N., Nielsen, T. K. L., Jørgensen, B. & Kassem, M., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D. V., Whyte, M. P. & Frederiksen, A. L., dec. 2017, I : Journal of Bone and Mineral Research. 32, S1, s. S395 1 s., MO0710.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Bone morphology in IKBKG (NEMO) mutation positive women: A case-control study

Frost, M., Tencerova, M., Ejersted, C. A., Svaneby, D., Levin Andersen, T., Kassem, M., McAlister, W. H., Novack, D., Whyte, M. P. & Frederiksen, A. L., 2017.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

157 Downloads (Pure)

CHD1 regulates cell fate determination by activation of differentiation-induced genes

Baumgart, S. J., Najafova, Z., Hossan, T., Xie, W., Nagarajan, S., Kari, V., Ditzel, N., Kassem, M. & Johnsen, S. A., 2017, I : Nucleic Acids Research. 45, 13, s. 7722-7735

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DNA-Binding Proteins
Osteoblasts
Nucleosomes
RNA Polymerase II
Osteogenesis
90 Downloads (Pure)

Chromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cells

Burns, J. S., Harkness, L., Aldahmash, A., Gautier, L. & Kassem, M., 2017, I : Stem Cell Research. 25, s. 6-17

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Mesenchymal Stromal Cells
Diploidy
Comparative Genomic Hybridization
Cell Cycle Checkpoints
Computational Biology
158 Downloads (Pure)

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M., Zaher, W., Alfayez, M., Aldahmash, A. & Alajez, N. M., 7. sep. 2017, I : Cell Death & Disease. 8, 9, 12 s., e3045.

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MicroRNAs
Physiologic Monitoring
Nucleic Acids
Messenger RNA
DNA

CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling

Abdallah, B. M., Figeac, F., Larsen, K. H., Ditzel, N., Keshari, P., Isa, A., Jafari, A., Andersen, T. L., Delaisse, J. M., Goshima, Y., Ohshima, T. & Kassem, M., maj 2017, I : Journal of Bone and Mineral Research. 32, 5, s. 913-926

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Osteoblasts
Osteogenesis
Proteins
Mesenchymal Stromal Cells
Cyclin D1

Cross-border biobanking: The German-Danish Interreg project BONEBANK

Maushagen, R., Gemoll, T., Oberlaender, M., Faccinetti, G., Figge, L., Kock-Schoppenhauer, A-K., Duhm-Harbeck, P., Niessen, L., Unger, A., Waizner, K., Wendlandt, R., Zweig, W., Kowal, J. M., Haakonsson, A., Bober, C., Diercks, K., Nassutt, R., Buescher, R., Reimers, N., Schmal, H. & 12 flere, Duckert, R., Kroeger, I., Stueck, G., Kessel, S., Hecht, M., Frahm, T., Eckers, A., Brilling, J., Barington, T., Kassem, M., Schulz, A-P. & Habermann, J. K., 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review

CUDC-907 Promotes Bone Marrow Adipocytic Differentiation Through Inhibition of Histone Deacetylase and Regulation of Cell Cycle

Ali, D., Alshammari, H., Vishnubalaji, R., Chalisserry, E. P., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2017, I : Stem Cells and Development. 26, 5, s. 353-362

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Histone Deacetylases
Adipocytes
Cell Cycle
Mesenchymal Stromal Cells
Epigenomics

Effects of GIP, GLP-1 and GLP-1RAs on bone cell metabolism

Hansen, M. S., Tencerova, M., Frølich, J. S., Kassem, M. & Frost, M., 2017, I : Basic & Clinical Pharmacology & Toxicology.

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Impact of Calcium and Two Doses of Vitamin D on Bone Metabolism in the Elderly: A Randomized Controlled Trial

Rahme, M., Sharara, S. L., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T., Bassil, D., El Ferkh, K. & El-Hajj Fuleihan, G., 2017, I : Journal of Bone and Mineral Research. 32, 7, s. 1486-1495

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National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Randomized Controlled Trials
Calcium Citrate
Hip
Body Mass Index

Legumain is a Novel Regulator of Bone Formation and Deregulated in Postmenopausal Osteoporosis

Jafari, A., Qanie, D. W. M., Levin Andersen, T., Chen, L., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaissé, J-M., Abdallah, B., Hesselson, D., Solberg, R. & Kassem, M., feb. 2017, I : Journal of Bone and Mineral Research. 31, S1, FR0152.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

230 Downloads (Pure)

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Levin Andersen, T., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., 2017, I : Stem Cell Reports. 8, 2, s. 373-386

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asparaginylendopeptidase
Postmenopausal Osteoporosis
Mesenchymal Stromal Cells
Bone
Osteoblasts
320 Downloads (Pure)

MicroRNA-4739 regulates osteogenic and adipocytic differentiation of immortalized human bone marrow stromal cells via targeting LRP3

Elsafadi, M., Manikandan, M., Alajez, N. M., Hamam, R., Dawud, R. A., Aldahmash, A., Iqbal, Z., Alfayez, M., Kassem, M. & Mahmood, A., 2017, I : Stem Cell Research. 20, s. 94-104

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Lipoprotein Receptors
MicroRNAs
Mesenchymal Stromal Cells
Proteins
Clone Cells
251 Downloads (Pure)

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells

Elsafadi, M., Manikandan, M., Atteya, M., Abu Dawud, R., Almalki, S., Ali Kaimkhani, Z., Aldahmash, A., Alajez, N. M., Alfayez, M., Kassem, M. & Mahmood, A., 2017, I : Scientific Reports. 7, 15 s., 10797.

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Osteoblasts
Mesenchymal Stromal Cells
Adipocytes
Cell Differentiation
Fatty Acids
243 Downloads (Pure)

Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion

Slots, C., Bonde Jensen, M., Ditzel, N., Hedegaard, M. A. B., Borg, S. W., Albrektsen, O., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2017, I : Dental Materials. 33, 2, s. 198–208

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3D printers
Ink
Extrusion
Suspensions
Phosphates

The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo

Bonde Jensen, M., Slots, C., Ditzel, N., Hedegaard, M. A. B., Andersen, T. E., Thygesen, T., Kassem, M. & Andersen, M. Ø., 2. nov. 2017. 1 s.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

113 Downloads (Pure)

The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation

Bermeo, S., Al-Saedi, A., Kassem, M., Vidal, C. & Duque, G., 2017, I : Journal of Cellular Biochemistry. 118, 12, s. 4425–4435

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Nuclear Proteins
Mesenchymal Stromal Cells
Osteogenesis
Adipogenesis
Cell Differentiation
2016

Aging and bone

Gimble, J. M., Floyd, Z. E., Kassem, M. & Nuttall, M. E., 2016, Osteoporosis in Older Persons: Advances in Pathophysiology and Therapeutic Approaches. Duque, G. & Kiel, D. P. (red.). 2. udg. Springer, s. 23-42

Publikation: Bidrag til bog/antologi/rapport/konference-proceedingBidrag til bog/antologiForskningpeer review

273 Downloads (Pure)

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

Vishnubalaji, R., Yue, S., Alfayez, M., Kassem, M., Liu, FF., Aldahmash, A. & Alajez, N. M., 2016, I : Cancer Cell International. 16, 12 s., 77.

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Colonic Neoplasms
Colorectal Neoplasms
Growth
SCID Mice
Computational Biology
90 Downloads (Pure)

CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

Harkness, L., Zaher, W., Ditzel, N., Isa, A. & Kassem, M., 2016, I : Stem Cell Research & Therapy. 7, 1, s. 4-16 13 s.

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Stem cells
Mesenchymal Stromal Cells
Bone
Population
Cells
567 Downloads (Pure)

Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells

Elsafadi, M., Manikandan, M., Atteya, M., Hashmi, J. A., Iqbal, Z., Aldahmash, A., Alfayez, M., Kassem, M. & Mahmood, A., 2016, I : Stem Cells International. 2016, 18 s., 9378081.

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Mesenchymal Stromal Cells
Alkaline Phosphatase
Stromal Cells
Osteoblasts
Homeobox Genes
156 Downloads (Pure)

Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction

Wright, E. J., Hodson, N. W., Sherratt, M. J., Kassem, M., Lewis, A. L., Wallrapp, C., Malik, N. & Holt, C. M., 2016, I : Stem Cells International. 2016, 13 s., 7357096.

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Mesenchymal Stromal Cells
Apoptosis
Atomic Force Microscopy
Conditioned Culture Medium
Polymerase Chain Reaction
127 Downloads (Pure)

Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy

Aggerholm-Pedersen, N., Demouth, C., Safwat, A., Meldgaard, P., Kassem, M. & Sorensen, B. S., 2016, I : Stem Cells International. 2016, 8 s., 9601493.

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Sarcoma
Epidermal Growth Factor Receptor
Cell Survival
Cell Line
Transformed Cell Line
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Osteoblasts
Homeostasis
Luciferases
Osteogenesis
Osteoclasts

Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial

Fuleihan G, EI-H., Baddoura, R., Habib, R. H., Halaby, G., Arabi, A., Rahme, M., Singh, R. J., Kassem, M., Mahfoud, Z., Hoteit, M., Daher, R. T. & Kassir, M-F., 2016, I : The American Journal of Clinical Nutrition. 104, 2, s. 315-323

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Insulin Resistance
Randomized Controlled Trials
Homeostasis
Calcium Citrate
Prediabetic State
113 Downloads (Pure)

Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases

Hotez, P. J. & Kassem, M., 2016, I : P L o S Neglected Tropical Diseases (Online). 10, 12, 4 s., e0005072.

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114 Downloads (Pure)

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells

Ali, D., Hamam, R., Alfayez, M., Kassem, M., Aldahmash, A. & Alajez, N. M., 2016, I : Stem Cells Translational Medicine. 5, 8, s. 1036-1047

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Mesenchymal Stromal Cells
Epigenomics
Stromal Cells
Libraries
Osteoblasts
134 Downloads (Pure)

Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

Morsing, M., Klitgaard, M. C., Jafari, A., Villadsen, R., Kassem, M., Petersen, O. W. & Rønnov-Jessen, L., 2016, I : Breast Cancer Research (Online). 18, s. 108

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Fibroblasts
Mesenchymal Stromal Cells
Morphogenesis
Stromal Cells
Growth

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

Wienken, M., Dickmanns, A., Nemajerova, A., Kramer, D., Najafova, Z., Weiss, M., Karpiuk, O., Kassem, M., zhang, Y., Lozano, G., Johnsen, S. A., Moll, U. M., Zhang, X. & Dobbelstein, M., 2016, I : Molecular Cell. 61, 1, s. 68-83

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Histones
Lysine
Ubiquitin-Protein Ligases
Oncogene Proteins
p53 Genes